Synopses & Reviews
The field of immunology has progressed so much since the first edition of this book was published seven years ago, that this fully updated second edition appears as a major new work. Its wide scope, depth of coverage, and eminence of authorship make it unique in the field. Like other volumes in the Frontiers in Molecular Biology series, this book presents an up-to-date picture of current research topics in a key area. The contributors to this book have been carefully chosen to reflect the main thrusts of research efforts across a broad range within the rapidly developing field of immunology. Subjects covered include immunoglobulin gene rearrangement, the MHC antigens, B-cell activation, and the complement system. The book is well-illustrated, and there are over 1900 references cited.
Review
"Its chapters are written by leading experts, and the information is presented in a comprehensive yet direct manner. The most striking feature of the book is the number of references cited. Close to 2,000 publications, all with complete titles and authors, are referred to. . . . On the whole, presentations are even and well thought out."--Quarterly Review of Biology
"An excellent second edition on important topics in molecular immunology. It covers in detail the generation and application of engineered antibodies and the molecular mechanisms of antigen presentation; immunoglobulin and T cell receptor rearrangements and expression; and the activation of B cells, T cells, and the complement cascade. The book incorporates contributions from recognized experts, most of whom work for academic research institutions in the U.S....Excellent and comprehensive."--Doody's Health Sciences Book Review
Listed in "Books of Interest" in Journal of Medicinal Chemistry
Synopsis
Research progress on the molecular biology of the immune system has been particularly rapid. This unique volume brings together five reviews by leading researchers on all major aspects of work in this area. These exciting advances have major implications not only for immunologists, but for all researchers studying gene structure and function.
Table of Contents
1. Mechanism and control of immunoglobulin gene rearrangement,
Rusty Lansford, Ami Okada, Jianzhu Chen, Eugene M. Oltz, T. Keith Blackwell, Frederick W. Alt, and Gary Rathbun2. T cell antigen recepotor genes, Mark M. Davis and Yueh-hsui Chien
3. T lymphocyte signal transduction, Cox Terhorst, Mark Exley, Frank Staal and Hergen Spits
4. Structure and function of MHC class I and class II antigens, David Jewell and Ian A. Wilson
5. Molecular mechanisms of antigen processing, John J. Monaco
6. B cell activation, Gerry G.B. Klaus
7. Advances in antibody engineering, Martine E. Verhoeyen and John H.C. Windust
8. The complement system, Kenneth B.M. Reid