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Lungentoxizitat in Vitro

by Matt Florian
Lungentoxizitat in Vitro

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ISBN13: 9783639389500
ISBN10: 3639389506



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Synopses & Reviews

Synopsis

Bei der Etablierung einer In-vitro-Methode zur umfassenden Beurteilung lungentoxischer Wirkungen therapeutischer Aerosole bestehen aufgrund der komplexen Physiologie des humanen Respirationstraktes und den physikochemischen Eigenschaften eines Aerosols zahlreiche Herausforderungen. Die Gas- und Partikelphase eines Aerosols unterliegt einer st ndigen Dynamik. Diese spielt neben anatomischen und atemphysiologischen Faktoren eine wesentliche Rolle, wo und in welcher Dosis sich Aerosolpartikel im Respirationstrakt abscheiden. Ausgehend von dieser Problematik wurde ein auf dem Cultex-Modul basierdes Testsystem entwickelt, das eine qualitative und quantitative Bewertung lungentoxischer Wirkungen therapeutischer Aerosole erm glicht. Da Lungenepithelzellen bei dieser Methode unter Air-Liquid-Bedinungen kultiviert werden, ist apikal eine Direktexposition gegen ber einer Testatmosph re m glich. Dadurch findet eine bessere Reproduktion der In-vivo-Exposition als bei submersen In-vitro-Methoden statt. F r die Evaluierung der Direktexpositionsmehtode wurde ein Vergleich mit konventionellen Methoden zur Untersuchung von Lungentoxizit t durchgef hrt.

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Product Details

ISBN:
9783639389500
Binding:
Trade Paperback
Publication date:
02/29/2012
Publisher:
AV Akademikerverlag
Language:
German
Pages:
124
Height:
.29IN
Width:
6.00IN
Illustration:
Yes
Author:
Matt Florian
Author:
Matt Florian

Ships free on qualified orders.
Add to Cart
$54.95
New Trade Paperback
Available at a Remote Warehouse. Ships separately from other items. Additional shipping charges may apply. Not available for In Store Pickup. More Info
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QtyStore
20Remote Warehouse
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