Synopses & Reviews
Integrating the many recent advances from DNA technology, Maarten Reith and his contributors fully update all the material in his highly acclaimed first edition, expanding it to include the important progress made in characterizing the structure, function, regulation, and physiological relevance of each transporter. The new material includes discussions of gene organization and the relationship of polymorphisms of monoamine transporters with a variety of diseases, transgenic animals carrying altered genes for plasma membrane monoamine transporters, and the regulation of transporters by trafficking in relation to their phosphorylation state. Also addressed are transporter imaging techniques that allow in vivo measurement in men and animals, chimera and site-directed mutagenesis studies, and transporter electrophysiology. Many chapters will be of interest to physicians carrying out imaging and postmortem measurements of neurotransmitter transporters in the human brain, and to physicians who study the relation of gene linkages and polymorphisms to psychiatric and other complex human diseases. Complete and up-to-date, Neurotransmitter Transporters: Structure, Function, and Regulation, Second Edition continues to be the most informative and useful review of this most active field, allowing comparison between the characteristics of various neurotransmitter transporters and their biological roles in such a way that progress for one transporter can help move work on another transporter forward.
Review
From Reviews of the first edition... "...highly informative and useful..."-Trends in Neurosciences
Review
From Reviews of the first edition...
"...highly informative and useful..."-Trends in Neurosciences
Synopsis
Maarten Reith and his contributors fully update all the material in his widely acclaimed first edition, expanding it to include the important progress made in characterizing the structure, function, regulation, and physiological relevance of each transporter. The new material includes discussions of gene organization and the relationship of polymorphisms of monoamine transporters with a variety of diseases, transgenic animals carrying altered genes for plasma membrane monoamine transporters, and the regulation of transporters by trafficking in relation to their phosphorylation state. Also addressed are transporter imaging techniques that allow in vivo measurement in men and animals, chimera and site-directed mutagenesis of transporters, and transporter electrophysiology. Neurotransmitter Transporters: Structure, Function, and Regulation, Second Edition continues to be the most informative and useful review of the field, allowing comparison between the characteristics of various neurotransmitter transporters and their biological roles in such a way that progress for one transporter can help move the field of another transporter forward.
Table of Contents
Regulation of Monoamine Transporters: Regulated Phosphorylation, Dephosphorylation, and Trafficking Sammanda Ramamoorthy Mechanisms of Biogenic Amine Neurotransmitter Transporters Gary Rudnick Structure-Function Relationships for Biogenic Amine Neurotransmitter Transporters Nian-Hang Chen and Maarten E. A. Reith Gene Organization and Polymorphisms of Monoamine Transporters: Relationship to Psychiatric and Other Complex Diseases Maureen K. Hahn and Randy D. Blakely Monoamine Transporters: Their Role in Maintaining Neuronal Homeostasis Raul R. Gainetdinov and Marc G. Caron Family of Sodium-Coupled Transporters for GABA, Glycine, Proline, Betaine, Taurine, and Creatine: Pharmacology, Physiology, and Regulation Scott L. Deken, Robert T. Fremeau, Jr., and Michael W. Quick Sodium-Coupled GABA and Glutamate Transporters: Structure and Function Baruch I. Kanner The High-Affinity Glutamate and Neutral Amino-Acid Transporter Family: Structure, Function, and Physiological Relevance Yoshikatsu Kanai, Davide Trotti, Urs V. Berger, and Matthias A. Hediger Vesicular Neurotransmitter Transporters: Pharmacology, Biochemistry, and Molecular Analysis\ Rodrigo Yelin and Shimon Schuldiner Neurotransmitter-Transporter Proteins: Post-Translational Modifications Amrat P. Patel and Maarten E. A. Reith Dopamine-Transporter Uptake Blockers: Structure-Activity Relationships F. Ivy Carroll, Anita H. Lewin, and S. Wayne Mascarella Imaging the Brain Dopamine Transporter Using PET and SPECT S. John Gatley, Nora D. Volkow, Joanna S. Fowler, Yu-Shin Ding, Jean Logan, Gene-Jack Wang, Christoph Felder, Frank W. Telang, and Andrew N. Gifford In Vitro and In Vivo Imaging of the Human Dopamine Transporter in Cocaine Abusers Deborah C. Mash and Julie K. Staley Index