This volume covers all aspects of oxygen delivery to tissue, including blood flow and its regulation, as well as oxygen metabolism. Special emphasis is placed on methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This is a multidisciplinary volume designed to bring together experts and students from a range of research fields.
Tumor Biology and Physiology. 1. The Role of Tumor Oxygenation in Vascular and Clinical Response to Angiogenesis Inhibition;
M.S. Gee, W.M.F Lee. 2. Comparison of Fluctuations of Oxygen Tension in FSA, 9L and R3230AC Tumors in Rats;
L.I. Cárdenas-Navia, et al. 3. Effect of Carbogen-Breathing on Redox Status of the RIF-1 Tumor;
G. Illangovan, et al. 4. Evaluation of Microregional Variations in Tumor Hypoxia Following the Administration of Endostatin;
B.M. Fenton, et al. 5. Effect of Hydralazine on Blood Flow, Oxygenation and Interstitial Fluid Pressure in Subcuataneous Tumors;
T. Jarm, et al. 6. Oxygenation of Cervix Cancers: Impact of Clinical and Pathological Parameters;
M. Höckel, P. Vaupel. 7. Quantitative Spatial Analysis of Hypoxia and Vascular Perfusion in Tumor Sections;
T.M. Busch, et al. 8. Tumor Oxygenation and its Relevance to Tumor Physiology and Treatment;
P. Vaupel, M. Höckel. 9. Mechanisms Underlying Hypoxia Developments in Tumors;
M.W. Dewhirst. 10. Lack of Association Between Tumor Hypoxia, GLUT-1 Expression and Glucose Uptake in Experimental Sarcomas;
O. Thews, et al. 11. The Impact of Tissue Microenvironment on Treatment Simulation;
A. Dasu, J. Denekamp. 12. Evidence for and Against Hypoxia as the Primary Cause of Tumor Aggressiveness;
P. Okunieff, et al. 13. Characterization of Human Gc Protein-Derived Macrophage Activation Factor (GcMAF) and its Functional Role in Macrophage Tumoricidal Activity;
S.B. Mohamad, et al. Blood Physiology and Blood Substitutes. 14. Effect of Hemoglobin Solutions as Hemodiluents on Capillary Oxygen Tension;
R.N. Pittman, et al. 15. Different Efficacy
In Vitro of Hemoglobin Based Oxygen Carriers and Red Cells;
E. Bucci, et al. 16. A Novel Blood Transfusant Candidate: Intact Human Erythrocytes Containing Hemoglobin Exclusively Nitrosylated in the &agr;-Subunits;
A. Tsuneshige, T. Yonetani. 17. The Contribution of Hemoglobin to Oxygen Transport in the Microcrustacean
Daphnia Magna;
R. Pirow. 18. Modifications of Red Blood Cell Shape and Glycoproteins Membrane Content in Septic Patients;
M. Piagnerelli, et al. 19. Fiber Optic Immunosensors for Cardio-Vascular Disease Diagnosis: Quantification of Protein C, Factor V Leiden, and Cardiac Troponin T in Plasma;
H.J. Kwon, et al. 20. Soft Gel Chromatography Column Analysis and Design for the Production of High Molecular Weight Blood Factors: Model Molecule Protein C;
Weiwei He, D.F. Bruley. 21. Development of an Economic Miniantibody Production Process for the Purification of Protein C (Anti-Coagulant/Anti-Thrombotic);
L.K. Korah, et al. Nitric Oxide Biology and Physiology. 22. Nitric Oxide Synthesis in Brain is Stimulated by Oxygen;
S.R. Thom, D.G. Buerk. 23. Oxygen Indirectly Regulates Nitric Oxide Availability;
P.E. James, et al. 24. Modeling the Regulation of Oxygen Consumption by Nitric Oxide;
K. Lamkin-Kennard, et al. Oxygen Measurement Methods and Applications. 25. Oxygen Sensor Design: Analysis and correction of Problems Associated With Zero Current, Stability and Structure;
C.J. Koch. 26. Computer Simulation of Oxygen Microelectrode Measurements in Tissues;
I. Toma-Daşu, et al. 27. Physiological Oxygen Measurement Using Oxygen Electrodes;
D.K. Harrison. 28. Accuracy of a Polarographic Electrode at High Oxygen Concentrations;
M.D. Rollins, et al. 29. Recessed Oxygen Electrodes: Getting More than PO
2;
D.G. Buerk. 30. Oxygen Distributions in Tissue Measured by Phosphorescence Quenching;
S.A. Vinogradov, et al. 31. Adapting and Validating an NIRS Device to Measure
In Utero Fetal Sheep Cerebral Oxygenation;
J.D. Reynolds, et al. 32. Detection of the Fast Neuronal Signal on the Motor Cortex Using Functional Frequency Domain Near Infrared Spectroscopy;
M. Wolf, et al. 33. Probing Rat Brain Oxygenation with Near-Infrared Spectroscopy (NIRS) and Magnetic Resonance Imaging (MRI);
Y. Chen, et al. 34. Variation in Blood Oxygenation and Cerebral pO
2 in a Mouse Model Measured by EPR Spectrometry;
M.P. Thomas, et al. 35. Functional Oxygen-17 Magnetic Resonance Imaging and Localized Spectroscopy;
C.D. Mateescu. 36. Development of a Retractor for Monitoring the Oxygenation State of Brain Tissue;
Y. Onodera, et al. 37. Mapping of Hemodynamics on the Human Calf with Near Infrared Spectroscopy and the Influence of the Adipose Tissue Thickness;
U. Wolf, et al. 38. EPR Imaging of Vascular Changes in Oxygen in Response to Carbogen Breathing;
W. Stein, et al. 39. Molecular Imaging by PET;
M. Reivich. Oxygen in Eye and Muscle Physiology. 40. Frequency Domain Imaging of Oxygen Tension in the Mouse Retina;
R.D. Shonat, A.C. Kight. 41. Oxygen Delivery to the Retina and Related Visual Pathology;
R.D. Shonat. 42. Activation of the Visual Cortex in Newborn Infants under Natural Sleep Using Multichannel Near-Infrared Spectroscopy;
T. Kusaka, et al. 43. Effect of Blood Flow On PvO
2-VO
2 Relation in Contracting
In Situ Skeletal Muscle;
H. Kohzuki, et al. 44. Oxygen Transport and Intracellular Bioenergetics on Stimulated Cat Skeletal Muscle;
S. Nioka, et al. 45. Muscle Oxygenation by Near Infrared Spectroscopy and Lactate Thresholds in Endurance Trained and Recreationally Active Cyclists;
M. Ladewig, et al. 46. Cardiac Output, Oxygen Consumption and Muscle Oxygen Delivery in Submaximal Exercise;
C.B. Wolff. Tissue Hypoxia/Ischemia 47. Non-Invasive PET and SPECT Imaging of Tissue Hypoxia Using Isotopically Labeled 2-Nitroimidazoles;
C.J. Koch, S.M. Evans. 48. Diffuse Optical Measurement of Hemoglobin and Cerebral Blood Flow in Rat Brain During Hypercapnia, Hypoxia and Cardiac Arrest;
J.P. Culver, et al. 49. Multiorgan Monitoring of Hemodynamic and Mitochondrial Responses to Anoxia and Cardiac Arrest in the Rat;
A. Kraut, et al. 50. Importance of Glomus Cell Plasma Membrane and Mitochondrial Membrane Potentials During Acute Hypoxia Signaling in the Rat Carotid Body;
A. Roy, et al. 51. Estimation of Hydroxyl Radicals Based on the Salicylate Trapping Method in Hippocampus of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) During Transient Ischemia and Recirculation;
H. Negishi, et al. 52. Effect of Hypoxia and Ischemia on Expression of Selected Genes in the Brain of Newborn Piglets;
T. Zaitseva, et al. 53. Brain Oxygenation During Cardiopulmonay Bypass and circulatory Arrest;
G. Schears, et al. 54. Expression of Angiopoietin-1 and -2 in the Rat Brain During Chronic Hypoxia and DE-Adaptation;
P. Pichiule, J.C. La Manna. 55. Hypoxia-Inducible Factor-1&agr; Accumulation in the Rat Brain in Response to Hypoxia and Ischemia is Attenuated During Aging;
J.C. Chavez, J.C. La Manna. 56. Lung Ischemia: Endothelial Cell Signaling by Reactive Oxygen Species;
A.B. Fisher, et al. 57. Near Infrared Spectroscopy (NIRS) Measurements During Global Cerebral Ischemia In Sheep;
A.A. Martinez-Coll, et al. 58. Simulations of Capillary Network Oxygen Transport During Transient Ischemia in the Presence and Absence of Tissue Myoglobin;
D. Goldman. 59. Cerebral Oxygenation During Chronic Obstructive Pulmonary Disease;
R. Jasani, et al. Functional Alterations in Blood Flow and Oxygenation 60. Physiology of Functional Activation;
J.A. Detre. 61. Nonlinear Analysis of Heart Rate Variability in Infants with Apparent Life-Threatening Events;
P. Lemmerling, et al. 62. The Effect of Nicotinamide & Hyperoxic Gases on Blood Glucose;
R.A. Richardson, M.W. Dewhirst. 63. Measurement of Tissue Oxygenation Index During the First Three Days in Premature Born Infants;
G. Naulaers, et al. 64. Simultaneous Measurement of Cerebral Tissue Oxygenation over the Adult Frontal and Motor Cortex During Rest and Functional Activation;
T.S. Leung, et al. 65. Dysfunctional Microvascular Conducted Response in Irradiated Normal Tissue;
M.W. Gaber, et al. 66. Oxygenation and Blood Concentration Changes in Human Subject Prefrontal Activation by Anagram Solutions;
B. Chance, et al. 67. Quantitation of the Concordance Between Cerebral Intravascular Oxygenation and Mean Arterial Blood Pressure for the Detection of Impaired Autoregulation;
G. Morren, et al. 68. Effects of Fluid Percussion Injury on Rat Brain Hemodynamics, Ionic, Electrical Activity and Energy Metabolism
In Vivo;
T. Manor, et al. Author Index. Subject Index.