Synopses & Reviews
Considering the current interest in cellular regulation and intracellular signalling systems, it is surprising that the contribution of ADP-ribosylation reactions to the modulation of a variety of specific cell processes, in parallel with other post-translational modifications such as phosphorylation, has not been generally recognized. While it is not feasible to cover all aspects of ADP-ribosylation, the thirty-one articles contained in this volume provide a valuable overview of recent progress in the field within the context of cell control mechanisms. For the convenience of the reader, the various topics have been grouped into several sections: (a) poly(ADP-ribosyl)ation; (b) mono-ADP-ribosylation; (c) toxin mono-ADP-ribosylation; (d) inhibitors and activators; (e) protein modification with ADP-ribose and its analogues; and (f) non-modification forms of ADP-ribose. The contents of the individual chapters reflect the ideas of the contributors, many of whom have spent their careers attempting to resolve the biological functions of ADP-ribosylation. We hope that this publication will serve as a useful reference for those investigators that are new to the area as well as those who are actively studying ADP-ribosylation.
Table of Contents
Preface.
I: Historical Perspective.
II: Poly(ADP-ribosyl)ation.
A. Structure and Enzymology of Poly(ADP-ribose) Polymerase.
B. Polymer Regulation.
C. Cellular Functions.
D. Poly(ADP-ribose) Polymerase Gene Regulation.
III: Mono(ADP-ribosylation).
A. ADP-ribosylation Cycle.
B. Cellular Mono-ADP-ribosylation.
IV: Toxin Mono-ADP-Ribosylation.
V: Inhibitors and Activators of ADP-Ribosylation.
VI: Derivitization of Proteins with ADP-ribose, NAD and their Analogues.
VII: Cyclic ADP-ribose, NAD Hydrolysis and ADP-ribose Synthesis.