Synopses & Reviews
Diagnostic Hematology is a comprehensive guide to the laboratory diagnosis of blood and bone marrow diseases, including the use of flow cytometry for immunologic subclassification of leukemias and lymphomas. It presents a logical and systematic approach to diagnosis, based on the patterns derived from peripheral blood analysis, flow cytometry immunophenotyping studies and bone marrow examination. The book presents each diagnostic problem as it would be investigated in practice and takes the reader step-by-step through the process of reaching the differential diagnosis. It gives advice on the proper approach to diagnostic work-up and on how to avoid common diagnostic pitfalls. The patterns formed by different blood and bone marrow disorders are described in detail and illustrated with color photomicrographs and flow cytometry graphics. A free companion CD-ROM featuring 200 actual cases allows the user to assess real test results and see the patterns which lead to the final interpretation in each case.
Synopsis
Diagnostic hematology is a problem-solving process involving the gathering and analysis of the relevant findings in each case. Based on the combination of clinical and laboratory data, an experienced diagnostician can formulate the overall 'pattern' of a case. The 'pattern approach' to differential diagnosis is an integral component of the diagnostic reasoning of many expert hematologists.In this unique textbook the authors present a logical and systematic approach to diagnosis, based on the patterns derived from peripheral blood analysis, flow cytometry immunophenotyping studies and bone marrow examination. Unlike standard textbooks which are organized by specific diseases and thereby assume the reader has reached a diagnosis, this text presents the diagnostic problem as it is investigated in practice.The patterns formed by different blood and bone marrow disorders are described in detail and illustrated with color photomicrographs, or flow cytometry graphics. The reader is taken through the process of reaching the differential diagnosis. Advice is given on the proper approach to diagnostic work-up and how to avoid common diagnostic pitfalls. The companion CD-ROM, with full instructions given in the appendix, offers the reader the chance to assess real test results, and see the patterns which lead to the final interpretation in over 200 cases.As a result the reader will develop the skill of pattern recognition and be able to incorporate this diagnostic approach in practice. This is an essential text for physicians practicing hematology and hematopathology, especially those interpreting peripheral blood, flow cytometry and bone marrow specimens; also for technologists and laboratory staff responsible for the screening of full blood counts, the initial review of blood/bone marrow films or immunophenotyping data.System requirements: Windows 95, Windows 98 or Windows NT. Screen resolution of 800 x 600 with 16 million colours (24-bit). Minimum display: at least 65,000 colours (16-bit).
Description
System requirements for accompanying computer disc: Windows 95, Windows 98 or Windows NT. Includes bibliographical references and index.
Table of Contents
Part 1: Peripheral Blood
Approach to the peripheral blood
Normal peripheral blood morphology
Neutrophilia pattern
Leukoerythroblastic pattern
Abnormal mononuclear cell pattern
Erythrocytosis pattern
Thrombocytosis pattern
Absolute lymphocytosis pattern
Thrombocytopenia pattern
Eosinophilia pattern
Monocytosis pattern
Bicytopenia pancytopenia pattern
Neutropenia/leukopenia pattern
Hypochromia/microcytosis pattern
Macrocytosis pattern
Normochromic, normocytic anemia pattern
Anemia with anisocytosis pattern
Leukemoid pattern
Nonspecific pattern
Part 2: Flow Cytometry
Approach to flow cytometry: Stem cell pattern
Myeloid pattern
Erythroid pattern
Megakaryocytic pattern
Immature B-cell pattern
Immature T-cell pattern
Mature B-cell pattern
Mature T-cell pattern
Plasma cell pattern
Nonspecific pattern
No pattern established
Part 3: Bone Marrow
Approach to the bone marrow
Normocellular marrow pattern
Hypocellular marrow pattern
Erythroid preponderance/hyperplasia pattern
Hypercellular marrow, myeloid preponderance/hyperplasia pattern
Megakaryocytic hyperplasia pattern
Bihyperplasia/panhyperplasia pattern
Bone marrow lymphocytosis/plasmacytosis pattern
Mononuclear cell infiltration pattern
Foreign cell infiltration pattern
Granulomata/histiocytic proliferation pattern
Suggested reading.