Reports progress on chemical, enzymatic, phage, and cell-derived libraries. Discusses synergy between structure-based design and combinatorial libraries. Presents applications of combinatorial libraries to drug discovery and new synthetic catalysis. Reports library screening approaches, including the use of NMR. Presents recent advances in solid-phase organic synthesis, liquid-phase organic synthesis, and high-throughput combinatorial organic synthesis. Discusses automation of organic synthesis as well as new methodologies for monitoring solid-phase organic synthesis.
Secondary Structure Templated Libraries: Mimicking Nature,
M. Qabar, J. Urban, C. Sia, M. Klein, and M. KahnConstruct Diversity: A New Paradigm for Combinatorial Chemistry, J.C. Roberts, B.E. Thomas, Y. Shen, A. Melikian-Badalian, P.J. Kowalczyk, and P.V. Pallai
Enhancing the Drug Discovery Process by Integration of High-Throughput Chemistry and Structure-Based Drug Design, T.L. Graybill, D.K. Agrafiotis, R. Bone, C.R. Illig, E.P. Jaeger, K.T. Locke, T. Lu, J.M. Salvino, R.M. Soll, J.C. Spulino, N. Subasinghe, B.E. Tomczuk, and F.R. Salemme
Phosphorus as a Scaffold: Combinatorial Libraries of Non-nucleotide Phosphoramidates, A.F. Cook and R. Fathi
Convergent Solid-Phase Synthesis of Phosphoramidate Combinatorial Libraries, N. H�bert
Solid-Phase Synthesis, Characterization, and Screening of a 43,000-Compound Tetrahydroisoquinoline Combinatorial Library, M.C. Griffith, C.T. Dooley, R.A. Houghten, and J.S. Kiely
Solid-Phase and Combinatorial Synthesis of Heterocyclic Scaffolds: Dihydropyridines, Pyridines, and Pyrido [2,3-d]pyrimidines, D.V. Patel, M. F. Gordeev, B.P. England, and E.M. Gordon
Polymer-Supported Chemistry: Synthesis of Small-Ring Heterocycles, A.M.M. Mjalli and B.E. Toyonaga
A Solution-Phase Strategy for the Parallel Synthesis of Chemical Libraries Containing Small Organic Molecules: A General Dipeptide Mimetic and a Flexible General Template, C.M. Tarby, S. Cheng, and D.L. Boger
Structurally Homogeneous and Heterogeneous Libraries: Scaffold-Based Libraries and Libraries Built Using Bifunctional Building Blocks, V. Krch%n�k, A. S. Weichsel, D. Cabel, and M. Lebl
Liquid-Phase Combinatorial Synthesis, D.J. Gravert and K.D. Janda
Libraries of Transition-Metal Catalysts: High-Throughput Screening of Catalysts for Synthetic Organic Methodology, K. Burgess, D. Moye-Sherman, and A.M. Porte
Mixtures of Molecules Versus Mixtures of Pure Compounds on Polymeric Beads, M. Stankova, P. Strop, C. Chen, and M. Lebl
Generation of Solution-Phase Libraries of Organic Molecules by Combinatorial Biocatalysis, Y.L. Khmelnitsky, P.C. Michels, J.S. Dordick, and D.S. Clark
Living Libraries Using Gene Transfer: A Renaissance for Natural Products, K.A. Thompson
Phage Expression of a De Novo Designed Coiled Coil Stem Loop Miniprotein Scaffold for Constrained Peptide Library Display, R.M. Miceli, D.G. Myszka, C. E. Peishoff, and I.M. Chaiken
Automation of High-Throughput Synthesis: Automated Laboratory Workstations Designed to Perform and Support Combinatorial Chemistry, J.R. Harness
Boosting the Productivity of Medicinal Chemistry Through Automation Tools: Novel Technological Developments Enable a Wide Range of Automated Synthetic Procedures, O. Gooding, P.D. Hoeprich, Jr., J.W. Labadie, J.A. Porco, Jr., P. van Eikeren, and P. Wright
A Modular System for Combinatorial and Automated Synthesis, S.H. DeWitt, B.R. Bear, J.S. Brussolo, M.J. Duffield, E.M. Hogan, C.E. Kibbey, A.A. MacDonald, D.G. Nickell, R.L. Rhoton, and G.A. Robertson
LiBrain: Software for Automated Design of Exploratory and Targeted Combinatorial Libraries, A. Polinsky, R.D. Feinstein, S. Shi, and A. Kuki
Automation Issues at the Interface Between Combinatorial Chemistry and High-Throughput Screening, B.E. Bauer
Tools for Combinatorial Chemistry, K. Russell, D.C. Cole, F.M. McLaren, and D.E. Pivonka
Magic-Angle Spinning NMR Spectroscopy of Polystyrene-Bound Organic Molecules: Monitoring a Three-Step Solid-Phase Synthesis Involving a Heck Reaction, C. Dhalluin, I. Pop, B. D�prez, P. Melnyk , A. Tartar, and G. Lippens
A High-Throughput Functional Assay for G-Protein-Coupled Receptors: Method for Screening Combinatorial Libraries, C. J. Molineaux, W. Goodwin, L. Chai, X. Zhang, and D. I. Israel
Use of Combinatorial Libraries in the Discovery and Development of Novel Anti-infectives, M. A. Wuonola and D.G. Powers
Application of Polymer-Supported Chemistry to the Discovery and Optimization of Lead Drug Candidates, A.L. Harris and B.E. Toyonaga
Using Pharmacophore Diversity To Select Molecules To Test from Commercial Catalogues, K. Davies