Synopses & Reviews
The rationale for using intraoperative irradiation (IORT) is based on the realization that tolerable doses of eternal beam radiation are often insufficient to achieve control of locally advanced malignancies. In these instances, the IORT component of treatment becomes the optimal conformal technique of irradiation, since dose-limiting organs or structures can either be surgically displaced or protected by placement of lead shielding. This fully revised and expanded second edition is of interest to those with intraoperative electron (IOERT) capabilities, high-dose-rate brachytherapy (HDR-IORT) capabilities, or both. Techniques, indications, and results are discussed by disease site. Each chapter is dual authored by a radiation oncologist and a surgeon, giving a balanced presentation of clinical scenarios. Issues of basic science and physics are also covered, and a notable chapter on normal tissue tolerance is included. Intraoperative Irradiation: Techniques and Results, Second Edition is a superb compilation, providing essential cutting-edge knowledge. It is a foundation for physicians as IORT develops and becomes more widely available.
Synopsis
Fully revised and expanded, Intraoperative Irradiation covers both intraoperative electron (IOERT) capabilities and high-dose-rate brachytherapy (HDR-IORT) capabilities. Techniques, indications, and results are discussed by disease site.
Table of Contents
Part I. General Rationale and Historical Perspective Ch 1 - Rationale and Historical Perspective of Intraoperative Irradiation Leonard L Gunderson, Felipe A Calvo, Christopher G Willett, and Louis B Harrison Ch 2 - Radiobiology of Large Dose per Fraction Irradiation Paul Okunieff, Srinath Sundararaman, Su Metcalfe, and Yuhchyau Chen Part II. Methods and Techniques of Treatment Ch 3 - Intraoperative Electron-Beam Irradiation (IOERT): Physics and Techniques Peter Biggs, Christopher G. Willett, Harm Rutten, Mario Ciocca, Leonard L. Gunderson, and Felipe A. Calvo Ch 4 - HDR-IORT: Physics and Techniques Eli E Furhang, Jussi K Sillanpaa, Kenneth Hu, and Louis B Harrison Ch 5 - Electronic Brachytherapy/Low KV IORT: Physics and Techniques Uta Kraus-Tiefenbacher, Peter Biggs, Jayant Vaidya, and Dario Francescatti Ch 6 - IORT with Electron Beam, High Dose Rate Brachytherapy or Low-KV/Electronic Brachytherapy: Methodological Comparisons Subir Nag, Christopher G. Willett, Leonard L. Gunderson, Louis B. Harrison, Felipe A. Calvo, and Peter Biggs Part III. Normal Tissue Tolerance - IORT Ch 7 - Normal Tissue Tolerance to IOERT, EBRT or Both: Animal Studies and Clinical Zeljko Vujaskovic, Christopher G Willett, Joel E Tepper, Timothy J Kinsella, and Leonard L Gunderson Ch 8 - Central Nervous System Tumors David Ortiz de Urbina, Patrick Schueller, Normann Willich, Kintomo Takakura, Osami Kubo, and Felipe A. Calvo Ch 9 - Head and Neck Cancer Kenneth S. Hu, Sue Yom, Michael J. Kaplan, Louis B. Harrison, and Rafael Martinez-Monge Ch 10 - Breast Cancer Felix Sedlmayer, Jean-Bernard DuBois, Roland Reitsamer, Gerd Fastner, David Olilla, and Roberto Orecchia Ch 11 - Lung CancerJavier Aristu, Felipe A. Calvo, Marta Moreno, Rafael Martínez, Jesús Herreros, Raquel Ciérvide, Jean Bernard Dubois, and Scott Fisher Ch 12 - Gastric Cancer Rafael Martinez-Monge, Miren Gaztañaga, Javier Álvarez-Cienfuegos, Robert C. Miller, and Felipe A. Calvo Ch 13 - Pancreas Cancer Robert C. Miller, Vincenzo Valentini, Adyr Moss, Giuseppe R D'Agostino, Matthew D. Callister, Theodore Hong, Christopher G. Willett, and Leonard L. Gunderson Ch 14 - Bile Duct and Gallbladder Cancer Takeshi Todoroki, Gernot M. Kaiser, Wolfgang Sauerwein, and Leonard L. Gunderson Ch 15 - Primary Colorectal Cancer Nils D. Arvold, Theodore S. Hong, Christopher G. Willett, Paul C. Shellito, Michael G. Haddock, Harm Rutten, Vincenzo Valentini, Brian Czito, and Leonard L. Gunderson Ch 16 - Recurrent Colorectal Cancer Michael G. Haddock, Heidi Nelson, Vincenzo Valentini, Leonard L. Gunderson, Christopher G. Willett, Harm Rutten, Felipe A Calvo, Lou Harrison, Warren Enker, and JL Garcia-Sabrido Ch 17 - Retroperitoneal Sarcomas Brian Czito,