Synopses & Reviews
Paul Ehrlich's Receptor Immunology: The Magnificent Obsession comprises a comprehensive history and exciting analysis of the work of Paul Ehrlich, MD (1854-1915), one of the founding fathers of immunology. A clinician by training, his research marked him as a pioneer experimentalist in hematology, immunology, and chemotherapy. A 1908 Nobel Prize Laureate for Physiology or Medicine, he also discovered a cure for syphilis (Salvarsan) and propounded the side-chain theory in immunology. As a result of his work, he laid the groundwork for the first 50 years of immunology, including the selectionist theory of antibody formation, kinetics of primary and secondary antibody response, quantitative methods of measurement of antigens and antibody, and demonstration of passive transfer of immunity from mother to fetus.
A significant contribution to the Ehrlich legacy that has shaped our current world, this work is an invaluable resource for immunologists, virologists, geneticists, molecular biologists, hematologists, and science historians.
Key Features
· the selectionist theory of antibody formation
· kinetics of primary and secondary antibody response
· quantitative methods of measurement of antigens and antibody
· demonstration of passive transfer of immunity from mother to fetus
About the Author
Dr. Arthur M. Silverstein is one of the foremost historians of immunology, who's earlier wrok, History of Immunology (1989) is the most significant immunology resource of its kind. A Professor Emeritus of Johns Hopkins University, he continues his work in history of science, medicine, and technology.
Review
"...it gives a rich and detailed overview of the intellectual development of Ehrlich's immunology"-MEDICAL HISTORY (April 2003)
Synopsis
Paul Ehrlich's Receptor Immunology: The Magnificent Obsession describes the background to Paul Ehrlich's immunological works and theories and delves into the substance of his experiments in great detail. By exploring these early developments in immunology, the book lays the foundation for modern concepts, providing immunologists, biomedical researchers, and students the context for the discoveries in their field.
- The selectionist theory of antibody formation
- Kinetics of primary and secondary antibody response
- Quantitative methods of measurement of antigens and antibody
- Demonstration of passive transfer of immunity from mother to foetus
Synopsis
ists, and science historians.
Key Features
· the selectionist theory of antibody formation
· kinetics of primary and secondary antibody response
· quantitative methods of measurement of antigens and antibody
· demonstration of passive transfer of immunity from mother to fetus
About the Author
Dr. Arthur M. Silverstein is one of the foremost historians of immunology, who's earlier wrok, History of Immunology (1989) is the most significant immunology resource of its kind. A Professor Emeritus of Johns Hopkins University, he continues his work in history of science, medicine, and technology.
Synopsis
A comprehensive and fascinating history of one of the founding fathers of immunology
Synopsis
This book describes the background to Paul Ehrlich's immunological works and theories and delves into the substance of his experiments in great detail. By exploring these early developments in immunology, the book lays the foundation for modern concepts, providing immunologists, biomedical researchers, and students the context for the discoveries in their field.
the selectionist theory of antibody formation
kinetics of primary and secondary antibody response
quantitative methods of measurement of antigens and antibody
demonstration of passive transfer of immunity from mother to foetus
Synopsis
This book describes the background to Paul Ehrlich's immunological works and theories and delves into the substance of his experiments in great detail. By exploring these early developments in immunology, the book lays the foundation for modern concepts, providing immunologists, biomedical researchers, and students the context for the discoveries in their field.
the selectionist theory of antibody formation
kinetics of primary and secondary antibody response
quantitative methods of measurement of antigens and antibody
demonstration of passive transfer of immunity from mother to foetus
Synopsis
ists, and science historians.
Key Features
· the selectionist theory of antibody formation
· kinetics of primary and secondary antibody response
· quantitative methods of measurement of antigens and antibody
· demonstration of passive transfer of immunity from mother to fetus
About the Author
Dr. Arthur M. Silverstein is one of the foremost historians of immunology, who's earlier wrok, History of Immunology (1989) is the most significant immunology resource of its kind. A Professor Emeritus of Johns Hopkins University, he continues his work in history of science, medicine, and technology.
Synopsis
s University, he continues his work in history of science, medicine, and technology.
Synopsis
nd. A Professor Emeritus of Johns Hopkins University, he continues his work in history of science, medicine, and technology.
Synopsis
ransfer of immunity from mother to fetus
About the Author
Dr. Arthur M. Silverstein is one of the foremost historians of immunology, who's earlier wrok, History of Immunology (1989) is the most significant immunology resource of its kind. A Professor Emeritus of Johns Hopkins University, he continues his work in history of science, medicine, and technology.
Table of Contents
List of Plates.
Introduction by Sir Gustav Nossal.
Preface.
The Background to Ehrlich's Immunology: Origins of the Receptor Theory.
On Ricin and Abrin: Quantitation Enters Immunity Research.
The Value of Mother's Milk: The Founding of Pediatric Immunology.
The Standardization of Toxins and Antitoxins.
The Toxin-Antitoxin Reaction: Theory Outpaces Data.
The Side-Chain Theory of Antibody Formation.
Immune Hemolysis: Bordet Challenges Ehrlich.
New Scientific Challenges.
Ehrlich's Scientific Style.
Appendix A. Paul Ehrlich's Honors.
Appendix B. Paul Ehrlich's Scientific Bibliography.
Name Index.
Subject Index.