Synopses & Reviews
The book deals with the role of both oxygen- and nitrogen-centred free radicals in inflammatory diseases such as rheumatoid arthritis. The well-known involvement of the superoxide anion radical in the bactericidal action of inflammatory cells suggests that radicals and the inflammatory response are inextricably linked. The widespread involvement of radicals in human disease seems inevitable, because inflammation is such a conspicuous component of human disease. For the first time, the present text integrates contributions from leading research groups who have been investigating the role of radicals within the context of all stages of inflammtion, such as the recruitment of inflammatory cells, their bactericidal action, inflammatory tissue destruction and inflammatory cell death by apoptosis. The chapters are broadly organised so that they trace the clinical course of the acute and chronic inflammtory response, emphasising the therapeutic implications of recent data on the contribution of nitric oxide and related nitrogen-centred species. The book will be of interest to academic and industrial researchers and clinicians with interests in the fields of inflammation or free radical biology.
Synopsis
Reactive oxygen/nitrogen species and acute inflammation: A physiological process.- Free radicals and pathology: current concepts.- The NADPH oxidase of neutrophile and other cells.- Nitric oxide - a novel antimicrobial agent.- Xanthine oxidoreductase.- Inflammatory mediators free radicals and gene transcription.- Reactive metabolites of oxygen and nitrogen adhesion molecule expression and chronic joint inflammation.- Role of thioredoxin in the redox regulation of gene expression in inflammatory diseases.- Reactive oxygen species and the regulation of metalloproteinase expression.- Nitric oxide and inflammatory joint diseases.- Nitric oxide and bone destruction.- Why does chronic inflammation persist? A radical autoimmune perspective.- Radicals granuloma formation and fibrosis.- Reactive oxygen species nitric oxide and apoptosis.- Evolving measurements of radical products - how much do they tell us about inflammation?.- Do antioxidants have a role in the therapy of human inflammatory diseases?.