Synopses & Reviews
This book provides an approach to discussing new targets for molecular strategies in heart failure therapy. On the basis of most recent data, international experts in this field elaborate on the most relevant pathophysiological alterations in heart failure on a molecular level and discuss potential strategies. These include technical aspects of gene transfer, gene transfer approaches to treating pump failure and arrhythmias, and gene transfer to prevent apoptosis. Furthermore, the topics myocyte transplantation and cell cycle regulation are discussed.
The book contains twenty-one chapters including state-of-the-art review articles as well as original papers.
Synopsis
Alterations in excitation-contraction coupling and potential gene thrapy targets in failing human hearts.- Cardiac overexpression of -adrenergic receptors.- Genetic approaches to elucidate the regulatory role of phospholamban in the heart-. Manipulation of SERCA2a in the heart by gene transfer-. Changing the cardiac calcium transient: SERCA2 overexpression versus phospholamban inhibition.- Adenovirus-mediated gene transfer of SERCA isoforms.- Overexpression of FKBP12.6 to influenxe SR function.- Adenovirus-mediated myocardial gene therapy.- Adenovirus-mediated transfection of multicellular cardiac preparations.- Myocardial-specific gene delivery.- Transfection studies using a new cardiac 3D gel system.- Cellular mechanisms of cardiac arrhythmias - do they play a role in heart failure?.- Potassium channel overexpression.- Mechanisms and relevance of apoptosis.- Strategies to prevent apoptosis.- Neurohumoral modulation of metalloproeinases in cardiac failure: impact on remodeling.- Oxidative stress in heart failure.- Modulation of cardiac function by essential myosin light chains in health and disease.- Mycardial infarction, infarct repair, and strategies for muscle regeneration.- Cardiomyocytes can induce rhythmic contraction of skeletal muscle cells. Potenial use for infarct repair.- Strategies to identify cardimyocyte xell cycle regulatory genes.
Table of Contents
1. Alterations in excitation-contraction coupling and potential gene therapy targets in failing human hearts / B. Pieske -- 2. Cardiac overexpression of gbs-adrenergic receptors / M.J. Lohse, S. Engelhardt -- 3. Genetic approaches to elucidate the regulatory role of phospholamban in the heart / A.G. Schmidt, E.G. Kranias -- 4. Manipulation of SERCA2a in the heart by gene transfer / F. del Monte, S.E. Harding, R.J. Hajjar -- 5. Changing the cardiac calcium transient: SERCA2 overexpression versus phospholamban inhibition / W.H. Dillmann -- 6. Adenovirus-mediated gene transfer of SERCA isoforms / G. Inesi ... et al. -- 7. Overexpression of FKBP12.6 to influence SR function /J. Prestle ... et al. -- 8. Adenovirus-mediated myocardial gene therapy / J.K. Donahue -- 9. Adenovirus-mediated transfection of multicellular cardiac preparations / P.M.L. Janssen ... et al. -- 10. Myocardial-specific gene delivery / W.-M. Franz ... et al. -- 11. Transfection studies using a new cardiac 3D gel system / T. Eschenhagen ... et al. -- 12. Cellular mechanisms of cardiac arrhythmias -do they play a role in heart failure? / D.J. Beuckelmann, L. Priebe, U.C. Hoppe -- 13. Potassium channel overexpression / U.C. Hoppe ... et al. -- 14. Mechanisms and relevance of apoptosis / J. Holtz, M. Tostlebe, D. Darmer -- 15. Strategies to prevent apoptosis / A. Haunstetter, S. Izumo -- 16. Neurohumoral modulation of metalloproteinases in cardiac failure: impact on remodeling / D.A. Kass, H. Senzaki, N. Paolocci -- 17. Oxidative stress in heart failure / D.B. Sawyer, W.S. Colucci -- 18. Modulation of cardiac function by essential myosin light chains in health and disease / I. Morano -- 19. Myocardial infraction, infarct repair, and strategies for muscle regeneration / C.E. Murry, M. Zhang, H. Reinecke -- 20. Cardiomyocytes can induce rhythmic contraction of skeletal muscle cells. Potential use infarct repair / H. Reinecke ... et al. -- 21. Strategies to indentify cardiomyocyte cells cycle regulatory genes / K.B.S. Pasumarthi, L.J. Field.