Synopses & Reviews
This book deals with infectious diseases -- viral, bacterial, protozoan and helminth -- in terms of the dynamics of their interaction with host populations. The book combines mathematical models with extensive use of epidemiological and other data. This analytic framework is highly useful for the evaluation of public health strategies aimed at controlling or eradicating particular infections. Such a framework is increasingly important in light of the widespread concern for primary health care programs aimed at such diseases as measles, malaria, river blindness, sleeping sickness, and schistosomiasis, and the advent of AIDS/HIV and other emerging viruses. Throughout the book, the mathematics is used as a tool for thinking clearly about fundamental and applied problems having to do with infectious diseases. The book is divided into two parts, one dealing with microparasites (viruses, bacteria and protozoans) and the other with macroparasites (helminths and parasitic arthropods). Each part begins with simple models, developed in a biologically intuitive way, and then goes on to develop more complicated and realistic models as tools for public health planning. The book synthesizes previous work in this rapidly growing field (much of which is scattered between the ecological and the medical literature) with a good deal of new material.
Description
Includes bibliographical references (p. [697]-735) and indexes.
Table of Contents
1. Introduction
2. A Framework for Discussing the Population Biology of Infectious Diseases
PART I: Microparasites
3. Biology of the Host-Microparasite Associations
4. The Basic Model: Statics
5. Static Aspects of Eradication and Control
6. The Basic Model: Dynamics
7. Dynamic Aspects of Eradication and Control
8. Beyond the Basic Model: Empirical Evidence of Inhomogeneous Mixing
9. Age-Related Transmission Rates
10. Genetic Heterogeneity
11. Social Heterogeneity and Sexually Transmitted Diseases
12. Spatial and Other Kinds of Heterogeneity
13. Endemic Infections in Developing Countries
14. Indirectly Transmitted Microparasites
PART II: Macroparasites
15. Biology of Host Macroparasite Associations
16. The Basic Model: Statics
17. The Basic Model: Dynamics
18. Acquired Immunity
19. Heterogeneity within the Human Community
20. Indirectly Transmitted Helminths
21. Experimental Epidemiology
22. Parasites, Genetic Variability, and Drug Resistance
23. The Ecology and Genetics of Host-Parasite Associations