Antioxidants play an important role in the progression of major human degenerative diseases and conditions. This book covers antioxidants and their mechanisms of action; their role in a whole array of conditions including coronary heart disease, malignant disease, diabetes, cataracts, respiratory disease, cystic fibrosis, cognitive functions, and aging; their indicators for oxidative stress; and related consumer issues. In 32 chapters contributed by world authorities in antioxidants, the volume provides a comprehensive and up-to-date survey of the field.
Antioxidants play an important role in the progression of major human degenerative diseases and conditions. This book covers antioxidants and their mechanisms of action; their role in a whole array of conditions including coronary heart disease, malignant disease, diabetes, cataracts, respiratory disease, cystic fibrosis, cognitive functions, and aging; their indicators for oxidative stress; and consumer issues. The majority of chapters have been developed from papers presented at the 6th World Congress in Clinical Nutrition, held in Banff, Canada, July 1997.
Contributors
Preface
Acknowledgements
Foreword
SECTION 1 Antioxidatns and Their Mechanisms of Action
1. Nutritional Antioxidants and Disease Prevention: Mechanisms of Action, Dennis V. Parke
2. Potential Role of Antioxidant Vitamins, Tapan K. Basu
3. Immunological Role of Antioxidant Vitamins, Adrianne Bendich
4. The Effect of Antioxidants on the Production of Lipid Oxidation Products and Transfer of Free Radicals in Oxidized Lipid-Protein Systems, Nazlin K. Howell and Suhur Saeed
5. Regulation of the Low-density Lipoprotein Receptor by Antioxidants, Sebely Pal, Christina Bursill, Cynthia D.K. Bottema and Paul D. Roach
6. Carotenoid and Lipid/Lipoprotein Correlates of the Susceptibility of Low-density Lipoprotein to Oxidation in Humans, Stephen B. Kritchevsky, Thomas A. Hughes, John Belcher and Myron Gross
7. Antioxidation and Evolution: Dietary Restriction and Alterations in Molecular Processes, Angelo Turturro, Peter H. Duffy and Ronald W. Hart
SECTION 2 Food Factors as Antioxidants
8. Evaluation of the Contribution of Flavanols and Caffeine to the Anticarcinogenic Potential of Tea, Costas Ioannides
9. Antioxidant Effects of Plant Phenolic Compounds, Kevin D. Croft
10. Antioxidant Effects of Soybean Isoflavones, Gaoli Zheng and Shoumin Zhu
11. Action of Gingko biloba as an Antioxidant, Noriko Noguchi, Kimihiro Nishino, Eiichi Washio, Honglian Shi and Etsuo Niki
12. Whole Foods, Antioxidants and Health
SECTION 3 Coronary Heart Disease
13. Antioxidants and Their Role in Coronary Heart Disease Prevention, David Kritchevsky and Stephen B. Kritchevsky
14. Effect of Antioxidants on Atherogenesis, Fred A. Kummerow, Mohamedain M. Mahfouz and Qi Zhou
n 15 Flavonoids and Other Phytochemicals in Relation to Coronary Artery Disease, Samir Samman, Philippa M. Lyons Wall, and Efi Farmakalidis
16. Antioxidant Vitamins and Coenzyme Q10 in the Prevention and Treatment of Coronary Artery Disease and Diabetes, Ram B. Singh, Shanti S. Rastogi, Mahmood Moshiri and Hemmy N. Bhagvan
17. Fruit, Vegetables, and Antioxidants: Their Role in the Prevention of Cardiovascular and Other Diseases, Jayne V. Woodside, Ian S. Young and John W.G. Yarnell
SECTION 4 Malignant Disease
18. Antioxidants and the Prevention of Cancer, Peter Greenwald and Sharon S. McDonald
19. The Role of B-Carotene and Vitamin E in the Treatment of early Gastric Premalignant Lesions: Biochemical and Clinical Aspects, Yuriy V. Bukin and Vladimir A. Draudin-Krylenko
SECTION 5 Other Diseases
20. Oxidative Stress, Vitamin E. and Diabetes, Sushil K. Jain
21. An Investigation of in Vivo Antioxidant Status and DNA Damage in Patients with IDDM, Mary Hannon-Fletcher, Ciara Hughes, Maurice J. O'Kane, Kenneth W. Moles, Christopher R. Barnett and Yvonne A. Barnett
22. Nutrition and the Risk for Cataract, Allen Taylor, Paul Jacques and Esther Epstein
23. Reactive Oxygen Species and Age-related Macular Degeneration, Ravindra Nath, Amod Gupta, Rajendra Prasad, Surinder S. Pandav and Rajinder Kumar
24. Antioxidants and Respiratory Disease, Ian S. Young, Heather E. Roxborough and Jayne V. Woodside
25. Oxidative Stress and Antioxidants in Cystic Fibrosis, Lisa Wood, Clare Collins and Manohar Garg
26. The Influence of Antioxidants on Cognitive Decline in the Elderly, Walter J. Perrig, Pasqualina Perrig and Hannes B. Stahelin
27. Schizophrenia: Role of Oxidative Stress and Essential Fatty Acids, Ravinder Reddy and Jeffrey K. Yao
28. B-Amyloid and Oxidative Stress in the Pathogenesis of Alzheimer's Disease, Ralph N. Martins, Chin Wern Chan, Emma Waddington, Gerald Veurink, Simon Laws, Kevin Croft and A.M. Dharmarajan
SECTION 6 Indicators of Oxidative Stress
29. Isoprostanes: Indicators of Oxidative Stress in Vivo and Their Biological Activity, P. Quaggiotto and Manohar L. Garg
30. Indicators of Oxidative Stress, Antioxidants and Human Health, Maria Dusinska, Jan Lietava, Begona Olmedilla, Katarina Raslova, Susan Southon and Andrew R. Collins
SECTION 7 Consumer Issues
31. Consumer Issues in Relation to Antioxidants, Efi Farmakalidis
Index