Synopses & Reviews
The new field of applied genetic research, genetic toxicology and mutation research investigates the muta- genicity and cancerogenicity of chemicals and other agents. Permanent changes in genes and chromosomes, or genome mutations, can be induced by a plethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Mutagenesis research has two aims: (1) to understand the molecular mechanisms leading to mutations, and (2) to prevent a thoughtless introduction of mutagenic agents into our environment. Both aspects, namely, basic and applied, will be treated in the new series Advances in Mutagenesis Research.
Table of Contents
Contents: Evolution of DNA Sequence: Contributions of Mutational Bias and Selection to the Origin of Chromosomal Compartments.- Dynamic Banding for High-Resolution Analysis of Chromosomes and Assignment of DNA Replication Times.- Mutational Bias, Molecular Ecology, and Chromosome Evolution.- Automated Cytogenetics in the Study of Mutagenesis and Cancer.- Chromosome Aberrations of Blood Lymphocytes Induced by Low-Level Doses of Ionizing Radiation.- The Surveillance of Birth Defects in South America: I - The Search for Time Clusters: Epidemics.- II - The Search for Geographic Clusters: Endemics.- Individual Genetic Counseling or Eugenics.- The Use of Intact Mammalian Cells as Metabolic Activation Systems in Mutagenicity Tests.- Cytogenetics and Molecular Genetics of Cell Transformation in Vitro by Mutagens/Carcinogens.- Subject Index.