Synopses & Reviews
This unique book describes newly discovered proteolytic enzymes and their biological function. In many cases, these enzymes are targets for new drug discovery in order to provide new therapeutic approaches to control human diseases and/or metabolic conditions. The chapters in this book will help other investigators to pursue drug discovery by detailing methods of production and assay of the enzymes. In addition, the latest structural studies that are described in the book will permit rapid advances in drug design. The most important elements of this book are the state-of-the-art, detailed descriptions of the properties of the proteolytic enzymes. The chapters in the book, written by leading experts in the field, collect the best work on the topics with complete bibliographies for each target enzyme. The illustrations are highly informative to aid and facilitate a new design of inhibitors that can be developed as drug candidates. Key chapters include those by Mark Gorrell and Catherine Abbott, both describing dipeptidyl peptidases, which have been implicated in a number of metabolic conditions including diabetes. The chapters are written from two very different perspectives, thus enriching the literature in this area. In addition, the chapter by Sheena McGowan focuses on aminopeptidases from the malaria parasite, Plasmodium falciparum, and the chapter by Ben Dunn deals with the aspartic peptidases from the same organism.
Review
The book thus certainly has the merit to broaden the perspective of readers and will be a good source of new information for those who are already to some degree familiar with research and drug discovery on proteinases and who want to dive deeper into the subject. The Dr. Richard Sedrani
Synopsis
Describes proteolytic enzymes and their biological function to aid drug discovery by detailing methods of production and assay of the enzymes.
Synopsis
This book provides vital information on a class of enzymes that have emerged as key drug targets in a number of human diseases, including HIV/AIDS, Hypertension, Cancer, and Alzheimer's disease. There is a gap in information due to the lack of recent international meetings on this subject and, thus, no recent summaries of current research have emerged. The book contains up-to-date information, especially with the genomics revolution of recent years, and includes new proteomics techniques. The story of this enzyme family also includes the most significant efforts in computer-aided drug discovery and structure-based drug design. With contributions from experts in the field, the book is edited by the previous President of the International Proteolysis Society, whose academic career in the field has spanned 35 years.
About the Author
Ben M Dunn is a Distinguished Professor of Biochemistry and Molecular Biology at the Department of Biochemistry and Molecular Biology, University of Florida, USA. He is also an NIH-funded Investigator and is currently supported by a MERIT award for the NIAID. He was President of the International Proteolysis Society from 2003-2005 and is currently President of the American Peptide Society.
Table of Contents
Dipeptidyl peptidases: Substrates and therapeutic targeting in human health and disease; The Metalloproteases Meprin ? and ?: Pathophysiological roles in Inflammation, Cardiovascular Disease, Cancer, and Fibrosis; Glutamate Carboxypeptidase II as a Therapeutic Target; The Role of Proteolytically Inactive Serine Proteases from Sarcoptes scabiei in Complement Evasion; Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy; Discovery of the Cysteine Protease Cathepsin B as a Drug Target for Alzheimer's Disease; Plasmodium falciparum Neutral Aminopeptidases: Development of novel anti-malarials by understanding enzyme structure; Blood-feeding human hookworm proteases; Structural Mechanisms of Inactivation in Proteolytically Inactive Serine Proteases from Sarcoptes scabiei; The Aspartic Proteinases from the Malaria Parasite: Structure and Function of the Plasmepsins