Synopses & Reviews
Stands as the most comprehensive guide to the subject?covering every essential topic related to DNA damage identification and repair.
Covering a wide array of topics from bacteria to human cells, this book summarizes recent developments in DNA damage repair and recognition while providing timely reviews on the molecular mechanisms employed by cells to distinguish between damaged and undamaged sites and stimulate the appropriate repair pathways.
about the editors...
WOLFRAM SIEDE is Associate Professor, Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth.? He received the Ph.D. degree (1986) from Johann Wolfgang Goethe University, Frankfurt Germany.
YOKE WAH KOW is Professor, Department of Radiation Oncology, Emory University School of Medicine, Atlanta, Georgia.? He received the Ph.D. degree (1981) from Brandeis University, Waltham, Massachusetts.
PAUL W. DOETSCH is Professor, Departments of Biochemistry, Radiation Oncology, and Hematology and Oncology, and Associate Director for Basic Research, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia.? He received the Ph.D. degree (1982) from Temple University School of Medicine, Philadelphia, Pennsylvania.
Synopsis
This reference focuses on the various molecular mechanisms and structural aspects involved in the process of DNA damage recognition and repair, as well as other related responses such as damage tolerance and cell cycle checkpoint regulation. When available, this guide shows how protein/DNA damage contacts have been accomplished and which types of structural features or consequences of DNA damage have been probed by the recognition apparatus in order to permit a distinction from undamaged DNA. In this fashion, damage recognition is addressed within the major pathways of DNA repair. The book analyzes the pathways of damage tolerance as a consequence of a combined recognition/accommodation process and also includes chapters on translesion synthesis.