Synopses & Reviews
Synopsis
Excerpt from Fy 1998 Annual Report of Intramural Research Program Activities of the National Institute on Alcohol Abuse and Alcoholism
Approximately 50% of our perpetrators were exposed to violence growing-up. This led to the hypothesis that exposure to violence could alter the central noradrenergic function. Oi-some perpetrators. Previous studies have shown that subjects with post traumatic stress disorder (ptsd) have disturbances in norepinephrin'e metabolism that predispose them to over-react to stimuli which they perceived as threatening. To explore this possibility, we employed the alpha-2 adrenergic antagonist, yohimbine, to study adrenergic receptor function in perpetrators and non-violent controls. The study has been completed and the results are being analyzed.
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