Synopses & Reviews
This comprehensive Sixth Edition of this well-known text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new edition continues to include a thorough description of drug discovery and pharmacodynamic agents and integrates traditional principles in medicinal chemistry with pharmacology and therapeutics. The new emphasis is firmly placed on pharmaceutical care that focuses on the patient, and on the pharmacist as a therapeutic consultant, rather than a chemist. Respected academic and research professionals from around the world have contributed to this exhaustive reference, yet a consistent style and format are present throughout for simplified navigation.
Review
andquot;This is still the gold standard against which all other medicinal chemistry books must be judged. It is content rich, yet attempts to relate the discipline to modern clinical practice. It is comprehensive and accessible, and an excellent resource for students as well as professionals seeking to update their knowledge. The addition of the clinical significance sections alone justifies replacing the previous edition.andquot;
and#160;
and#160;- Doody Enterprises, Inc. (June 2012)
and#160;and#160; - Michael R. Borenstein, PhD(Temple University School of Pharmacy)
and#160;
Synopsis
The Sixth Edition of this well-known text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. Emphasis is on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist.
A new disease state management section explains appropriate therapeutic options for asthma, chronic obstructive pulmonary disease, and men's and women's health problems. Also new to this edition: Clinical Significance boxes, Drug Lists at the beginning of appropriate chapters, and an eight-page color insert with detailed illustrations of drug structures.
Case studies from previous editions and answers to this edition's case studies are available online at thePoint.
Synopsis
This comprehensive Fifth Edition has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new emphasis is on pharmaceutical care that focuses on the patient, and on the pharmacist a therapeutic clinical consultant, rather than chemist. Approximately 45 contributors, respected in the field of pharmacy education, augment this exhaustive reference. New to this edition are chapters with standardized formats and features, such as Case Studies, Therapeutic Actions, Drug Interactions, and more. Over 700 illustrations supplement this must-have resource.
Synopsis
Acclaimed by students and instructors alike, Foye's Principles of Medicinal Chemistry is now in its Seventh Edition, featuring updated chapters plus new material that meets the needs of today's medicinal chemistry courses. This latest edition offers an unparalleled presentation of drug discovery and pharmacodynamic agents, integrating principles of medicinal chemistry with pharmacology, pharmacokinetics, and clinical pharmacy.
All the chapters have been written by an international team of respected researchers and academicians. Careful editing ensures thoroughness, a consistent style and format, and easy navigation throughout the text.
Table of Contents
Historical Perspective of Medicinal Chemistry
Part I: Principles of Drug Discovery
- Chapter 1. Drug Discovery from Natural Products
- Chapter 2. Drug Design and Relationship of Functional Groups to Pharmacologic Activity
- Chapter 3. Molecular Modeling and in Silico
- Chapter 4. Receptors and Drug Action
- Chapter 5. Drug Discovery Through Enzyme Inhibition
- Chapter 6. Pharmaceutical Biotechnology-From Nucleic Acids to Personalized Medicine
- Chapter 7. Peptide and Protein Drugs
- Chapter 8. Antisense Therapeutic Agents
- Chapter 9. Physicochemical and Biopharmaceutical Properties of Drug Substances and Pharmacokinetics
- Chapter 10. Drug Metabolism
- Chapter 11. Drug Regulation: An Overview
Part II: Drug Receptors Affecting Neurotransmission and Enzymes as Catalytic Receptors
- Overview of Drug Receptors: A Perspective
- Chapter 12. Drugs Affecting Cholinergic Neurotransmission
- Chapter 13. Adrenergic Receptors and Drugs Affecting Adrenergic Neurotransmission
- Chapter 14. Serotonin Receptors and Drugs Affecting Serotonergic Neurotransmission
- Chapter 15. Amino Acid Neurotransmitters in the Central Nervous System
- Chapter 16. Inhibitors of Nerve Conduction: Local Anesthetics
- Chapter 17. Phosphodiesterase Inhibitors
Part III: Pharmacodynamic Agents
Section 1: Drugs Affecting Central Nervous System
- Chapter 18. General Anesthetics
- Chapter 19. Sedative-Hypnotics
- Chapter 20. Antiseizure Agents
- Chapter 21. Antidepressants
- Chapter 22. Psychotherapeutic Drugs: Antipsychotic and Anxiolytic Agents
- Chapter 23. Hallucinogens, Stimulants and Related Drugs of Abuse
- Chapter 24. Opioid Analgesics
- Chapter 25. Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonian and Spasmolytic Agents
Section 2: Drugs Affecting the Cardiovascular System
- Chapter 26. Cardiac Agents: Cardiac Glycosides, Antianginal, and Antiarrhythmic Drugs
- Chapter 27. Diuretics
- Chapter 28. Angiotensin Converting Enzyme Inhibitors, Antagonists and Calcium Blockers
- Chapter 29. Central and Peripheral Sympatholytics and Vasodilators
- Chapter 30. Antihyperlipoproteinemics and Inhibitors of Cholesterol Biosynthesis
- Chapter 31. Antithrombotics, Thrombolytics, Coagulants, and Plasma Extenders
Section 3: Drugs Affecting the Hormonal Systems
- Chapter 32. Insulin and Drugs Used for the Treatment of Diabetes
- Chapter 33. Adrenocorticoids
- Chapter 34. Thyroid Function and Thyroid Drugs
- Chapter 35. Calcium Homeostasis
Section 4: Drugs Affecting the Immune Systems - Chapter 36. Nonsteroidal Anti-Inflammatory Drugs
- Chapter 37. Antihistamines and Related Antiallergic and Antiulcer Agents
Section 5: Chemotherapeutic Agents
- Chapter 38. Antibiotics and Antimicrobial Agents
- Chapter 39. Antiparasitic Agents
- Chapter 40. Antifungal Agents
- Chapter 41. Antimycobacterial Agents
- Chapter 42. Cancer and Chemotherapy
- Chapter 43. Antiviral Agents and Protease Inhibitors
Part IV: Disease State Management
- Chapter 44. Asthma and Chronic Obstructive Pulmonary Disease
- Chapter 45. Men' Health
- Chapter 46. Women's Health
Appendix A: pKa Values for Some Drugs and Miscellaneous Organic Acids and Bases
Appendix B: pH Values for Tissue Fluids