Synopses & Reviews
The processes of DNA recombination and repair are vital to cell integrity -- an error can lead to a disease such as cancer. These processes are therefore expanding areas of research and are now being taught in many undergraduate and postgraduate courses. Filling a need for timely and accurate information on the subject, this book studies the cellular processes involved in DNA recombination and repair by highlighting a selection of issues currently at the forefront of understanding. Chapters address genome integrity as it is important to health, and authors include the relevance of DNA repair and recombination to ill health and cancer in particular. As well, molecular pathways of apoptosis induction are clearly referenced whenever necessary. DNA Recombination and Repair will undoubtedly benefit advanced students and professionals and will likely interest anyone intrigued by the processes of DNA.
Review
"An overview of current knowledge on DNA recombination and repair. Topics covered include DNA structure and folding dynamics, features of recognition and cleavage of signal sequences impact upon double strand break repair, strategies for dealing with DNA mismatches or lesions, the enzymology of excision repair, and the integration of DNA repair into other cellular pathways."--SciTech Book News
Table of Contents
List of contributors
Abbreviations
1. Molecular processing of DNA folding anomalies in Escerichia coli, David R. F. Leach
2. Double-strand break repair and V(D)J recombination, Belinda K. Singleton and Penny A. Jeggo
3. Translesion replication, Christopher Lawrence and Roger Woodgate
4. Mismatch repair and cancer, P. Karran and M. Bignami
5. Enzymology of human nucleotide excision repair, Hanspeter Naegeli
6. Transcription-coupled and global genome repair in yeast and humans, Marcel Tijsterman, Richard A. Verhage, and Jaap Brouwer
7. The ATM gene and stress response, Martin F. Lavin and Kum Kum Khanna
8. p53 and the integrated response to DNA damage, Paul J. Smith and Christopher J. Jones
Index