Synopses & Reviews
'Development of novel vaccines' gives an overview from the tasks in basic research leading to the final product - the vaccine - and its application. Each chapter of the book deals with one important paradigm for the development of novel vaccines and furthermore, the inevitable tools required for this process. Contributions are prepared by teams of scientists, all of them experts in the field, therefore lighting the certain topics from different views. This volume is a must have for researchers engaged in vaccine development.
Synopsis
Covering the entire process of developing a vaccine--from early, basic research right up to the final product itself, and approaching the subject from a variety of perspectives, this volume will be required reading for researchers engaged in vaccine creation.
Synopsis
"Development of novel vaccines" gives an overview of the tasks in basic research leading to the final product - the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vaccine arena, the current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions.
Table of Contents
Preface.- 1. The immunological fundamentals (Şefik Şanal Alkan).- 2. Finding protective bacterial antigens (Guido Grandi, Eszter Nagy).- 3. Enhancing and tailoring the immunogenicity of vaccines with novel adjuvants (Christopher B. Fox, Benjamin Wizel, Steven G. Reed, Derek T. O'Hagan).- 4. Vaccine Delivery - beyond needles (Flyer).- 5. Employing live microbes for vaccine delivery (Holger Loessner, Astrid Schwantes, Matthias Hamdorf, Uliana Komor, Sara Leschner, Siegfried Weiss).- 6. Synthesizing vaccines with microbes (Michael Wacker, Danilo R. Casimiro).- 7. Purification and formulation: silent but important players in vaccine development (Robert Schlegl, Rainer Hahn).- 8. Cutting edge approaches towards novel and cross protective influenza vaccines (Ruth Arnon, Tamar Ben-Yedidia).- 9. Cutting edge approaches towards novel and cross-protective influenza vaccines (Kenny Roose, Michael Schotsaert, Karim El Bakkouri, Bert Schepens, Walter Fiers, Xavier Saelens).- 10. Examples of novel registered prophylactic vaccines, HPV & JEV (Katrin Dubischar-Kastner, Michelle Vichnin, Carlos Sattler).- 11. The bumpy road towards vaccine registration - how to overcome regulatory hurdles (Michael Pfleiderer).