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Powell's Staff: New Literature in Translation: December 2022 and January 2023 (0 comment)
It may be a new year, this may be a list of new books, but our love for literature in translation hasn’t changed at all, and we are so pleased to be enthusiastically recommending these recent releases. On this list, you’ll find a Spanish novel where controversy swirls around a Coca-Cola billboard...
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  • Kelsey Ford: From the Stacks: J. M. Ledgard's Submergence (0 comment)
  • Kelsey Ford: Five Book Friday: Year of the Rabbit (1 comment)

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Protein Folding, Misfolding and Aggregation: Classical Themes and Novel Approaches

by Wolynes, Peter
Protein Folding, Misfolding and Aggregation: Classical Themes and Novel Approaches

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  • Synopses & Reviews

ISBN13: 9780854042579
ISBN10: 0854042571



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Synopses & Reviews

Publisher Comments

Protein folding is the process by which newly synthesized proteins fold into the specific three-dimensional structures defining their biologically active states while avoiding aggregation into pathogenic assemblies. It has always been a major focus of research in biochemistry and has often been seen as the unsolved second part of the genetic code. In the last 10 years we have witnessed a quantum leap in the research in this exciting area. Computational methods have improved to the extent of making it possible to simulate the complete folding process of small proteins and the early stages of protein aggregation. Experimental methods have evolved to permit resolution of fast processes of folding reactions and visualisation of single molecules during folding. As a result, the study of protein folding and aggregation has acquired a high level of technical and conceptual sophistication, in which theory, computer simulations and experiments are starting to be combined in a global approach. Protein Folding, Misfolding and Aggregation: Classical Themes and Novel Approaches includes chapters in the areas that have witnessed major developments and are written by top experts in the field. The book is unique in its scope and in its coverage of all the new developments in this area by filling a much needed gap in the current literature. Readers will obtain a unique perspective of the problems faced in the biophysical study of protein conformational behaviour in aqueous solution and how these problems are being solved with a multidisciplinary approach that combines theory, experiment, and computer simulations. RSC The book is essential reading for graduate and postdoctoral students actively involved in protein folding research, other scientists interested in the recent progress of the field, and instructors revamping the protein folding section of their biochemistry and biophysics courses.

Review

"As a whole, the book is strongly focused on current conceptual and theoretical thinking of protein folding.""...it will appeal more to academic scientists involved in fundamental studies." JACS, Vol 130, No 52, 2008

Synopsis

This unique book covers all the modern approaches and the many advances experienced in the field during the last 10 years. There is much emphasis on computational methods and studies of protein aggregation which have really flourished in the last decade. It includes chapters in the areas that have witnessed major developments and written by top experts including: computer simulations of folding, fast folding, single molecule spectroscopy, protein design, aggregation studies (both computational and experimental).

Readers will obtain a unique perspective of the problems faced in the biophysical study of protein conformational behavior in aqueous solution and how these problems are being solved with a multidisciplinary approach that combines theory, experiment and computer simulations.

Synopsis

This unique book covers all the modern approaches and the many advances experienced in the field of protein folding and aggregation during the last 10 years.

Synopsis

The study of protein folding and aggregation has recently acquired a high level of technical and conceptual sophistication, in which theory, computer simulations and experiments are starting to be employed in tight combination. This book includes chapters, in all the areas, that have witnessed the major developments. Written by top experts it is unique in its comprehensive scope and coverage of all new developments in this area. The reader will obtain a perspective of the problems faced in protein folding and aggregation, and how these problems are being solved with a multidisciplinary approach using theory, experiment, and computer simulations.

About the Author

Victor Mu±oz is Associate Professor in Chemistry and Biochemistry at the University of Maryland, USA and Research Professor in Biophysics at the Spanish Research Council (CSIC), Madrid, Spain. He has worked in the area of protein folding and aggregation for the last 16 years and for the last 7 years he has been involved in promoting a change from the classical biochemical to a physical paradigm in experimental protein folding.

Table of Contents

Preface: Classical Themes and Novel Approaches in Protein Folding and Aggregation; Chapter 1: The Helix as the Simplest Protein Folding Model; Helix-Coil Theory, Stability and Design; Chapter 2: Kinetics and Mechanisms of -Helix Formation; Chapter 3: Protein Folding Theory; The Folding Energy Landscape: A Primer; Chapter 4: Hydrogen Exchange Experiments; Detection and Characterization of Folding Intermediates; Chapter 5: Statistical Differential Scanning Calorimetry; Probing Protein Folding-Unfolding Ensembles; Chapter 6: Fast Protein Folding; Chapter 7: Single Molecule Spectroscopy in Protein Folding; From Ensembles to Single Molecules; Chapter 8: Computer Simulations of Protein Folding; Chapter 9: Protein Design; Tailoring Sequence, Structure and Folding Properties; Chapter 10: Protein Misfolding and -Amyloid Formation; Chapter 11: Computational Studies of Protein Aggregation; Molecular Dynamics Simulations and Bioinformatic Analysis of Scenarios for Protein Aggregation


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Product Details

ISBN:
9780854042579
Binding:
Hardcover
Publication date:
06/24/2008
Publisher:
Royal Society of Chemistry
Series info:
RSC Biomolecular Sciences (unnumbered)
Language:
English
Pages:
288
Height:
.86IN
Width:
6.36IN
Thickness:
1.00
LCCN:
2008298649
Series:
Rsc Biomolecular Sciences
Series Number:
13
Number of Units:
1
Copyright Year:
2008
Series Volume:
13
UPC Code:
4294967295
Author:
Andreas Lehmann
Author:
Andrew Doig
Author:
Luis Serrano
Author:
Peter Wolynes
Author:
Stephen Neidle
Author:
Vijay Pande
Author:
D Thirumalai
Author:
Christopher D Snow
Author:
Marius Clore
Author:
Maria T Pastor
Author:
Roderick E. Hubbard
Author:
Royal Society Of Chemistry
Author:
Luis Moroder
Author:
Urmi Doshi
Author:
Bogdan Tarus
Author:
Alexandra Esteras-Chopo
Author:
Eric J Sorin
Author:
Ben Schuler
Author:
Martin Gruebele
Author:
G. Reddy
Author:
Clore Marius
Author:
Seung-gu Kang
Author:
Ruxandra I Dima
Author:
David M. J. Lilley
Author:
Victor Munoz
Author:
Jeff Saven
Author:
Simon Campbell
Author:
Lilley David M J
Author:
John Straub
Author:
Yawen Bai
Author:
Christopher J Lanci
Author:
Beatriz Ibarro-Molero
Author:
Jose M Sanchez-Ruiz
Author:
Young Min Rhee
Author:
Thomas J Petty II
:
Victor Muanoz
Ed:
Victor Mu?oz
Subject:
Proteins -- Denaturation.
Subject:
Proteins
Subject:
Protein folding
Subject:
Denaturation

Ships free on qualified orders.
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$210.95
New Hardcover
Available at a Remote Warehouse. Ships separately from other items. Additional shipping charges may apply. Not available for In Store Pickup. More Info
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QtyStore
20Remote Warehouse
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