Synopses & Reviews
In this greatly enlarged and thoroughly updated edition of his much praised Cardiac Markers, Alan Wu and his contributors focus on the use of markers in the practice of cardiology and-for the first time-on the use of natriuretic peptides for congestive heart failure. Here, leading international authorities in clinical chemistry and laboratory medicine, cardiology, emergency medicine, and the in vitro diagnostics industry describe the state-of-the-art uses of cardiac markers when treating coronary artery disease, and discuss in detail how they may be optimally used in a clinical setting. Comprehensive and cutting-edge, Cardiac Markers, Second Edition offers physicians a complete guide to the use of cardiac markers in clinical practice and clinical laboratorians a close-up view of the new markers now becoming standard.
Review
"addresses the need in a variety of disciplines for an understanding of the evolving role of cardiac markers, particularly in relation to the diagnosis and treatment of acute coronary syndromes. The book provides a concise and informative summary of a rapidly developing field and will be a useful addition to the book-shelves of clinical pathologists, emergency physicians, and cardiologists." -New England Journal of Medicine "...a valuable addition to the compendium of laboratory medicine literature on diagnostic tests and their appropriate clinical application...highly recommended for any individual interested in the state-of-the-art of appropriate laboratory assessment of the acute coronary syndrome patient." -Doody's Health Sciences Book Review Journal "This comprehensive book not only offers physicians a complete guide to the use of cardiac markers in clinical practice, but also provides clinical laboratories with detailed information on the new markers which are now becoming standard." - Clinical Laboratory International "...highly recommended as a reference resource for cardiologists, internists, emergency medicine physicians, and laboratory medicine physicians who have specific questions regarding the many clinically relevant cardiac markers...will save the physician considerable time and effort in answering a specific question that he or she may have within this rapidly evolving field." - Texas Heart Institute Journal From reviews of the first edition... "...provides a concise and informative summary of a rapidly developing field and will be a useful addition to the bookshelves of clinical pathologists, emergency physicians, and cardiologists." -New England Journal of Medicine "...a valuable addition to the compendium of laboratory medicine literature on diagnostic tests and their appropriate clinical application...highly recommended for any individual interested in the state-of-the-art of appropriate laboratory assessment of the acute coronary syndrome patient." -Doody's Health Sciences Book Review Journal
Table of Contents
Part I. Cardiac Markers in Clinical Practice
Early Detection of Myocardial Necrosis in the Emergency Setting and Utility of Serum Biomarkers in Chest Pain Unit Protocols
Andra L. Blomkalns and W. Brian Gibler
Management of Acute Coronary Syndromes
Constantine N. Aroney and James A. de Lemos
Evolution of Cardiac Markers in Clinical Trials
Alexander S. Ro and Christopher R. deFilippi
Assessing Reperfusion and Prognostic Infarct Sizing with Biochemical Markers: Practice and Promise
Robert H. Christenson and Hassan M. E. Azzazy
The Use of Cardiac Biomarkers to Detect Myocardial Damage Induced by Chemotherapeutic Agents
Eugene H. Herman, Steven E. Lipshultz, and Victor J. Ferrans
The Use of Biomarkers to Provide Diagnostic and Prognostic Information Following Cardiac Surgery
Jesse E. Adams, III
Part II. Clinical Use for Cardiac Troponins
Cardiac Troponins: Exploiting the Diagnostic Potential of Disease-Induced Protein Modifications
Ralf Labugger, D. Kent Arrell, and Jennifer E. Van Eyk
Cardiac Troponin Testing in Renal Failure and Skeletal Muscle Disease Patients
Fred S. Apple
Cardiac-Specific Troponins Beyond Ischemic Heart Disease
David Morrow
Part III. Analytical Issues for Cardiac Markers
Antibody Selection Strategies in Cardiac Troponin Assays
Alexei Katrukha
Interferences in Immunoassays for Cardiac Troponin
Kiang-Teck J. Yeo and Daniel M. Hoefner
Cardiac Marker Measurement by Point-of-Care Testing
Paul O. Collinson
Standardization of Cardiac Markers
Mauro Panteghini
Analytical Issues and the Evolution of Cutoff Concentrations for Cardiac Markers
Alan H. B. Wu
Part IV. Early Cardiac Markers of Myocardial Ischemia and Risk Stratification
Rationale for the Early Clinical Application of Markers of Ischemia in Patients with Suspected Acute Coronary Syndromes
Robert L. Jesse
Ischemia-Modified Albumin, Free Fatty Acids, Whole Blood Choline, B-Type Natriuretic Peptide, Glycogen Phosphorylase BB, and Cardiac Troponin
Alan H. B. Wu, Peter Crosby, Gary Fagan, Oliver Danne, Ulrich Frei, Martin Möckel, and Joseph Keffer
C-Reactive Protein for Primary Risk Assessment
Gavin J. Blake and Paul M. Ridker
Prognostic Role of Plasma High-Sensitivity C-Reactive Protein Levels in Acute Coronary Syndromes
Luigi M. Biasucci, Antonio Abbate, and Giovanna Liuzzo
Preanalytic and Analytic Sources of Variations in C-Reactive Protein Measurement
Thomas B. Ledue and Nader Rifai
Fatty Acid Binding Protein as an Early Plasma Marker of Myocardial Ischemia and Risk Stratification
Jan F. C. Glatz, Roy F. M. van der Putten, and Wim T. Hermens
Oxidized Low-Density Lipoprotein and Malondialdehyde-Modified Low-Density Lipoprotein in Patients with Coronary Artery Disease
Paul Holvoet
Part V. Cardiac Markers of Congestive Heart Failure
Pathophysiology of Heart Failure
Johannes Mair
B-Type Natriuretic Peptide: Biochemistry and Measurement
Jeffrey R. Dahlen
B-Type Natriuretic Peptide in the Diagnoses and Management of Congestive Heart Failure
Ramin Tabbibizar and Alan Maisel
Monitoring Efficacy of Treatment with Brain Natriuretic Peptide
Emil D. Missov and Leslie W. Miller
N-Terminal Pro-B-Type Natriuretic Peptide
Torbjørn Omland and Christian Hall
Part VI. Role of Infectious Diseases and Genetics in Heart Disease
Infectious Diseases in the Etiology of Atherosclerosis and Acute Coronary Syndromes: Focus on Chlamydia pneumoniae
Martin Möckel
Polymorphisms Related to Acute Coronary Syndromes and Heart Failure: Potential Targets for Pharmacogenomics
Alan H. B. Wu
Index