Synopses & Reviews
The reviews compiled in this volume deal with various aspects of virus-host interaction which are hoped to provide clues as to how to manage Herpes simplex virus from an immunobiological perspective. After as brief overview of the regulation of gene expression by HSV, a series of chapters followon pathogenesis and the role of different aspects of specific and natural immunity at controlling HSV in different disease situations. The important topic of HSV as common cause of blindness, in which the immune response appears to play a pathological role, is also discussed. The final chapters deal with current progress in developing convention vaccines against HSV, and the novel approach of intracellular immunization and its possible application to HSV.
Although upstaged by the tragic appearance of the human immunodeficiency virus, herpes simplex viruses (HSV) types 1 and 2 continue to be major human pathogens against which we lack acceptable vaccines or other means of immunological control. The virus is large and complex, coding for 70 or more proteins. Although many mysteries remain to be unraveled, our knowledge base regarding genomic organization, gene expression and regulation, pathogenesis, and immune recog- nition of component parts is quite considerable. Indeed, meet- ings devoted entirely to herpesviruses are conspicuous by their frequency and excellent, yet sometimes exclusive, attendance. The purpose of this volume is to compile in a single book a series of reviews by leading investigators that deal with various aspects of virus-host interactions and which hopefully will pro- vide clues as to how to best manage HSV from an immunobio- logical perspective. Ultimately, one anticipates that a full under- standing of virus-host interaction will lead to strategies useful for the prevention and control of HSV. The state of current progress with conventional vaccines is presented, as is a chapter on intracellular immunization. This latter novel approach to virus infections comes at approximately the bicentenary of Jenner's introduction of a successful conventional immunization strategy.