In addition to movement per se, movement disorders affect multiple mental processes and complex behavioral functions, and so must be taken into careful account when clinically managing a wide variety of behavioral problems. In Mental and Behavioral Dysfunction in Movement Disorders, internationally renowned researchers and clinicians review the many recent developments in the field, both to shed light on and to establish new standards for the study and treatment of the multiple cognitive, affective, and behavioral dysfunctions associated with movement disorders. These dysfunctions include depression, dementia, psychosis, sleep disorders arising from Parkinson's and Huntington's diseases, and Tourette syndrome, as well as multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and many other related disorders. The authors describe these behavioral syndromes and their neurophysiological and neuropathological substratum, as well as their diagnostic criteria and therapeutic guidelines. For each syndrome, the cognitive deficits of attention, memory, language, praxis, and executive functions are spelled out in detail. Also discussed are the neuropsychiatry of movement disorders and the quality of life issues associated with Parkinson's disease. Exhaustive and cutting-edge, Mental and Behavioral Dysfunction in Movement Disorders illuminates the many complex mental and behavioral conditions associated with these disorders, and constitutes an essential guide for all physicians treating these problems or scientists studying these topics today.
"An impressive, diverse range of basic science and clinical topics are covered, at least some of which are certain to appeal to every reader...this book has much to offer researchers in this subject." -The Lancet
I. Introduction
Historical Issues in the Study of Behavioral Dysfunction in Movement Disorders
Christopher G. Goetz
II. Mental Processing in the Motor Structures of the Brain
Fundamental and Clinical Evidence for Basal Ganglia Influences on Cognition
Frank A. Middleton
Integrating Cognition and Motivation into the Basal Ganglia Pathways of Action
Suzanne N. Haber
Understanding Corticobasal Ganglia Networks as Part of a Habit Formation System
Ann M. Graybiel and Yasuo Kubota
The Role of the Cerebellum in Cognition and Emotion
Jeremy D. Schmahmann
III. Cognition in Movement Disorders
Assessing Cognition in Movement Disorders
Julie C. Stout and Jane S. Paulsen
Disorders of Intention in Parkinsonian Syndromes
Richard G. Brown
Cognitive Control in Frontostriatal Disorders
Francois Richer and Sylvain Chouinard
Disorders of Speech and Language in Parkinson's Disease
Henri Cohen
Distinctive Features of Apraxia in Corticobasal Degeneration and Other Neurological Illnesses
Ramón Leiguarda
Neuropsychological Deficits in Cerebellar Syndromes
Hermann Ackermann and Irene Daum
IV. Neurophysiology of Cognition in Movement Disorders
Induction and Reversal of Cognitive Deficits in a Primate Model of Huntington's Disease
Stéphane Palfi, Emmanuel Brouillet, Françoise Condé, and Philippe Hantraye
Induction and Reversal of Cognitive Deficits in a Primate Model of Parkinson's Disease
Jay S. Schneider
Catecholamines and Cognition: Bridging the Gap Between Animal Studies and Clinical Syndromes
Trevor W. Robbins, Harriet S. Crofts, Roshan Cools, and Angela C. Roberts
Nondopaminergic Influences on Cognition in Parkinson's Disease
Marc-André Bédard, Maxime Lévesque, Simon Lemay, and François Paquet
Cognitive Consequences of Neurosurgery for Parkinson's Disease
Jean A. Saint-Cyr
V. Dementia in Movement Disorders
The Clinical Spectrum of Dementia in Movement Disorders: An Overview
Andrew Kertesz
Neuropathological Distinctions and Similarities in Movement Disorders with Dementia
Kurt A. Jellinger
Homologies Between the Genetic Etiology and Pathogenesis of the Synucleinopathies and Tauopathies
John Hardy
Prevalence, Incidence, and Risk Factors for Dementia in Parkinson's Disease
Gilberto Levy and Karen Marder
Neuropsychiatric Co-Morbidity in Dementia With and Without Movement Disorders
Clive G. Ballard and Alan Thomas.
Neurotransmitter Correlates of Neuropsychiatric Symptoms in Dementia with Lewy Bodies
Elaine K. Perry, Margaret A. Piggott, Mary Johnson, Clive G. Ballard, Ian G. McKeith, Robert Perry, and David Burn
Acetylcholinesterase Inhibitors in the Treatment of Dementia in Parkinson's Disease
Amos D. Korczyn and Nir Giladi
VI. Neuropsychiatric Aspects of Movement Disorders
Mood Disorders and the Globus Pallidus
Edward C. Lauterbach
Cortical-Limbic-Striatal Dysfunction in Depression: Converging Findings in Basal Ganglia Diseases and Primary Affective Disorders
Taresa L. Stefurak and Helen S. Mayberg
Agitation and Apathy in Hyper- and Hypokinetic Movement Disorders
Irene Litvan and Jaime Kulisevsky
Diagnosis and Treatment of Depression in Parkinson's Disease
Vladimir S. Kosti´c, Elka Stefanova, Nataþsa Dragaþsevi´c, and Saþska Potrebi´c
Diagnosis and Treatment of Hallucinations and Delusions in Parkinson's Disease
Dag Aarsland and Jan Petter Larsen
REM Sleep Behavior Disorder in Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy
Bradley F. Boeve, Michael H. Silber, Tanis J. Ferman, Joseph E. Parisi, Dennis W. Dickson, Glenn E. Smith, John Lucas, and Ronald C. Petersen
Psychogenic Parkinsonism and Dystonia
Daniel S. Sa and Anthony E. Lang
Clinical Management of Psychosis and Mood Disorders in Huntington's Disease
Mark Guttman, Meneske Alpay, Sylvain Chouinard, Peter Como, Anthony Feinstein, Ira Leroi, and Adam Rosenblatt
Clinical Management of Aggression and Frontal Symptoms in Huntington's Disease
Adam Rosenblatt, Karen Anderson, Alex D. Goumeniouk, Paul Lespérance, Martha A. Nance, Jane S. Paulsen, Allen Rubin, Jean A. Saint-Cyr, Russ Sethna, and Mark Guttman
Heterogeneous Psychopathology of Tourette Syndrome
Mary M. Robertson
In Search of the Pathophysiology of Tourette Syndrome
James F. Leckman
Obsessive-Compulsive Disorder as a Frontostriatal-Thalamic Dysfunction
Tiffany R. Farchione, Shauna N. MacMillan, and David R. Rosenberg
Dyskinesia in Patients with Schizophrenia Never Treated with Antipsychotics: Conceptual and Pathophysiological Implications
Christian Bocti, Deborah N. Black, and John L. Waddington
VII. Quality of Life in Parkinson's Disease
Medical and Psychosocial Determinants of Quality of Life in Parkinson's Disease
Anette Schrag and Caroline Selai
Sexuality and Parkinson's Disease
Gila Bronner, Vladimir Royter, Amos D. Korczyn, and Nir Giladi
Daytime Sleepiness and Sleep Attacks in Idiopathic Parkinson's Disease
David B. Rye, Joseph T. Daley, Amanda A. Freeman, and Donald L. Bliwise
Natural Evolution and Life Expectancy in Parkinson's Disease
Werner Poewe
Index