Synopses & Reviews
Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.
Synopsis
This book probes the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts, focusing on mechanisms of cellular trafficking and the role of variegated trafficking mechanisms in humans and animals.
Table of Contents
Preface.- Contents.- Note on Nomenclature.- Author Addresses.- Section 1Historical Introduction to Secreted Cell Stress Proteins as Signalling Proteins.- Chapter 1 Discovery of the Cellular Secretion of Cell Stress Proteins, Larry Hightower and Emily J. Noonan.- Chapter 2 Discovery of the Agonist Activities of Molecular Chaperones and Protein-Folding Catalysts, Brian Henderson.- Chapter 3 Identification of Cell Stress Proteins in Biological Fluids, A. Graham Pockley.- Section 2 Intracellular Trafficking of Molecular Chaperones and its Consequences.- Chapter 4 Hsp27 Phosphorylation Patterns and Cellular Consequences, Sergiy Kosteonko and Ugo Moens.- Chapter 5 Evidence on Cholesterol-Controlled Lipid Raft Interaction of the Small Heat Shock Protein