Synopses & Reviews
This book aims to integrate research from a broad range of fields on primate-pathogen molecular interactions, primate immune function, and primate-pathogen co-evolution to provide a sound base of knowledge for future investigation of human and non-human primate evolution, immunity, and disease. New research describing how pathogens have affected the evolution of primate genome diversity, cell and immune function, and health will be reviewed and presented. Information compiled in this book will allow the specialist and educated lay-reader to understand and critically evaluate current data on differences in the molecular mechanics of primate immune response, pathogen-mediated primate evolution, and primate health.
Synopsis
The immune systems of human and non-human primates have diverged over time, such that some species differ considerably in their susceptibility, symptoms, and survival of particular infectious diseases. Variation in primate immunity is such that major human pathogens - such as immunodeficiency viruses, herpesviruses and malaria-inducing species ofPlasmodium- elicit striking differences in immune response between closely related species and within primate populations. These differences in immunity are the outcome of complex evolutionary processes that include interactions between the host, its pathogens and symbiont/commensal organisms. The success of some pathogens in establishing persistent infections inhumans and other primateshas been determined not just by the molecular evolution of the pathogen and its interactions with the host, but also by the evolution of primate behavior and ecology, microflora, immune factors and the evolution of other biological systems.
To explore how interactions between primates and their pathogenshave shaped their mutual molecular evolution, Primates, Pathogens and Evolutionbrings together research that explorescomparativeprimate immune function, the emergence of major and neglected primatediseases, primate-microorganism molecular interactions, and related topics. Thisbookwill be of interest to anyone curious as to why infectious diseases manifest differently in humans and their closest relatives. It will be of particular interest to scholars specializing in humanand non-human primate evolution, epidemiology and immunology, and disease ecology.Primates, Pathogens and Evolutionoffers anoverview and discussion of current findings on differences in the molecular mechanics of primate immune response, as well as on pathogen-mediated primate evolution and human and non-human primate health.
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Synopsis
This book details how pathogens affect the evolution of primate genome diversity, cell and immune function, and health--integrating research from fields on primate-pathogen molecular interactions, primate immune function and primate-pathogen co-evolution.
Synopsis
The immune systems of humans and non-human primates have diverged such that these animals show inter- and intra-species variation in susceptibility, symptoms,
Synopsis
The immune systems of
Synopsis
The immune systems of
Table of Contents
Section I Immunity and Primate Evolution Vertebrate Immune system evolution and comparative primate immunity Jessica F. Brinkworth and Mitchell Thorn Genetic variation in the immune system of Old World monkeys: functional and selective effects Dagan A. Loisel and Jenny Tung Toll-like receptor function and evolution in primates Jessica F. Brinkworth and Kirstin N. Sterner Impact of natural selection due to malarial disease on human genetic variation Felicia Gomez, Wen-Ya Ko, Avery Davis, and Sarah A. Tishkoff Parasitic lice help to fill in the gaps of early hominid history Julie M. Allen, Cedric O. Worman, Jessica E. Light, and David L. Reed Section II Emergence and Divergent Disease Manifestation Treponema pallidum infection in Primates: Clinical Manifestations, Epidemiology, and Evolution of a Stealthy Pathogen Kristin Harper and Sascha Knauf Molecular mimicry by -2 herpesviruses to modulate host cell signaling pathways Lai-Yee Wong, Zsolt toth, Kevin F. Brulois, Kyung-Soo Inn, Sun-Hwa Lee, Hye-Ra Lee, and Jae U. Jung Neotropical primates and their susceptibility to Toxoplasma gondii: new insights for an old problem José Luiz Catão-Dias, Sabrina Epiphanio and Maria Cecília Martins Kierulff The Evolution of SIV in primates and the emergence of the pathogen of AIDS Edward JD Greenwood, Fabian Schmidt, and Jonathan L. Heeney Section III Primates, Pathogens and Health Microbial exposures and other early childhood influences on the subsequent function of the immune system Graham A.W. Rook. Make new friends and keep the old? Parasite coinfection and comorbidity in Homo sapiens Melanie Martin, Aaron D. Blackwell, Michael Gurven and Hillard Kaplan Primates, pathogens and evolution: A context for understanding emerging disease Kristin N. Harper, Molly K. Zuckerman, Bethany L. Turner, George Armelagos