Synopses & Reviews
This volume gives an up-to-date account of the properties of the classes of lipids that are located in the membranes of all cells. These lipids form the essential structural components of the plasma membrane responsible for maintaining the distinct identity of the cell from its surroundings and mediating the flow of vital solutes into and out of the cell. The membrane lipids also represent reservoirs of signaling molecules that modulate a variety of physiological processes. The presentation gives a balanced perspective of what is currently known about the function of these lipids in healthy cells and tissues and what consequences follow malfunctions in their synthesis and metabolism.
Synopsis
This text covers the properties of lipids located in the membranes of all cells. It details current knowledge on the function of these lipids in healthy cells and tissues and what consequences follow malfunctions in their synthesis and metabolism.
Table of Contents
Preface. Contributors. Contributors. Part 1: Fatty Acids. 1. Transcriptional Regulation of Hepatic Fatty Acid Metabolism, Hervé Guillou et al.; 2. Modulation of Protein Function by Isoketals and Levuglandins, Sean S. Davies. 3. Signalling Pathways Controlling Fatty Acid Desaturation, María Cecilia Mansilla et al.; 4. Fatty Acid Hydrolase: A Gate-keeper of the Endocannaboid System, Filomena Fezza et al.; 5. Modulation of Inflammatory Cytokines by Omega-3 Fatty Acids, Jing X. Kang et al.; 6. Eicosenoids in Tumor Progression and Metastasis, Sriram Krishnamoorthy et al.; 7. Fatty Acid Synthase Activity in Tumor Cells, Joy L. Little et al.; Part 2: Phospholipids. 8. Lipids in the Assembly of Membrane Proteins and Organization of Protein Supercomplexes: Implications for Lipid-linked Disorders, Mikhail Bogdanov et at.; 9. Altered Lipid Metabolism in Brain Injury and Disorders, Rao Muralikrishna Adibhatla et al.; 10. Lysophospholipid activation of G-Protein-coupled receptors, Tetsuji Mutoh et al.; 11. Phospholipid-mediated Signaling and Heart Disease, Paramjit S. Tappia et al.; 12. The Role of Phospholipid Oxidation Products in Inflammatory and Autoimmune Diseases. Evidence from Animal Models and in Humans, Norbert Leitinger. 13. Mediation of Apoptosis by Oxidized Phospholipids, Gilbert O. Fruhwirth et al.; Part 3: Sphingolipids. 14. Regulation of Lipid Metabolism by Sphingolipids, Tilla S. Worgall. 15. Multiple Roles for Sphingolipids in Steroid Hormone Biosynthesis, Natasha C. Lucki. 16. Roles of Bioactive Sphingolipids in Cancer Biology and Therapeutics, Sahar A. Saddoughi et al.; 17. Glycosphingolipid Disorders of the Brain, Stephanie D. Boomkamp et al.; 18. Role of Neutral Sphingomyelinases in Aging and Inflammation, Mariana Nikolova-Karakashian et al.; 19. Sphingolipid Metabolizing Enzymes as Novel Therapeutic Targets, Andreas Billich et al.; 20. Ceramide-enriched Membrane Domains in Infectious Biology and Development, Katrin Anne Becker et al.; Part 4: Lipidomics. 21. MALDI-TOF MS Analysis of Lipids from Cells, Tissues and Body Fluids, Beate Fuchs et al.; 22. Lipidomics in Diagnosis of Lipidoses, Claude Wolf and Peter J. Quinn.