Synopses & Reviews
Investigations involving incisive mechanistic dissection of various types of synaptic plasticity have revealed that it plays key roles in neural development, sensory information processing, cortical remapping following brain injury, perception, and behavioral learning and memory. Disruptions of synaptic plasticity may underlie neurological and behavioral disorders such as Alzheimer disease, Fragile-X syndrome,
Synopsis
This book highlights methods for probing the cellular and molecular mechanisms of synaptic plasticity in the nervous systems of vertebrate and invertebrate species. Includes strategies for studying plasticity, neural development and synaptogenesis and more.
Table of Contents
Part I: Biochemical and Genetic Strategies for Probing Synaptic Plasticity and Behavior 1. Conditional Gene Targeting: A Refined Method for Genetic Studies in Neurosciences Jane Beil, Isabelle M. Mansuy, and Thorsten Buch 2. Sindbis Virus-Mediated In Vivo Expression of Recombinant CREB to Study Gene Function in Neuronal Plasticity and Behavior Hélène Marie 3. Exploring Mechanisms of Synaptic Plasticity Using Exogenous Expression of Proteins at the Sensory-to-Motor Neuron Synapse of Aplysia Daniel B. Weatherill, Tyler W. Dunn, Patrick K. McCamphill, and Wayne S. Sossin 4. Translational Regulation of Synaptic Plasticity Emanuela Santini, Eric Klann, and Charles Hoeffer Part II: Synaptic Development and Neurogenesis 5. Glutamate Receptors and Synaptic Physiology in Developing Neural Circuits Declan W. Ali, Marcus E. Cunningham, and Birbickram Roy 6. Laminar Quantification of Dendrites in Dentate Gyrus Granule Neurons Shira Rosenzweig and J. Martin Wojtowicz Part III: Electrophysiological and Optical Interrogation of Synaptic Physiology in Brain Slices and Dissociated Cell Preparations 7. Electrophysiological and Biochemical Studies of AMPA Receptor Phosphorylation and Synaptic Plasticity in Hippocampal CA1 Mini-Slices Erin E. Gray and Thomas J. O'Dell 8. Electrophysiological and Behavioral Approaches to the Analysis of Synaptic Tagging and Capture Roger Redondo and Richard G.M. Morris 9. Intracellular Loading and Rapid Calcium Imaging in Processes of Hippocampal Astrocytes Aude Panatier and Richard Robitaille 10. Electrophysiological Methods for Investigating Inhibitory Synaptic Plasticity Melanie A. Woodin 11. Converging Methodologies in a Mammalian 'Simple System' Focused on the Biology of Memory: Conditioned Odor Preference in the Neonate Rat Qi Yuan, Carolyn W. Harley, and John H. McLean 12. The Sagittally-Sectioned Rat Hindbrain Preparation: Improved Access to the Brainstem Respiratory Network Nicholas M. Mellen and Gregory D. Funk