Synopses & Reviews
In
Peptide Modifications to Increase Metabolic Stability and Activity, expert researchers in the field provide summarized methods for preparation, purification of modified peptides, and assessment of their biochemical activities. These methods and protocols include preparation of conformationally constrained peptides, modification of peptide bonds, introduction of nonproteinogenic amino acids, and alteration of peptides' physical and biological properties by modification of the amino acid side chains and/or terminal residues. With additional chapter that describes new experimental approach for the detection of exogenous peptides within living cells using peptides labeled with heavy isotopes and confocal Raman microscopy. Written in the highly successful
Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Peptide Modifications to Increase Metabolic Stability and Activity seeks to provide scientists with alternative approaches to peptide modification that many researchers may find applicable to their specific research requirements.
Synopsis
In Peptide Modifications to Increase Metabolic Stability and Activity, expert researchers in the field provide summarized methods for preparation, purification of modified peptides, and assessment of their biochemical activities. These methods and protocols include preparation of conformationally constrained peptides, modification of peptide bonds, introduction of nonproteinogenic amino acids, and alteration of peptides' physical and biological properties by modification of the amino acid side chains and/or terminal residues. With additional chapter that describes new experimental approach for the detection of exogenous peptides within living cells using peptides labeled with heavy isotopes and confocal Raman microscopy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Peptide Modifications to Increase Metabolic Stability and Activity seeks to provide scientists with alternative approaches to peptide modification that many researchers may find applicable to their specific research requirements.
Synopsis
This book provides summarized methods for the preparation, purification of modified peptides, and assessment of their biochemical activities. It features step-by-step detail essential for reproducible results and expert implementation advice.
Table of Contents
1. Hantzsch Based Macrocyclization Approach for the Synthesis of Thiazole Containing Cyclopeptides Adel Nefzi 2. The Chemical Synthesis of α-Conotoxins and Structurally Modified Analogs with Enhanced Biological Stability Jayati Banerjee, Reena Gyanda, Yi-Pin Chang, and Christopher J. Armishaw 3. Synthesis of AApeptides Youhong Niu, Yaogang Hu, Haifan Wu, and Jianfeng Cai 4. Peptoids and Peptide - Peptoid Hybrid Biopolymers as Peptidomimetics Maciej J. Stawikowski 5. Synthesis of Side Chain N,N′-diaminoalkylated Derivatives of Basic Amino Acids for Application in Solid-phase Peptide Synthesis Jean-Philippe Pitteloud, Nina Bionda, and Predrag Cudic 6. Study Protein Folding and Aggregation Using Non-natural Amino Acid p-cyanophenylalanine as a Sensitive Optical Probe Deguo Du, Haiyang Liu, and Bimlesh Ojha 7. AdamantoyLated Biologically Active Small Peptides and Glycopeptides Structurally Related to the Bacterial Peptidoglycan Ruža Frkanec, Branka Vranešić, and Srdjanka Tomić 8. Optimization of Physicochemical and Pharmacological Properties of Peptide Drugs by Glycosylation Maria C. Rodriguez and Mare Cudic 9. The Maillard Reaction Induced Modification of Endogenous Opioid Peptide Encephalin Andreja Jakas 10. Solid-phase Guanidinylation of Peptidyl Amines Compatible with Standard Fmoc-chemistry: Formation of Monosubstituted Guanidines Nina Bionda and Predrag Cudic 11. Stabilization of Collagen-Model, Triple-Helical Peptides for In Vitro and In Vivo Applications Manishabrata Bhowmick and Gregg B. Fields 12. Identification of Adipokine Receptor Agonists and Turning Them to Antagonists Laszlo Otvos, Jr. 13. Peptide Detection and Structure Determination in Live Cells using Confocal Raman Microscopy Andrew C. Terentis and Jing Ye