Synopses & Reviews
For all volumes: the volumes of Organic Reactions are collections of chapters each devoted to a single reaction or a definitive phase of a reaction, of wide applicability. The authors have had experience with the processes surveyed. The subjects are presented from the preparative viewpoint and particular attention is given to limitations, interfering influences, effects of structure and the selection of experimental techniques. Each chapter includes several detailed procedures illustrating the significant modifications of the method. Each chapter contains tablets that include all the examples of the reaction under consideration that the author has been able to find.
Review
?Overall this book is a very useful addition to an organic chemist?s library and is written for both the student and the expert in the field. It will be especially helpful to those who wish to use the allylboration reaction in a synthesis as well asto those interested in furthering the field of allylboration chemistry.? (
Journal of the American Chemical Society, October 2009)
?This well written volume of Organic Reactions makes an excellent library resource that comprehensively covers the chemistry of allylboronation of carbonyl compounds. It should make an excellent reference text for graduate students and researchers who are new to this reaction or for researchers who need inspiration for the use of this chemistry.? ( Journal of Medicinal Chemistry , August 2009)
Synopsis
Allylic boron compounds have gained a prominent position as a truly practical class of synthetic reagents in the past twenty-five years. Their main application as a method for the stereoselective synthesis of homoallylic alcohols by allyl-transfer to carbonyl compounds is essentially unmatched. In this process, a new carbon-carbon bond is formed, and up to two new stereogenic centers are created in a predictably controlled manner. Highly effective and general enantioselective variants are available, with countless applications in the total syntheses of polyacetate and polypropionate natural products. Furthermore, the residual allylic unit can be manipulated through a number of different transformations such as oxidative cleavage, olefin metathesis, hydrometalations, and many others. The discovery of Lewis and Br nsted acid catalyzed manifolds recently, has opened new doors for further development of this important reaction. This book provides an up-to-date, comprehensive survey of the literature of this rich chemistry as it pertains to organic synthesis.
Consistent with the goal of Organic Reactions, the content and presentation emphasize the preparative aspects of the reactions, giving considerable attention to the scope and limitations of the individual transformations along with detailed experimental procedures. A tabular survey of all examples of carbonyl allylboration used in organic synthesis is presented in nine tables organized by type of allylic boron reagent with listings within each table according to increasing carbon number of the carbonyl substrates.
The literature is covered through December 2010, including a new listing of nearly 200 literature citations that supplement the original coverage of 834 references used in the earlier hard cover version of the chapter. Allylboration of Carbonyl Compounds is intended to be a useful, easily read reference book for all practitioners of synthetic organic chemistry working in academic and industrial laboratories.
About the Author
Dr. Karlalbrecht is a management consultant, executive advisor, futurist, researcher, speaker, and prolific author. In his thirty-year career he has worked with many kinds of business, government, and nonprofit organizations in a wide range of industries world-wide. He has consulted with senior executives and lectured to conferences on all inhabited continents. He is the author of more than twenty books on various aspects of individual and business performance, including
Social Intelligence: The New Science of Success; Brain Power: Learn to Improve Your Thinking Skills; The Northbound Train: Finding the Purpose, Setting the Direction, Shaping the Destiny of Your Organization; The Power of Minds at Work: Organizational Intelligence in Action; and co-author of the best-selling
Service America!: Doing Business in the New Economy, widely credited with launching the “customer revolution” in the U.S. and abroad, which has sold over a halfmillion copies in seven languages.
He devotes much of his effort to finding and developing promising new concepts for both organizational and individual effectiveness. His research and development activities have spanned a wide range of issues, from individual creativity all the way to corporate strategic vision. He is widely regarded as a key thought leader in the field of emerging strategic business issues. He can be contacted at www.KarlAlbrecht.com.
Table of Contents
CHAPTER PAGE.
1. ALLYLBORATION OF CARBONYL COMPOUNDS (Hugo Lachance and Dennis G. Hall).
CUMULATIVE CHAPTER TITLES BY VOLUME.
AUTHOR INDEX, VOLUMES 1–73.
CHAPTER AND TOPIC INDEX, VOLUMES 1–73.