Synopses & Reviews
This volume focuses on molecular genetic/drug manipulation affecting the biology of hematopoiesis, leukemia, and other related cancers as well as on hemoglobinopathy, aplastic anemia, pediatric oncology, growth factors in transplantation, hematologic malignancies, solid tumor chemotherapy and drug resistance, gene expression and gene transfer and on viruses and hematopoiesis. Some of the topics covered include: new information on BMT for autoimmune disease and organ transplants, new findings on gene therapy/transfer into HSC, new studies on gene transfer into primates, new information on gene transfer, scientific and clinical results of iron overload and hematopoiesis, iron and erythropoiesis and search for candidate genes, molecular diagnosis and chemotherapy, use of cord blood stem cells for transplantation, and new information on transcriptional factors regulating hematopoiesis.
Synopsis
This volume of Molecular Biology of Hematopoiesis is dedicated to many inter- national scientists and clinicians for their contribution to the field of Hematology/ Oncology presented at the 11th International Symposium on Molecular Biology of Hematopoiesis, which was held in Bormio, Italy, June 25-29, 1998. The continuous support of the Presidents of the meeting, Professor F. Takaku, President of Jichi University, and E. D. Thomas, Nobel Laureate, was greatly acknowledged, especially Professor Takaku, for his vision and support for development of gene therapy in Japan. New information on BMT for autoimmune disease and organ transplantation was presented at the symposium and is published in this volume. Several new findings on gene therapy/transfer into HSC were presented by E. F. Vanin and A. Nienhuis, K. Humphries, 1. A. Nolta, H. E. Heslop, and M. K. Brenner. Professors S. Asano and K. Tani presented new studies on gene transfer into primates. Among the highlights were the new papers on gene transfer presented by G. Wage maker, N. G. Abraham, and M. Onoderea from R. M. BJaese's group. The use of BMT for organ transplant and autoim- mune disease was updated and a representative paper is presented in this volume.
Table of Contents
Part I: Hematopoietic Stem Cell Development. 1. The Development of Hematopoietic Cell Transplantation and its Application to Organ Transplantation and Autoimmune Diseases; E.D. Thomas. 2. Hemopoietic Stem Cells - Normal and Abnormal; S. Ikehara. 3. Immunity and Tolerance are Related, and Governed by Antigen Migration and Localization; T.E. Starzl, et al. 4. Genetic Approaches to the Investigation of the Mechanisms of Hematopoietic Progenitor Cell Mobilization into the Blood; A.W. Roberts, et al. 5. Role of Hematopoietic Growth Factors on the Ex-Vivo Expansion of Primitive Cord Blood Stem Cells; M. Aglietta, et al. 6. Thymus-Independent T Cell Differentiation In Vitro; M. Sanchez, et al. 7. Immunogenetics Problems in Cord Blood Transplantation; F. Poli, et al. Part II: Update on Solid Tumor and Bone Marrow Transplantation. 8. High-Dose Chemotherapy for Breast Cancer in Europe: From Fashion to Randomization; G. Rosti, et al. 9. Differential Enhancement of Graft-versus-Host (GVH) and Graft-versus-Leukemia (GVL) Reactions by Interleukin-12 (IL-12); M. Schmitt, et al. 10. De Novo and Secondary AML Cells Differ in Their Kinetic Response to HGF Priming; M.A. Smith, et al. 11. Clinical Factors Contributing to the Pace of Engraftment after Allogeneic and Autologous Stem Cell Transplantation: Multivariate Analysis; G.J. Elfenbein. 12. Clinical Relevance of Bone Marrow Histologic Examination in HIV-Infected Patients; S. Cantoni, et al. 13. Molecular Biology of Childhood Solid Tumors; Promises Maintained and Promises Postponed; C. Dominici, P. Kogner. 14. Molecular Genetics of Wilms Tumor; K. Pritchard-Jones. 15. Genetic Heterogeneity in Ewing Tumors and Neuroblastomas; P.F. Ambros, et al. 16. Mechanisms of Retinoid Inhibition of Cell Proliferation in Neuroblastoma; T. Matsuo, C.J. Thiele. 17. Combination of Carboplatin and Etoposide in the Management of Intraocular Retinoblastoma; M.A. Castello, et al. 18. Hyper-IL-6 (H-IL-6), a Fusion Protein of Soluble IL-6 Receptor (sIL-6R) and Interleukin-6 (IL-6), Acts Synergistic with Thrombopoietin (TPO) and Stem Cell Factor (SCF) in Expanding Megakaryocyte Progenitors from Human CD34++/CD90+ Cell; J. Birkmann, et al. 19. Towards Vaccination with Defined Tumor Antigens? P. van de Bruggen, et al. Part III: Myloproliferative Disorders: Basic and Clinical Update. 20. Classification of Malignant Lymphomas: State of the Art; S.A. Pileri, E. Sabattini. The Pathologic Spectrum of AIDS-Related Non-Hodgkin's Lymphomas; U. Carbone, et al. 22. Genesis and Progression of Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma; M-Q. Du, P.G. Isaacson. 23. De Novo and Secondary AML Cells Differ in Their Kinetic Response to HGF Priming; M.A. Smith, et al. 24. Molecular Diagnosis of Philadelphia-Positive Leukemias; C. Haškovec, J. Polák. 25. Molecular Monitoring of Non-Hodgkin's Lymphomas; A. Slavickova, et al. Part IV: Regulation of Hematopoiesis. 26. Differential Expression of IL-3 and GM-CSF Receptor Common Signal Transducing Subunit (&bgr;C) During Normal Hematopoietic Differentiation; U. Testa, et al. 27. Expression of Distal Gata 1 Transcripts in Erythroid Cells; A.M. Vannucchi, et al. 28. Expressions of FAS (CD95) and FAS Ligand in HIV Infected Individuals; N. Hosaka, et al. 29. Cytokines, Thrombopoietin and Selectins in Immune Thrombocytopenic Purpura; I.C. Haznedaroglu, et al. 30. Molecular Biology of Hypoxia-Inducible Factor-1; R.H. Wenger, M. Gassman. 31. Identification and Characterization of Constitutively Active STAT5; T. Nosaka, et al. Part V: Novel Approaches to Gene Transfer and Gene Therapy. 32. Gene Transfer to the Nervous System Using High-Titer Retroviral Vector; K. Nanmoku, et al. 33. Hematological Aspects of Common Marmoset Monkey Transplanted with Autologous MIDR1 Gene Transduced Peripheral Blood Stem Cells; K. Tani, et al. 34. Differential Expression of IL-3 and GM-CSF Receptor Common Signal Transducing Subunit (Beta C) During Normal Hematopoietic Differentiation; U. Testa, et al. Part VI: Iron Metabolism and Hematopoiesis. 35. The Basis of a Rational Nutritional Approach to Patients with Cancer; F.R. Fanelli, et al. 36. Prostaglandin's Suppressing Effect on Bone Marrow Erythropoiesis in Rats; V. Kalaidjieva. 37. Pattern of PU.1 Binding to M-CSF Receptor Promotor During Monocyte to Macrophage Maturation; N.M. Sposi, et al. 38. Lymphocyte Populations in Hereditary Spherocytosis Pre and Post Splenectomy and under Oxidative Stress; E. Granjo, et al. 39. The Hereditary Hemochromatosis Gene and Iron Homeostatis; J.N. Feder, et al. 40. An Increase in the Levels of Retroviral-Mediated Transduction of Engrafting Human Hematopoietic Progenitors can be Obtained by Manipulation of the Hematopoietic Cell Cycle; M.A. Dao, J.A. Nolta. 41. Juvenile Hemochromatosis: Search for Candidate Genes; C. Camaschella, et al. 42. New Insights on Congenital Dyserithropoietic Anemia Type II; A. Iolascon, et al. 43. Effects of Retrovirus and Adenovirus Mediated Interferon Gene Transfer on Hematopoietic Progenitor Cell Growth; N.G. Abraham, et al. 44. Transcriptional Regulation of the Ferritin H-Chain and Transferrin Receptor in Hematopoietic Cells; G. Marziali, et al.