Synopses & Reviews
Rapid advances in the field of molecular genetics have occurred since Genes V was first published in 1993. Reflecting these advances, GENES VI has been thoroughly updated with the latest thinking and research in the field. The content of GENES VI has been extensively updated and restructured throughout. There are fewer tables and those that remain have been simplified. Many figures have been redrawn and many replaced to present key concepts more distinctly than ever before. With a revised full color design, dozens of new figures, a more extensive list of suggested readings, the support of companion CD-ROM software, and a 360-question problem set, this widely used volume provides the most current and comprehensive information available in genetics today.
About the Author
After obtaining his degrees at the University of Cambridge, Dr. Benjamin Lewin was the founding editor of the journal cell, now one of the leading international journals in life science. As editor of cell, he is concerned with reviewing current research in molecular and cellular biology. In addition to writing Genes VI, he is the author of a three-volume series of advanced books on Gene expression.
Table of Contents
INTRODUCTION
Cells as macromolecular assemblies
1. Proteins
2. Compartments
PART 1
DNA as information
3. Genes are mutable units
4. DNA is the genetic material
5. Nucleic acid structure
6. Isolating the gene
PART 2
From gene to protein
7. Messenger RNA
8. Protein synthesis
9. Interpreting the genetic code
10. Protein localization
PART 3
Prokaryotic gene expression
11. Transcription
12. The operon
13. Phage strategies
PART 4
Perpetuation of DNA
14. The replicon
15. DNA replication
16. Restriction and repair
17. Recombination
18. Transposons
19. Retroviruses and retroposons
PART 5
The eukaryotic genome
20. DNA biotechnology
21. Genomes
22. Exons and introns
23. Gene numbers
24. Organelle genomes
25. Simple sequence DNA
26. Chromosomes
27. Nucleosomes
PART 6
Eukaryotic gene expression
28. Initiation of transcription
29. Regulation of transcription
30. Nuclear splicing
31. Catalytic RNA
32. Rearrangement of DNA
33. Immune diversity
PART 7
Cell growth, cancer, and development
34. Protein trafficking
35. Signal transduction
36. Cell cycle and growth regulation
37. Oncogenes and cancer
38. Gradients and cascades
Epilogue
Landmark shifts in perspective