Synopses & Reviews
Synopsis
Fungi produce many chemically diverse secondary metabolites whose biological roles largely remain elusive. Within the increasing number of sequenced fungal genomes several important genes involved in secondary metabolite formation have been identified. Most of these genes are clustered and their coordinated transcription is controlled in a complex way by both narrow pathway-specific regulators as well as broad global transcription factors responsive to environmental cues. In recent years it was discovered many of the newly identified gene clusters are silent under laboratory conditions suggesting that the biosynthetic potential of fungi is far from being exploited. Besides identifying novel bioactive metabolites from still unexplored sources, the activation of these gene clusters by several approaches may result in the discovery of new substances with antibiotic and pharmaceutical benefits. This book covers recent advances in the field of fungal secondary metabolisms ranging from methodologies to biological aspects and will include the latest knowledge on fungal molecular biology, genomics, and metabolomics. With the related volume by Professor Juan-Francisco Martin, where the most relevant and well-studied fungal secondary metabolites are compiled, this book provides a comprehensive overview of the state-of-the-art of research on fungal secondary metabolites.
Synopsis
Preface
Contributors
Chapter 1. Fungal Secondary Metabolites in the "OMICS" Era
Susanne Zeilinger, Carlos Garc a-Estrada, and Juan-Francisco Mart n
Chapter 2. Key Players in the Regulation of Fungal Secondary Metabolism
Benjamin P. Knox and Nancy P. Keller
Chapter 3. Epigenetics of Fungal Secondary Metabolism Related Genes
Ming-Yueh Wu and Jae-Hyuk Yu
Chapter 4. Genome Mining for Fungal Secondary Metabolic Gene Clusters
Grayson T. Wawrzyn, Mark A. Held, Sarah E. Bloch, and Claudia Schmidt-Dannert
Chapter 5. Metagenomics and Metatranscriptomics for the Exploration of Natural Products from Soil Fungi
Irshad Ul Haq and Jan Dirk van Elsas
Chapter 6. Metabolomics and Secondary Metabolite Profiling of Filamentous Fungi
Bernhard Kluger, Sylvia Lehner, and Rainer Schuhmacher
Chapter 7. Fungal Chemotaxonomy
Jens C. Frisvad
Chapter 8. Endophytic Fungi as a Source of Novel Metabolites
Fernanda O. Chagas, Andr s Mauricio Caraballo-Rodriguez, and M nica T. Pupo
Chapter 9. Fungal Secondary Metabolism in the Light of Animal-Fungus Interactions: From Mechanism to Ecological Function
Marko Rohlfs
Chapter 10. Fusarium Mycotoxins and Their Role in Plant-Pathogen Interactions
Gerhard Adam, Gerlinde Wiesenberger, and Ulrich G ldener
Chapter 11. Biosynthesis and Molecular Genetics of Peptaibiotics - Fungal Peptides Containing Alpha, Alpha - Dialkyl Amino Acids
Xiao-Yan Song, Bin-Bin Xie, Xiu-Lan Chen, Yu-Zhong Zhang