Synopses & Reviews
This timely book defines the role and scope of nuclear medicine imaging techniques (gamma scintigraphy) in pharmaceutical research, providing a wealth of information from clinical trial data.
The nine chapters cover all aspects of using this technique, ranging from regulatory requirements and ethical submission through to approval for study in normal human subjects and patient groups. It also provides detailed descriptions of the scintigraphic study off: drug delivery to the respiratory tract and nasal cavity; esophageal transit and retention; oral drug delivery and GI absorption; colonic release and absorption ocular drug delivery; drug carriers and conjugates; and PET in pharmaceutical research.
Synopsis
This text defines the role and scope of nuclear medicine imaging techniques (gamma scintigraphy) in pharmaceutical research, giving information from clinical trial data.
Synopsis
Radioactive tracers are playing an increasingly important role in the study of drug formulation and drug delivery systems, ranging from the discovery of new drugs to the in vivo evaluation of drug delivery in humans. This text defines the role and scope of nuclear medicine imaging techniques (gamma scintigraphy) in pharmaceutical research, giving information from clinical trial data. As the editors state, no other technique can localise so precisely the site of disintegration of a tablet in the gastro intestinal tract, the penetration of an aerosol in the lung or the residence time of a drug on the cornea. There are 10 chapters covering all aspects of scintigraphic imaging applied to pharmaceutical research, ranging from the regulatory requirements, ethical submission and study approval in normal human subjects and patients groups, through to detailed descriptions of specific applications. The introductory chapters provide descriptions of the basic instrumentation, techniques, the principles of GMP applied to radiolabelling procedures and the importance of validation of products and procedures.