Synopses & Reviews
The events of September 11, 2001 have clearly demonstrated that the future pathologies of warfare will increasingly affect noncombatant populations on a large scale and require new levels of treatment expertise. In Combat Medicine: Basic and Clinical Research in Military, Trauma, and Emergency Medicine, highly accomplished clinical and basic investigators concisely review the leading research issues confronting emergency and military medicine today. These experts begin by presenting the latest thinking about the molecular and cellular mechanisms of trauma-apoptosis, abnormalities in nitric oxide production, complement activation, and immune cell response to stressors-that lead to tissue damage, and then describe cutting-edge research aimed at understanding and reversing the consequent damage to major organs. The clinical conditions covered include hemorrhagic shock and resuscitation, ischemia-reperfusion injury, acute respiratory distress syndrome, thermal injury, inhalation injury, and traumatic brain injury. The authors discuss the natures of combat pathologies, current research, emerging treatments, red blood cell storage, and bioterrorism involving anthrax, smallpox, plague, and other infectious and toxic agents. Cutting-edge and timely, Combat Medicine: Basic and Clinical Research in Military, Trauma, and Emergency Medicine offers not only clinical and basic investigators, but also surgical and medical residents, a concise introduction to the principal clinical conditions encountered in emergency, disaster, and combat medicine, as well as an up-to-date statement of where our diagnostic and treatment programs now stand, and what we still need to learn for future preparedness.
Synopsis
This concise review of the leading research issues confronting emergency and military medicine today presents the latest thinking about the molecular and cellular mechanisms of trauma that lead to tissue damage, and then describes cutting-edge research aimed at understanding and reversing the consequent damage to major organs. The clinical conditions covered include hemorrhagic shock and resuscitation, ischemia-reperfusion injury, acute respiratory distress syndrome, thermal injury, inhalation injury, and traumatic brain injury. The authors discuss the natures of their pathologies, current research and emerging treatments, as well as red blood cell storage and bioterrorism involving anthrax, smallpox, plague, and other infectious and toxic agents.
Synopsis
"...reflects a modern approach to medical planning for war...a concise manual for those researching organ injury following trauma, toxic or infectious assaults." - British Journal of Surgery
Table of Contents
Part I. Basic Mechanisms
Apoptosis
Henry K. Wong
Nitric Oxide
Douglas D. Thomas, Katrina M. Miranda, Deborah Citrin, Michael G. Espey, and David A. Wink
The Microcirculation and Adhesion Molecules
Thomas M. Herndon
Heat Stress
Juliann G. Kiang and David E. McClain
Immune System
Madhusoodana P. Nambiar
Complement Inhibitors in Trauma
Sherry D. Fleming
Infections
Mark E. Polhemus and Kent E. Kester
Part II. Current Concepts
Hemorrhagic Shock and Resuscitation: Trauma Research at the Trauma Research and Readiness Institute for Surgery
Peter Rhee, Hasan B. Alam, and Geoffrey S. F. Ling
Ischemia/Reperfusion Injury
Terez Shea-Donohue, Jimie Anderson, and Christopher Swiecki
Acute Respiratory Distress Syndrome
Thomas P. Shanley, Bruce Grossman, and Hector R. Wong
Thermal Injury
Leopoldo C. Cancio and Basil A. Pruitt, Jr.
Inhalation Injury
Leopoldo C. Cancio and Basil A. Pruitt, Jr.
Traumatic Brain Injury
Abel D. Jarell, James M. Ecklund, and Geoffrey S. F. Ling
Red Blood Cell Storage
John R. Hess
Bioterrorism
Michael J. Roy
Index