Synopses & Reviews
Completely updated and revised in a new edition, Principles of Development presents major principles and concepts in the field for an undergraduate audience. Emphasizing gene control as the key to understanding development, the third edition is written in accessible prose, utilizing an impressive art program - 650 full color figures - as well as summaries and diagrams throughout the text to illuminate conceptually challenging material. In addition, the third edition presents carefully selected articles for further reading that expound on principles covered in the text.
Synopsis
Completely updated and revised in a new edition, Principles of Development presents major principles and concepts in the field for an undergraduate audience. Emphasizing gene control as the key to understanding development, the third edition is written in accessible prose, utilizing an impressive art program - 650 full color figures - as well as summaries and diagrams throughout the text to illuminate conceptually challenging material. In addition, the third edition presents carefully selected articles for further reading that expound on principles covered in the text.
About the Author
Lewis Wolpert, Department of Biochemistry and Molecular Biology, University College London
Jim Smith, Cancer Research UK Gurdon Institute, Cambridge
Tom Jessell, Department of Biochemistry and Molecular Biophysics, University of Columbia, New York Peter Lawrence, MRC Laboratory of Molecular Biology, Cambridge Elizabeth Robertson, The Wellcome Trust Centre for Human Genetics, Oxford
Elliot Meyerowitz, California Institute of Technology
Table of Contents
Chapter 1. History and Basic Concepts
The Origins of Developmental Biology
A Conceptual Tool Kit
Chapter 2. Model Systems
Model Organisms: Vertebrates
Model Organisms: Invertebrates
Model Systems: Plants
Identifying Developmental Genes
Chapter 3. Patterning the Vertebrate Body Plan I: Axes and Germ Layers
Setting Up the Body Axes
The Origin and Specification of the Germ Layers
Chapter 4. Patterning the Vertebrate Body Plan II: The Mesoderm and Early Nervous System
Somite Formation and Patterning
Neural Induction and the Role of the Organizer
Chapter 5. Development of the Drosophila Body Plan
Maternal Genes Set Up the Body Axes
Polarization of the Body Axes During Oogenesis
Zygotic Genes Pattern the Early Embryo
Segmentation: Activation of the Pair-Rule Genes
Segment Polarity Genes and Compartments
Segmentation: Selector and Homeotic Genes
Chapter 6. Development of Invertebrates, Ascidians, and Slime Molds
Nematodes
Echinoderms
Ascidians
Cellular Slime Molds
Chapter 7. Plant Development
Embryonic Development
Meristems
Flower Development
Chapter 8. Morphogenesis: Change in Form in the Early Embryo
Cell Adhesion
Cleavage and Formation of the Blastula
Gastrulation
Neural Tube Formation
Cell Migration
Directed Dilation
Chapter 9. Cell Differentiation
The Control of Gene Expression
Models of Cell Differentiation
The Reversibility of Patterns of Gene Activity
Chapter 10. Organogenesis
The Chick Limb
Insect Wings and Legs
The Nematode Vulva
Internal Organs: Heart, Blood Vessels, Lungs, Kidneys, and Teeth
Chapter 11. Development of the Nervous System
Specification of Cell Identity in the Nervous System
The Insect Compound Eye
Axonal Guidance
Neuronal Survival, Synapse Formation and Refinement
Chapter 12. Germ Cells and Sex
Determination of the Sexual Phenotype
The Development of Germ Cells
Fertilization
Chapter 13. Regeneration
Limb Regeneration
Regeneration in Hydra
Chapter 14. Growth and Post-Embryonic Development
Growth
Molting and Metamorphosis
Aging and Senescence
Chapter 15. Evolution and Development
Modification of Development in Evolution
Changes in the Timing of Developmental Processes During Evolution
Evolution of Development
Glossary
Index