Synopses & Reviews
This text uses a case-study approach to present the fundamentals of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 32 cases, carefully selected to cover common diseases and important principles, are supplemented by clinical descriptions of each disease and a comprehensive discussion of the underlying pathophysiological mechanisms and associated enzymatic and chemical alterations in tissues and body fluids. The Second Edition differs from its predecessor in several respects. It features seven new chapters on diseases not covered before. The Biochemical Perspectives section of each chapter has been expanded to include pertinent information on the molecular biology of each disease. More chapters are written by authors from outside the U.S., and Dr. Glew has a new co-editor. The diseases covered include those caused by viruses (hepatitis B, HIV), microorganisms (diphtheria), environmental toxins (e.g. lead), cardiovascular abnormalities (myocardial infarction), genetic mutations (hereditary spherocytosis, Gaucher disease, sickle-cell anemia, chronic granulomatous disease), endocrine system disorders (hypertension, Cushing's syndrome), and nutritional deficiencies (rickets).
Chapters follow a consistent format. A detailed case report describes the history, pertinent clinical laboratory data, histological findings, and physical characteristics. It is followed by a diagnosis section, which covers biochemical structures and the formulae of enzyme-catalyzed reactions, and describes the definitive method for confirming diagnosis. A discussion of molecular perspectives provides a detailed account of the normal processes and reactions pertaining to the case, along with the mechanism of the disease. The therapy is summarized and the likely prognosis is outlined. Each chapter concludes with discussion questions and a brief bibliography listing informative reviews and key publications. This text is intended for medical schools where biochemistry is taught though the study of actual clinical cases, and will be useful to medical students, graduate students in the biomedical sciences, and practicing physians taking refresher courses.
Review
Praise for the First Edition:
"Before I was asked to review this book, I had heard very favorable comments from a colleague who was using it to supplement the material he was presenting in a first year biochemistry class in medical school. After having had a chance to review the book myself, I agree with his comments and highly recommend it as a supplementary text in biochemistry or pathophysiology courses."--American Journal of Pharmaceutical Education
Synopsis
This text uses a case-study approach to present core principles of biochemistry and molecular biology in the context of human disease. The thirty-three cases have been carefully chosen to cover key concepts and common diseases. Each chapter provides a specific patient report that includes relevant history, pertinent clinical laboratory data, physical findings, and subsequent diagnosis. This is followed by a comprehensive discussion of normal biochemical processes and reactions pertaining to the case, along with the pathophysiological mechanisms of the disease.
In this third edition of the book, a new co-editor has aided in the substantially revised and more targeted selection of cases. The whole volume is now clearly focused on intermediary metabolism and other topics central to biochemistry. There are new chapters on topics such as collagen structure, mitochondrial metabolism, and hyperhomocysteinemia and vascular disease. There is also more coverage of nutritional biochemistry, including new chapters on protein-calorie malnutrition, obesity, vitamin A deficiency, and iron metabolism.
The best cases were retained from the previous edition, and have been completely rewritten and updated to include recent advances in diagnostic biochemistry and the status of current therapies. Although the first edition was intended primarily for medical students, through the years the book has proven useful for a wide variety of students interested in the health science professions.
About the Author
Robert H. Glew, Ph.D., is Professor and Chairman of the Department of Biochemistry at the University of New Mexico School of Medicine.
Yoshifumi Ninomiya, Ph.D., M.D., is Professor and Chairman of the Department of Molecular Biology and Biochemistry at Okayama University Medical School, Japan.
Table of Contents
'I. Nucleic Acids, Viruses and Protein Structure and Function
1. Creatine Kinase Isoenzymes and the Diagnosis of Myocardial Infarction, Donald W. Mercer, Murray A. Varat, Robert M. Amory
2. Hereditary Spherocytosis, Hiroshi Ideguchi
3. Fragile X Syndrome Koji Narahara, Yuji Yokoyama
4. Human Immunodeficiency Viruses and the Acquired Immunodeficiency Syndrome, Steven Jenison, Brian Hjelle
5. Pertussis, Harvey R. Kaslow, Michael E. Pichichero
6. Fulminant Hepatitis B, Shunji Mishiro, Koichi Kanai, Mineo Kojima
7. Sickle Cell Anemia, Samuel Charache, Ajovi B. Scott-Emuakpor
II. Metabolism and Energetics
8. Glucose 6-Phosphate Dehydrogenase Deficiency, Ernest Beutler, Kevin Laubscher
9. Neonatal Hypoglycemia and the Importance of Gluconeogenesis, Ian R. Holzman, J. Ross Milley
10. Jaundice and Gallstone Diseases, Susumu Tazuma, Goro Kajiyama
11. Pernicious Anemia, Dorothy J. VanderJagt, Denis M. McCarthy
12. Pyruvate Dehydrogenase Complex Deficiency, David W. Jackson, William S. Hays
13. Biotin and Multiple Carboxylase Deficiency, Krishnamurti Dakshinamurti, Barbara Triggs-Raine
14. Lactose Intolerance, Beulab M.Woodfin, Sanjeev Arora
15. Systemic Carnitine Deficiency: A Treatable Disorder, Harbajan S. Paul, Gail Sekas
16. Diabetes Mellitus, Abbas E. Kitabchi, Joseph N. Fisher
III. Metabolism of Complex Molecules
17. Rhabdomyolysis and Acute Renal Failure, Kazuharu Murakami
18. Abetalipoproteinemia: A Disorder of Lipoprotein Assembly, Alan T. Remaley, Catherine M. Buley
19. Low-Density Lipoprotein Receptors and Familial Hypercholesterolemia, Simeon Margolis
20. Alport Syndrome (Hereditary Nephritis), Karl Tryggvason, Yoshifumi Ninomiya
21. Pancreatic Exocrine Insufficiency, Philip Reyes, William R. Galey, Jr.
22. Lead Poisoning, Ginji Endo, Shigeru Taketani
23. Peroxisomal Disorders: Zellweger Syndrome and Adrenoleukodystrophy, Yasuyuki Suzuki, Tadao Orii
24. Inborn Errors of Urea Synthesis, Saul W. Brusilow
25. Alpha-1 Antitrypsin Deficiency, Sarah Jane Schwartzenberg, Harvey L. Sharp
26. Gaucher Disease: A Sphingolipidosis, John K. Scariano, Robert H. Glew
27. I-Cell Disease, James P. Chambers, Julian C. Williams
28. Phenylketonuria: Biochemical Basis of a Clinically Heterogeneous Disorder, Alan T. Remaley
IV. Steroids
29. Cushing\'s Syndrome, B. Sylvia Vela
30. Rickets Caused by a Vitamin D Deficiency, Russell W. Chesney, Shermine Dabbagh
V. Aspects of Infection and Pharmacology
31. Management of Hypertension with Particular Attention to the Renin-Angiotensin System Yehuda Traub, Alvin P. Shapiro
32. Chronic Granulomatous Disease, Adrian J. Thrasher, Anthony W. Segal
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