Synopses & Reviews
Oxford University Press is proud to present GENES VII--the latest edition of Benjamin Lewin's best-selling textbook. This authoritative work provides an integrated account of the structure and function of genes and incorporates all the latest research in the field.
THE MOST SIGNIFICANT REORGANIZATION TO DATE
The power of direct analysis of the genome has made a significant difference in the approach of GENES VII. In a departure from previous editions, which started with a traditional analysis of formal genetics, the new edition begins with the molecular properties of the gene itself. The text is now reorganized to begin with the concept of genes as a segment of DNA coding for protein, and then proceeds directly to the characterization of the genome in terms of its content of genes.
INTEGRATED APPROACH
GENES VII first explains the structure and function of the gene as a means to revealing the operation of the genome as a whole, and offers an integrated approach to prokaryotes and eukaryotes. The gene is considered from all aspects, including:
* Basic forms
* The numbers and relationships among genes in a genome
* Their packaging into chromosomes
* The process of gene expression from transcription through translation
* The reproduction and safeguarding of the gene structure
* Aspects of the overall circuitry through which genotype determines phenotype
STREAMLINED, FULL-COLOR DESIGN
GENES VII has been considerably restructured and reorganized to highlight the latest research and technology. It contains more than 800 full color illustrations that are extremely useful in teaching the key concepts presented in the book.
GENES VII CONTAINS NEW, GROUNDBREAKING INFORMATION ON:
* New technologies that count and compare expressed genes
* Accessory proteins (chaperones)
* The role of the proteasome
* Licensing
* Reverse translocation
* Connections between repair and recombination systems and human diseases
* Connections between the structure of chromosomal material and control of gene expression in eukaryotes
* The process of X chromosome inactivation
* Imprinting
* Control of gene expression by epigenetic changes
* The enzymatic activities that control chromatin structure and affect the regulatory process
* Archeael enzymes
* The mechanism of RNA editing in lower eukaryotes
* The role of RAG genes
* Interactions within and between pathways
* The use of protein degradation to control passage through the cell cycle
* Programmed cell death
* Telomerase and its role in carcinogenesis. And much more!
Synopsis
The definitive textbook of molecular genetics.
Genes VII, the latest edition of this well-respected and best-selling textbook, covers the material that is at the heart of current courses in molecular biology, genetics, cell biology, and related disciplines. In a change to the approach of all previous editions, which started with a traditional analysis of formal genetics, the seventh edition presents the subject in the context of the eukaryotic gene as revealed in the last decade, an analysis based directly on the molecular properties of the gene itself. The new approach has made the book more concise and a new design presents the material in a refreshingly clear manner.
Genes VII gives an integrated account of the structure and function of genes in both prokaryotic and eukaryotic organisms.
Important features of the text include:
- An extensively updated and restructured content to reflect modern thinking
- Revised layout which presents the most current research even more clearly and concisely
- Direct analysis of the genome in terms of its content of genes
- Over 800 full colour graphics to illustrate important concepts
- Overview figures that summarize large amounts of work
- Free access to all illustrations on www.oup.com/genesvii, making learning and teaching from this book even easier
Synopsis
Genes V gives an integrated account of the structure and function of genes in both prokaryotic and eukaryotic organisms. It is thoroughly up-to-date with the latest thinking and research in the field. Successive editions have provided an integrated account of the whole field of modern molecular genetics and this edition continues that approach, providing a new synthesis with a much greater emphasis on how genes function in their biological context. The book begins with an introductory overview of material that the student should have encountered in previous courses. These first two chapters consider the cell as an assembly of macromolecules, reviewing the function of these molecules and how they are organized into cell organelles. There follows a detailed examination of the role and function of DNA with increased emphasis on genetic mapping in the context of human disease. The third part of the book discusses translation and has been thoroughly updated to reflect new knowledge about structure and the specificity on DNA function. A new section on cell biology follows. This brings together much information that was scattered in previous editions of the book and integrates it with new knowledge on protein transport, signal transduction, and the cell cycle. The section on gene expression has been thoroughly modernized and updated as have the two chapters which follow, one of which gives an entirely new account of gene sizes, organization and differences in eukaryotes. The book gives, for the first time, a unifying concept for eukaryotic transcription and its regulation reflecting work done since 1990. The chapter on recombination has been entirely rewritten and is followed by updated coverage of manipulations of DNA: transposons, retroviruses, and rearrangements. The book concludes with chapters examining in detail the role of genes in some of the key areas of molecular biology research, molecular immunology, development, and oncogenesis. Changes in the content of the book, which have given it greater coherence and a much more logical structure, are reflected by a new design bringing greater clarity, there are fewer tables and those that remain have been redesigned and simplified. All figures have been redrawn in a modern style using state-of-the-art graphics in full color.
Synopsis
What is a gene? How is it reproduced? How is it expressed? What controls its expression? This widely used text provides the most current and comprehensive information available in genetics today. Since its first publication in 1983, Genes has been acknowledged as a leader in the field, both as a textbook and as a resource. Through an integrated approach to prokaryotic and eukaryotic biology, it is able to discuss topics in molecular biology and genetics in terms of the approaches actually used by researchers. For this edition, the text has been significantly expanded, thoroughly revised and updated, and further enhanced with the addition of 300 new figures. Two entirely new chapters deal with exciting developments in protein trafficking and eukaryotic gene transcription. A new, extensive introduction to molecular and cell biology now provides essential background material to students, and new end-of-chapter summaries reinforce the major points of each section. Each of the nine major parts of the text is self-contained, allowing maximum flexibility to instructors. The new, larger format ensures greater ease or reading and even sharper illustrations.
About the Author
After obtaining his degrees at the University of Cambridge, Dr. Benjamin Lewin was the founding editor of the journal cell, now one of the leading international journals in life science. As editor of cell, he is concerned with reviewing current research in molecular and cellular biology. In addition to writing Genes VI, he is the author of a three-volume series of advanced books on Gene expression.
Table of Contents
INTRODUCTION
Cells as macromolecular assemblies
1. Proteins
2. Compartments
PART 1
DNA as information
3. Genes are mutable units
4. DNA is the genetic material
5. Nucleic acid structure
6. Isolating the gene
PART 2
From gene to protein
7. Messenger RNA
8. Protein synthesis
9. Interpreting the genetic code
10. Protein localization
PART 3
Prokaryotic gene expression
11. Transcription
12. The operon
13. Phage strategies
PART 4
Perpetuation of DNA
14. The replicon
15. DNA replication
16. Restriction and repair
17. Recombination
18. Transposons
19. Retroviruses and retroposons
PART 5
The eukaryotic genome
20. DNA biotechnology
21. Genomes
22. Exons and introns
23. Gene numbers
24. Organelle genomes
25. Simple sequence DNA
26. Chromosomes
27. Nucleosomes
PART 6
Eukaryotic gene expression
28. Initiation of transcription
29. Regulation of transcription
30. Nuclear splicing
31. Catalytic RNA
32. Rearrangement of DNA
33. Immune diversity
PART 7
Cell growth, cancer, and development
34. Protein trafficking
35. Signal transduction
36. Cell cycle and growth regulation
37. Oncogenes and cancer
38. Gradients and cascades
Epilogue
Landmark shifts in perspective