88 short papers originating from the 12th International Symposium on Intracranial Pressure and Brain Monitoring held in August 2004 in Hong Kong present experimental as well as clinical research data on invasive and non-invasive intracranial pressure and brain biochemistry monitoring. The papers have undergone a peer-reviewing and are organized in nine sections: ICP management in head injury, neurochemical monitoring, intracranial hypertension, neuroimaging, hydrocephalus, clinical trails, experimental studies, brain compliance and biophysics.
Contents
Wai S. Poon: Preface
A. Marmarou: The Importance of Translational Research in Brain Injury
(Keynote Lecture)
ICP Management in Head Injury
W. S. Poon, S. C. P. Ng, M. T. V. Chan, J. M. K. Lam, W. W. M. Lam:
Cerebral Blood Flow (CBF)-directed Management of Ventilated Head-injured Patients
C. J. Kirkness, R. L. Burr, K. C. Cain, D. W. Newell, P. H. Mitchell:
Relationship of Cerebral Perfusion Pressure Levels to Outcome in Traumatic Brain Injury
L. A. Steiner, M. Balestreri, A. J. Johnston, J. P. Coles, D. A. Chatfield, J. D. Pickard, D. K. Menon, M. Czosnyka:
Effects of Moderate Hyperventilation on Cerebrovascular Pressure-reactivity after Head Injury
I. R. Chambers, P. A. Jones, R. A. Minns, L. Stobbart, A. D. Mendelow, R. C. Tasker, F. Kirkham:
Which Paediatric Head Injured Patients might Benefit from Decompression? Thresholds of ICP and CPP in the First Six Hours
M. Balestreri, M. Czosnyka, L. A. Steiner, M. Hiler, E. A. Schmidt, B. Matta, D. Menon, P. Hutchinson, J. D. Pickard:
Association between Outcome, Cerebral Pressure Reactivity and Slow ICP Waves following Head Injury
P. A. Jones, I. R. Chambers, T. Y. M. Lo, P. J. D. Andrews, W. Chaudhry, A. Clark, J. Croft, R. Forsyth, B. Fulton, A. D. Mendelow, G. Wilson, R. A. Minns:
Quantification of Secondary CPP Insult Severity in Paediatric Head Injured Patients using a Pressure-time Index
P. Nilsson, I. Piper, G. Citerio, I. Chambers, C. Contant, P. Enblad , H. Fiddes, T. Howells, K. Kiening, Y. H. Yau for the BrainIT Group:
The BrainIT Group: Concept and Current Status 2004
J. Barnes, I. Chambers, I. Piper, G. Citerio, C. Contant, P. Enblad, H. Fiddes, T. Howells, K. Kiening, P. Nilsson, Y. H. Yau for the BrainIT Group:
Accurate Data Collection for Head Injury Monitoring Studies: A Data Validation Methodology
P. Smielewski, M. Czosnyka, L. Steiner, M. Belestri, S. Piechnik, J. D. Pickard:
'ICM+': Software for On-line Analysis of Bedside Monitoring Data after Severe Head Trauma
P. Nilsson, P. Enblad, I. Chambers, G. Citerio, H. Fiddes, T. Howells, K. Kiening, A. Ragauskas, J. Sahuquillo, Y. H. Yau, C. Contant, I. Piper for the BrainIT Group:
Survey of Traumatic Brain Injury Management in European Brain-IT Centres Year 2001
U. Meier, A. Gräwe, A. König:
The Importance of Major Extracranial Injuries by the Decompressive Craniectomy in Severe Head Injuries
G. K. Wong, X. L. Zhu, W. S. Poon:
Beneficial Effect of Cerebrolysin on Moderate and Severe Head Injury Patients: Result of a Cohort Study
Neurochemical Monitoring
M. T. V. Chan, S. C. P. Ng, J. M. K. Lam, W. S. Poon, T. Gin:
Re-defining the Ischemic Threshold for Jugular Venous Oxygen Saturation - A Microdialysis Study in Patients with Severe Head Injury
A. Chieregato, M. Marchi, C. Compagnone, V. Albarello, E. Fainardi, F. Tagliaferri, L. Targa:
Estimated Cerebral Respiratory Quotient and Arteriovenous Differences of CO2 in the Ultra Early Detection of Global Ischemia in Severe Head Injury
J. Gasco, J. Sendra, J. Lim, I. Ng:
Linear Correlation between Stable Intracranial Pressure Decrease and Regional Cerebral Oxygenation Improvement following Mannitol Administration in Severe Acute Head Injury Patients
M. Jaeger, M. Soehle, J. Meixensberger:
Brain Tissue Oxygen (PtiO2): A Clinical Comparison of Two Monitoring Devices
R. Kett-White, M. T. O'Connell, P. J. A. Hutchinson, P. G. Al-Rawi, A. K. Gupta, J. D. Pickard, P. J. Kirkpatrick:
Extracellular Amino Acid Changes in Patients during Reversible Cerebral Ischaemia
A. S. Sarrafzadeh, U. -W. Thomale, D. Haux, A. W. Unterberg:
Cerebral Metabolism and Intracranial Hypertension in High Grade Aneurysmal Subarachnoid Haemorrhage Patients
M. T. V Chan, R. Boet, S. C. P. Ng, W. S. Poon, T. Gin:
Effect of Ischemic Preconditioning on Brain Tissue Gases and pH during Temporary Cerebral Artery Occlusion
I. Ng, E. Yap, J. Lim:
Changes in Cerebral Hemodynamics and Cerebral Oxygenation during Surgical Evacuation for Hypertensive Intracerebral Putaminal Hemorrhage
S. Wolf, D. V. Plev, H. A. Trost, Ch. B. Lumenta:
Open Lung Ventilation in Neurosurgery: An Update on Brain Tissue Oxygenation
M. T. V. Chan, R. Boet, S. C. P. Ng, W. S. Poon, T. Gin:
Magnesium Sulfate for Brain Protection during Temporary Cerebral Artery Occlusion
M. T. V. Chan, S. C. P. Ng, J. M. K. Lam, W. S. Poon, T. Gin:
Monitoring of Autoregulation using Intracerebral Microdialysis in Patients with Severe Head Injury
M. Jaeger, M. Soehle, and J. Meixensberger:
Improvement of Brain Tissue Oxygen and Intracranial Pressure During and After Surgical Decompression for Diffuse Brain Oedema and Space Occupying Infarction
Intracranial Hypertension
S. C. Chen, G. Feng:
Clinic Investigation and Logistic Analysis about Risk Factors of Recurrent Hemorrhage after Operation in the Earlier Period of Cerebral Hemorrhage
P. G. Al-Rawi, D. Zygun, M. Y. Tseng, P. J. A. Hutchinson, B. F. Matta, P. J. Kirkpatrick:
Cerebral Blood Flow Augmentation in Patients with Severe Subarachnoid Haemorrhage
N. Alperin, S. H. Lee, M. Mazda, S. G. Hushek, B. Roitberg, J. Goddwin, T. Lichtor:
Evidence for the Importance of Extracranial Venous Flow in Patients with Idiopathic Intracranial Hypertension (IIH)
M. Stilling, E. Karatasi, M. Rasmussen, A. Tankisi, N. Juul, G. E. Cold:
Subdural Intracranial Pressure, Cerebral Perfusion Pressure, and Degree of Cerebral Swelling in Supra- and Infratentorial Space-Occupying Lesions in Children
L. X. Liu, W. W. Dong, J. Wang, Q. Wu, W. He, Y. J. Jia:
The Role of Noninvasive Monitoring of Cerebral Electrical Impedance in Stroke
J. Pachl, P. Haninec, T. Tencer, P. Mizner, L. Houštava, R. Tomáš, P. Waldauf:
The Effect of Subarachnoid Sodium Nitroprusside on the Prevention of Vasospasm in Subarachnoid Haemorrhage
Neuroimaging
A. Marmarou, S. Signoretti, P. Fatouros, G.A. Aygok, R. Bullock:
Mitochondrial Injury Measured by Proton Magnetic Resonance Spectroscopy in Severe Head Trauma Patients
A. Chieregato, F. Tagliaferri, A. Tanfani, F. Cocciolo, W. Benedettini, C. Compagnone, M. Ravaldini, R. Pascarella, R. Battaglia, M. Frattarelli, L. Targa, E. Fainardi:
Cerebral Blood Flow in Mean Cerebral Artery Low Density Areas is not always Ischemic in Patients with Aneurysmal Subarachnoid Hemorrhage-Relationship with Neurological Outcome
A. Chieregato, C. Compagnone, A. Tanfani, M. Ravaldini, F. Tagliaferri, R. Pascarella, F. Servadei, L Targa, E. Fainardi:
Cerebral Blood Flow Mapping in Two Different Subtypes of Intraparenchymal Hemorrhagic Traumatic Lesions
M. T. O'Connell, A. Seal, J. Nortje, P. G. Al-Rawi, J. P. Coles, T. D. Fryer, D. K. Menon, J. D. Pickard, P. J. Hutchinson:
Glucose Metabolism in Traumatic Brain Injury: A Combined Microdialysis and [18F]-2-Fluoro-2-Deoxy-D-Glucose - Positron Emission Tomography (FDG-PET) Study
S. K. Piechnik, L. Hultin:
Postoperative Changes in SPECT-rCBF in Hydrocephalus
Y. L. Chan, D. K. W. Yeung, S. F. Leung, S. F. Lee, A. S. C. Ching:
Dynamic Susceptibility Contrast- Enhanced Perfusion MR Imaging in Late Radiation-induced Injury of the Brain
N. Alperin, S. G. Hushek, S. H. Lee, A. Sivaramakrishnan, T. Lichtor:
MRI Study of Cerebral Blood Flow and CSF flow Dynamics in an Upright Posture: The Effect of Posture on the Intracranial Compliance and Pressure
T. Shiogai, A. Morisaka, N. Takayasu, K. Yoshikawa, T. Mizuno, M. Nakagawa, H. Furuhata:
Quantitative Evaluation of Cerebrovascular Reactivity in Brain Tissue by a Refill Kinetic Method of Transcranial Ultrasonic Perfusion Imaging: A Comparison with Doppler Sonography
N. Alperin, S. H. Lee, A. Sivaramakrishnan, T. Lichtor:
Relationship between Total Cerebral Blood Flow and ICP Measured Noninvasively with Dynamic MRI Technique in Healthy Subjects
Hydrocephalus
S. Shimbles, C. Dodd, K. Banister, A. D. Mendelow, I. R. Chambers:
Clinical Comparison of Tympanic Membrane Displacement with Invasive ICP Measurements
U. Meier:
Gravity Valves for Idiopathic Normal-Pressure Hydrocephalus: A Prospective Study with 60 patients
Z. Czosnyka, F. van den Boogaard, M. Czosnyka, S. Momjian, L. Gelling, J. D. Pickard:
The Relationship between CSF Circulation and Cerebrovascular Pressure-reactivity in Normal Pressure Hydrocephalus
D. Santamarta, J. Martin-Vallejo:
Evolution of Intracranial Pressure during the Immediate Postoperative Period after Endoscopic Third Ventriculostomy
Z. Liu, Y. Y. Dou, R. Chen, X. Z. Zhang:
Clinical Research on Monitoring CSFP through Lumbar Epidural Pressure
Z. H. Czosnyka, M. Czosnyka, H. K. Richards, J. D. Pickard:
Evaluation of Three New Models of Hydrocephalus Shunts
C. Sprung, C. Miethke, H.-G. Schlosser, M. Brock:
The Enigma of Underdrainage in Shunting with Hydrostatic Valves and Possible Solutions
A. Marmarou, P. Black, M. Bergsneider, P. Klinge, N. Relkin, The International NPH Consultant Group:
Guidelines for Management of Idiopathic Normal Pressure Hydrocepalhus: Progress to Date
G. Aygok, A. Marmarou, H. F. Young:
Three-year Outcome of Shunted Idiopathic NPH Patients
Z. Czosnyka, M. Czosnyka, B. Owler, S. Momjian, M. Kasprowicz, E. A. Schmidt, P. Smielewski, J. D. Pickard:
Clinical Testing of CSF Circulation in Hydrocephalus
E. A. Schmidt, Z. Czosnyka, S. Momjian, M. Czosnyka, R. A. Bech, J. D. Pickard:
Intracranial Baroreflex Yielding an Early Cushing Response in Human
U. Meier, S. Mutze:
Does the Ventricle Size Change after Shunt Operation of Normal-pressure Hydrocephalus?
Clinical Trials
R. Boet, M. T. V. Chan, W. S. Poon, G. K. Wong, H. T. Wong, T. Gin:
Intravenous Magnesium Sulfate to Improve Outcome after Aneurysmal Subarachnoid Hemorrhage
Z. Fei, X. Zhang, S. J. Song:
Secondary Insults and Outcomes in Patients with Hypertensive Basal Ganglia Hemorrhage
S. Hayashi, M. Takayasu, S. Inao, J. Yoshida (Nagoya Therapeutic Hypothermia Study Group):
Balance of Risk of Therapeutic Hypothermia
M. Smrcka, M. Vidlák, K. Máca, V. Smrcka, R. Gál:
The Influence of Mild Hypothermia on ICP, CPP and Outcome in Patients with Primary and Secondary Brain Injury
A. Marmarou, A. Saad, G. Aygok, M. Rigsbee:
Contribution of Raised ICP and Hypotension to CPP Reduction in Severe Brain Injury: Correlation to Outcome
J. Lu, A. Marmarou, S. Choi, A. Maas, G. Murray, E.W. Steyerberg, The Impact and Abic Study Group:
Mortality from Traumatic Brain Injury
Brain Compliance
Y. H. Yau, I. R. Piper, C. Contant, L. Dunn, I. R. Whittle for The BrainIT Group:
Assessment of Different Data Representations and Averaging Methods on the Spiegelberg Compliance Device
K. L. Kiening, W. Schoening, A. W. Unterberg, J. F. Stover, G. Citerio, P. Enblad, P. Nilsson and The BrainIT Group:
Assessment of the Relationship between Age and Continuous Intracranial Compliance
S. C. P. Ng, W. S. Poon, M. T. V. Chan:
Cerebral Haemodynamic Assessment in Patients with Thalamic Haemorrhage: A Pilot Study with Continuous Compliance Monitoring
M. Mase, T. Miyati, K. Yamada, H. Kasai, M. Hara, Y. Shibamoto:
Non-invasive Measurement of Intracranial Compliance using Cine MRI in Normal Pressure Hydrocephalus
M. Aboy, J. McNames, W. Wakeland, B. Goldstein:
Pulse and Mean Intracranial Pressure Analysis in Pediatric Traumatic Brain Injury
J. Abdullah, I. Zamzuri, S. Awang, S. Sayuthi, A. Ghani, A. Tahir, N. N. Naing:
Preliminary Report on Spiegelberg Pre- and Post-operative Monitoring of Severe Head-injured Patients who Received Decompressive Craniectomy
K. König, H. E. Heissler, M. Zumkeller, E. Rickels:
Age-dependence of Cerebrospinal Parameters
Biophysics
W. Wakeland, B. Goldstein:
A Computer Model of Intracranial Pressure Dynamics during Traumatic Brain Injury that Explicitly Models Fluid Flows and Volumes
M. L. Daley, C. W. Leffler, M. Czosnyka, J. D. Pickard:
Plateau Waves: Changes of Cerebrovascular Pressure Transmission
A. Peña, J. D. Pickard, D. Stiller, N. G. Harris, M. U. Schuhmann:
Brain Tissue Biomechanics in Cortical Contusion Injury: A Finite Element Analysis
J. Nicolet, T. Gillard, G. Gindre, F. Cervenansky, C. Duale, J. E. Bazin, C. De Riberolles, P. Schoeffler, J. J. Lemaire:
Modifications of Spontaneous Cerebral Blood Flood Oscillations during Cardiopulmonary Bypass
M. Czosnyka, L. Steiner, M. Balestreri, E. Schmidt, P. Smielewski, P. J. Hutchinson, J. D. Pickard:
Concept of "True ICP" in Monitoring and Prognostication in Head Trauma
B. Schmidt, S. F. Bocklisch, M. Päßler, M. Czosnyka, J. J. Schwarze, J. Klingelhöfer:
Fuzzy Pattern Classification of Hemodynamic 6Data can be used to Determine Noninvasive Intracranial Pressure
Y. L. Zhao, J. Y. Zhou, G. H. Zhu:
Clinical Experience with the Noninvasive ICP Monitoring System
A. Ragauskas, G. Daubaris, A. Dziugys, V. Azelis, V. Gedrimas:
Innovative Non-Invasive Method for Absolute Intracranial Pressure Measurement without Calibration
A. Y. S. Cheng, M. C. Y. Pau, W. S. Poon, G. K. C. Wong:
The Correlation of Midline Shifts of Human Brain with Large Brain Haematoma using a Finite Element Approach
A. Ragauskas, G. Daubaris, V. Petkus, V. Ragaisis, M. Ursino:
Clinical Study of Continuous Non-Invasive Cerebrovascular Autoregulation Monitoring in Neurosurgical ICU
Experimental Aspects
C. Woiciechowsky, H.-D. Volk:
Increased Intracranial Pressure Induces a Rapid Systemic Interleukin-10 Release through Activation of the Sympathetic Nervous System
T. Mori, Y. Katayama, J. Kojima, N. Moro, H. Kawai, M. Yoneko, T. Kawamata:
Experimental Model for Investigating Hyponatremia after Subarachnoid Hemorrhage in Rats
G. Wu, F. P. Huang:
Effects of Venom Defibrase on Brain Edema after Intracerebral Hemorrhage in Rats
Y. Gong, G. H. Xi, R. F. Keep, J. T. Hoff, Y. Hua:
Complement Inhibition Attenuates Brain Edema and Neurological Deficits Induced by Thrombin
W. Zhu, Y. Mao, L. F. Zhou:
Reduction of Neural and Vascular Damage by Transplantation of VEGF-secreting Neural Stem Cells after Cerebral Ischemia
R. F. Keep, A. V. Andjelkovic, S. M. Stamatovic, P. Shakui, S. R.Ennis:
Ischemia-induced Endothelial Cell Dysfunction
Y. Hua, L. L. Tang, M. E. Fewel, R. F. Keep, T. Schallert, K. M. Muraszko, J. T. Hoff, G. H. Xi:
Systemic Use of Argatroban Reduces Tumor Mass, Attenuates Neurological Deficits and Prolongs Survival Time in Rat Glioma Models
M. Klarica, R. Varda, M. Vukic, D. Oreškovic, M. Radoš, M. Bulat:
Spinal Contribution to CSF Pressure Lowering Effect of Mannitol in Cats
F. Xiao, S. Pardue, T. Nash, T. C. Arnold, J. S. Alexander, D. L. Carden, R. Turnage, A. Jawahar, S. A. Conrad:
Cell Column Chromatography: A New Research Tool to Quantify Cerebral Cell Volume Changes following Chemically-induced Anoxia/Re-oxygenation
F. Xiao, S. Pardue, T. C. Arnold, J. Monroe, J. S. Alexander, D. L. Carden, R. Turnage, S. A. Conrad:
Ifenprodil Treatment is Associated with a Down-regulation of Brain Aquaporin 4 following Cardiac Arrest in Rats
T. Nakamura, R. F. Keep, Y. Hua, J. W. Park, T. Itano, S. Nagao, J. T. Hoff, G. H. Xi:
Intracerebral Hemorrhage Induces Edema and Oxidative Stress and Alters N-methyl-D-aspartate Receptor Subunits Expression
Y. Gong, G. H. Xi, R. F. Keep, J. T. Hoff, Y. Hua:
Aging Enhances Intracerebral Hemorrhage-induced Brain Injury in Rats
U.-W. Thomale, M. Griebenow, S.-N. Kroppenstedt, A. W. Unterberg, J. F. Stover:
The Antioxidant Effect of N-acethylcysteine on Experimental Contusion in Rats
D. Oreškovic, M. Vukic, M. Klarica, M. Bulat:
The Investigation of Cerebrospinal Fluid Formation by Ventriculo-aqueductal Perfusion Method in Cats
Satellite Symposium: Neurochemical Monitoring
Introduction by Peter Hutchinson and Wai-sang Poon
P. Hutchinson: Microdialysis in TBI: Methodology & Pathophysiology
I. Ng: Brain Tissue Oxygenation Monitoring in Acute Brain Injury
P. Al-Rawi: Near Infra-red Spectroscopy in Brain Injury: Today's Perspective
J. Pickard: Imaging of Cerebral Blood Flow and Metabolism in Brain Injury in the
M. Schuhmann: Brain Injury and Proteomics/Peptidomics: Is it relevant? An Overview
R. Chiu: Circulating Nucleic Acid Analysis: Diagnostic Applications for Acute
C.-H. Nordstrom: The Lund Concept: Is this logical?
Author Index
Index of Keywords