Synopses & Reviews
Synopsis
This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. Persisters play a leading role in the recalcitrance of chronic infections, and enable the development of classical antibiotic resistance. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level.
Synopsis
Chapter 1: Evolution under antibiotic treatments: interplay between antibiotic persistence, tolerance and resistance Nathalie Q. Balaban and Jiafeng Liu
Chapter 2: Antibiotic persisters and relapsing Salmonella enterica infectionsPeter W. S. Hill and Sophie Helaine
Chapter 3: The Biology of Persister Cells in E. coliAlexander Harms
Chapter 4: Persister Formation and Antibiotic Tolerance of Chronic InfectionsKim Lewis and Sylvie Manuse
Chapter 5: Persister formation driven by TisB-dependent membrane depolarizationBork A. Berghoff and E. Gerhart H. Wagner
Chapter 6: Toxin-antitoxin systems and persistenceNathan Fraikin, Fr d ric Goormaghtigh and Laurence Van Melderen
Chapter 7: Nutrient depletion and bacterial persistence. Wendy W. K. Mok and Mark P. Brynildsen Chapter 8: Genetic determinants of persistence in Escherichia coliDorien Wilmaerts, Pauline Herpels, Jan Michiels, Natalie Verstraeten
Chapter 9: Persister resuscitationArvi J ers, Marta Putrins, Niilo Kaldalu, Hannes Luidalepp, Tanel Tenson
Chapter 10: Host-pathogen interactions influencing Mycobacterium tuberculosis persistence and drug tolerance Huiqing Zheng and Robert B. Abramovitch
Chapter 11: Drug susceptibility of individual mycobacterial cellsMaikel Boot & Hesper Rego
Chapter 12: Antimicrobial drug discovery against persistersWooseong Kim, Iliana Escobar, Beth Burgwyn Fuchs, and Eleftherios Mylonakis