Synopses & Reviews
Synopsis
Part A. Causes, Biological and Molecular bases of HCC
Chapter 1. Epidemiology of Hepatocellular Carcinoma - Donna L. White, Fasiha Kanwal, Li Jiao and Hashem B. El-Serag
Chapter 2. Environmental Carcinogens and Risk for Human Liver Cancer - John D. Groopman
Chapter 3. Molecular Mechanisms of Hepatocellular Carcinoma - Hani Alotaibi, Nese Atabey, Kasım Diril, Esra Erdal and Mehmet Ozturk
Chapter 4. Chemically-Induced Hepatocarcinogenesis - Yvonne P. Dragan
Chapter 5. Molecular Profiling of Human Hepatocellular Carcinoma - Anuradha Budhu and Xin Wei Wang
Chapter 6. Genomic signatures of risk factors and molecular identification of HCC subtypes - Jean-Charles Nault and Jessica Zucman-Rossi
Chapter 7. MicroRNAs and hepatocellular carcinoma - Aldo Cavallini
Chapter 8. Non-tumor prognostic factors in hepatocellular carcinoma - Nicolas Goossens, Ismail Labgaa and Augusto Villanueva
Chapter 9. Gut microbiota and HCC - Sven H. Loosen, Christoph Roderburg and Tom Luedde
Chapter 10. Hepatocellular Carcinoma as a Paradigm for a Systemic Evolutionary Approach to Cancer - Antonio Mazzocca, Giovanni Ferraro, Giovanni Misciagna and Brian I. Carr
Chapter 11. HCC and its Microenvironment - Brian I. Carr
Chapter 12. Circulating tumor cells (Liquid Tumor Biopsy) in hepatocellular carcinoma: biology, methodologies, and clinical implications - Zhengfen Yin
Chapter 13. Role of the immune system in hepatocellular carcinoma: Implications for existing and novel therapies - Tobias Flecken and Robert Thimme
Chapter 14. Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma - Evgeny V. Denisov, Tatiana S. Gerashchenko, Marina V. Zavyalova, Vasiliy N. Manskikh, Evgeny L. Choinzonov, Nadezhda V. Cherdyntseva and Vladimir M. Perelmuter Chapter 15. Systemic inflammation: a new prognostic domain and source of therapeutic targets in hepatocellular carcinoma - David J. Pinato and Rohini Sharma
Chapter 16. Hepatocellular Carcinoma Associated with Hepatitis B virus - Inbal Houri and Oren Shibolet
Chapter 18. Obesity, NASH and HCC - Chadia L. Robertson, Devanand Sarkar and Arun J. Sanyal
Chapter 19. Metabolic Disease and Hepatocellular Carcinoma - David H. Van Thiel, Salamah Mohammad Alwahsh and Giuliano Ramadori
Part B. DiagnosisChapter 20. Pathologic Aspects of Hepatocellular Tumors - Michael A. Nalesnik
Chapter 21. Protein biomarkers in the management of hepatocellular carcinoma: Novel combinatory approaches - Philip Johnson and Sarah Berhane
Chapter 22. Surveillance for hepatocellular carcinoma - Cristina Della Corte and Massimo Colombo
Chapter 23. Use of Imaging Techniques to Screen for Hepatocellular Carcinoma - Satoshi Goshima
Chapter 24. Ultrasound of Hepatocellular Carcinoma: The Important Contribution of Contrast Enhancement - Tae Kyoung Kim, Hyun-Jung Jang and Stephanie R. Wilson
Chapter 25. MRI for Detection and Evaluation of Hepatocellular Carcinoma - Anuj Patel, Neil Malhotra, Christopher G. Roth, Sandeep Deshmukh and Donald G. Mitchell
Chapter 26. Computed Tomography of HCC - Francesco Agnello and Giuseppe Brancatelli
Chapter 27. Clin
Synopsis
- Hepatocellular carcinoma (HCC) used to be regarded as a rare disease. However, the increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology are changing. During this exciting time in the field of HCC basic science and clinical management, many changes are simultaneously occurring at multiple levels of our understanding and management of the disease. Suddenly, there are several new choices of therapy to offer patients. Hepatocellular Carcinoma, 3rd edition addresses this fast-changing disease and gives the reader a clearer understanding of the many mechanisms involved in carcinogenesis of the liver. This comprehensive and detailed review of how to diagnose and treat hepatocellular carcinoma is written by international leaders in the field, covering both clinical treatment choices and the basic science underlying HCC development. Updated and enhanced from the last edition in 2009, Hepatocellular Carcinoma, 3rd edition features 12 new chapters including discussion of molecular markers, molecular hepatocarcinogenesis, microenvironment, heterogeneity, the new and exciting contributions of immunotherapy, and updates on the major effective hepatitis therapies that will transform HCC incidence and perhaps also the therapy. This cutting-edge text is a vital resource and must-have for today's hepatologists and medical and surgical oncologists.
This is a well written text and should be a good reference book for those who see patients with HCC.. - Practical Gastroenterology
...a useful tool for both physicians and surgeons with a specific interest in the management of patients with HCC. - Digestive and Liver Disease