Synopses & Reviews
The biochemistry text that every medical student must own--now in full color! Comprehensive, concise, and up-to-date, Harper's is unrivaled in its ability to clarify the link between biochemistry and the molecular basis of health and disease.
The Twenty-Eighth Edition has undergone sweeping changes -- including a conversion to full-color artwork and the substantial revision and updating of every chapter -- all to reflect the latest advances in knowledge and technology and to make the text as up-to-date and clinically relevant as possible. Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, Harper's Illustrated Biochemistry offers an organization and clarity not found in any other text on the subject.
Striking just the right balance between detail and brevity, Harpers Illustrated Biochemistry is essential for USMLE review and is the single best reference for learning the clinical relevance of a biochemistry topic.
NEW to this edition:
- Full-color presentation, including 600+ illustrations
- Every chapter opens with a Summary of the Biomedical Importance and concludes with a Summary reviewing the topics covered
- Two all-new chapters: "Free Radicals and Antioxidant Nutrients" and "Biochemical Case Histories" which offers an extensive presentation of 16 clinical conditions
- A new appendix containing basic clinical laboratory results and an updated one with a list of important websites and online journals
- NEW or updated coverage of important topics including the Human Genome Project and computer-aided drug delivery
Synopsis
The best biochemistry book for medical students is now in full-color
Applauded by medical students for its detail and accessibility, "Harper's Illustrated Biochemistry" offers unmatched coverage of the principles of biochemistry and molecular biology as they relate to medicine. The Twenty-Eighth edition features a conversion to full-color art, the addition of case studies to every chapter, a larger trim size, and new pedagogy.
About the Author
Robert K. Murray, MD, PhD, Professor (Emeritus) of Biochemistry, University of Toronto
David A. Bender, PhD, Sub-Dean, University College Medical School, Senior Lecturer in Biochemistry, Department of Structural and Molecular Biology and Division of Medical Education, University College London
Kathleen M. Botham, PhD, DSc, Professor of Biochemistry, Royal Veterinary College, University of London
Peter J. Kennelly, PhD, Professor and Head, Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia
Victor W. Rodwell, PhD, Emeritus Professor of Biochemistry, Purdue University, West Lafayette, Indiana
P. Anthony Weil, PhD, Professor of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee
Co-Authors:
Daryl K. Granner, MD, Emeritus Professor of Molecular Physiology and Biophysics and Medicine, Vanderbilt University, Nashville, Tennessee
Peter L. Gross MD, MSc, FRCP(C), Associate Professor, Department of Medicine, McMaster University
Frederick W. Keeley, PhD, Associate Director and Senior Scientist, Research Institute, Hospital for Sick Children, Toronto, and Professor, Department of Biochemistry, University of Toronto
Peter A. Mayes, PhD, DSc, Emeritus Professor of Veterinary Biochemistry, Royal Veterinary College, University of London
Margaret L. Rand, PhD, Associate Senior Scientist, Hospital for Sick Children, Toronto, and Professor, Departments of Laboratory Medicine and Pathobiology and Department of Biochemistry, University of Toronto
Table of Contents
1. Biochemistry and Medicine 2. Water and PH 3. Amino Acids and Peptides 4. Proteins: Determination of Primary Structure 5. Proteins: Higher Orders of Structure 6. Proteins: Myoglobin and Hemoglobin 7. Enzymes: Mechanisms of Action 8. Enzymes: Kinetics 9. Enzymes: Regulation of Activities 10. Bioenergetics: The Role of ATP 11. Biologic Oxidation 12. The Respiratory Chain and Oxidative Phosphorylation 13. Carbohydrates of Physiologic Significance 14. lipids of Physiologic Significance 15. Overview of Metabolism 16. The Citric acid Cycle: The Catabolism of Acetyl-CoA 17. Glycolysis and Oxidation of Pyruvate 18. Metabolism of Glycogen 19. Gluconeogenesis and Control of the Blood Glucose 20. The Pentose Phosphate Pathway and other Pathways of Hexose Metabolism 21. Biosynthesis of Fatty Acids 22. Oxidation of Fatty Acids: Ketogenesis 23. Metabolism of Unsaturated Fatty Acids and Eicosanoids 24. Metabolism of Acyglycerols and Sphingolipids 25. Lipid Transport And Storage 26. Cholesterol Synthesis, Transport and Excretion 27. Integration of Metabolism- the Provision of Metabolic Fuels 28. Biosynthesis of Nutritionally Nonessential Amino Acids 29. Catabolism of Proteins and of Amino Acid Nitrogen 30. Catabolism of the Carbon Skeletons of Amino Acids 31. Conversion of Amino Acids 32. Porphyrins and Bile Pigments 33. Nucleotides 34. Metabolism of Purine and Pyrimidine Nucleotides 35. Nucleic Acid Structure and Function 36. DNA Organization, Replication and Repair 37. RNA Synthesis, Processing and Modifications 38. Protein Synthesis and Genetic Code 39. Regulation of Gene Expression 40. Molecular Genetics, Recombinant DNE and Genomic Technology 41. Membranes: Structure and Function 42. The Diversity of Endocrine System 43. Hormone Action and Signal Transduction 44. Nutrition, Digestion and Absorption 45. Vitamins and Minerals 46. Intracellular Traffic and Sorting of Proteins 47. Glycoprotein 48. The Extracellular Matrix 49. Muscle and the Cytoskeleton 50. Plasma Proteins and Immunoglobulins 51. Homeostasis and Thrombosis 52. The Red and White Blood Cells 53. Metabolism of Xenobiotics 54. The Human Genome Project