Synopses & Reviews
This book discusses drug-induced hepatotoxicity in its entirety from details of molecular mechanisms to clinical case presentations. Special features of drug-induced hepatotoxicity during pregnancy, in pediatric practice, and in the elderly are described. It is complemented by a complete index of all drugs and a comprehensive table of contents allows ready access to all of the knowledge concerning each drug and each class of drugs. Special features include chapters on Reye's syndrome, in vitro models of liver toxicity, hepatic encephalopathy, and alcohol-induced liver injury. The reader will benefit from the scholarly approach to the subject, from the detailed discussions of mechanims and from the attention to details of hepatic responses to each drug.
Synopsis
The advances in science and medicine we are now experiencing are unprec- edented and exciting. Life expectancy is prolonged, and quality of life is much improved. We learn of fabulous new discoveries made at the bench or the bedside every week. Many diseases have been totally eliminated, others can be significantly improved by new therapeutic formulations. Much of the success can be attributed to a better understanding of disease processes and the specific targeting of new and more effective medications. As is the case in many areas of successful human endeavour, there can be a downside. In the case of drugs and chemicals it is their adverse effects which are of concern. Of course, every effort is made to devise medications that are safe, and the need to elucidate and understand mechanisms are crucial, yet adverse effects remain a problem. They can be unpredictable and diverse. Drugs have been shown to induce virtually the whole gamut of human liver pathology from acute fulminant hepatitis to chronic active hepatitis to cirrho- sis and even malignancy. Hence the possibility of adverse drug effects must be considered in the differential diagnosis of many patients with liver disease. This is well recognized and is very important; indeed, removal of the offending agent can often lead to reversal of the adverse effect. This is an area of hepatology where we can really make a difference.