Synopses & Reviews
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, Third Edition, is a primary textbook for a first course in pharmacology. It offers an integrated mechanism-based and systems-based approach, incorporating the cell biology, biochemistry, physiology, and pathophysiology of organ systems. The completely updated Third Edition features content reflecting current research findings, more than 400 full-color illustrations, Drug Summary Tables, and increased coverage of drug metabolism and the treatment of mycobacterial infections.
Synopsis
Highly regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th Edition, offers an integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps first- and second-year students grasp challenging concepts quickly and efficiently. Each chapter presents a clinical vignette illustrating a therapeutic problem within a physiologic or biochemical system; followed by a discussion of the biochemistry, physiology, and pathophysiology of the system; and concluding with a presentation of the pharmacology of the drugs and drug classes that activate or inhibit the system by interacting with specific molecular and cellular targets. Chapters are integrated into sections that focus on organ systems and therapeutic areas of highest importance. Clear, concise illustrations highlight key points, and drug summary tables offer quick access to essential information.
The Fourth Edition features:
- Comprehensive updates to all chapters, including recently approved drugs
- Nearly 40 popular and practical Drug Summary Tables with state-of-the-art information on clinical applications, serious and common adverse effects, contraindications, and therapeutic considerations
- A new chapter on drug transporters, and extensively revised information on drug-receptor interactions, pharmacodynamics, drug toxicity, and pharmacogenomics
- Key changes to Section 1: Fundamental Principles of Pharmacology, which now provides a comprehensive framework for material in all subsequent chapters
- Hundreds of meticulously updated and colorized illustrations, including many that are new or substantially modified to highlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms
Synopsis
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product.
Highly regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th Edition, offers an integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps first- and second-year students grasp challenging concepts quickly and efficiently. Each chapter presents a clinical vignette illustrating a therapeutic problem within a physiologic or biochemical system; followed by a discussion of the biochemistry, physiology, and pathophysiology of the system; and concluding with a presentation of the pharmacology of the drugs and drug classes that activate or inhibit the system by interacting with specific molecular and cellular targets. Chapters are integrated into sections that focus on organ systems and therapeutic areas of highest importance. Clear, concise illustrations highlight key points, and drug summary tables offer quick access to essential information.
The Fourth Edition features:
- Comprehensive updates to all chapters, including recently approved drugs
- Nearly 40 popular and practical Drug Summary Tables with state-of-the-art information on clinical applications, serious and common adverse effects, contraindications, and therapeutic considerations
- A new chapter on drug transporters, and extensively revised information on drug-receptor interactions, pharmacodynamics, drug toxicity, and pharmacogenomics
- Key changes to Section 1: Fundamental Principles of Pharmacology, which now provides a comprehensive framework for material in all subsequent chapters
- Hundreds of meticulously updated and colorized illustrations, including many that are new or substantially modified to highlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms
Synopsis
This new edition was recognized as a highly commended title by the British Medical Association at the
2017 BMA Medical Book Awards. Regarded by both students and instructors,
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th Edition, offers an integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps first- and second-year students grasp challenging concepts quickly and efficiently. Each chapter presents a clinical vignette illustrating a therapeutic problem within a physiologic or biochemical system; followed by a discussion of the biochemistry, physiology, and pathophysiology of the system; and concluding with a presentation of the pharmacology of the drugs and drug classes that activate or inhibit the system by interacting with specific molecular and cellular targets. Chapters are integrated into sections that focus on organ systems and therapeutic areas of highest importance. Clear, concise illustrations highlight key points, and drug summary tables offer quick access to essential information.
The Fourth Edition features:
- Comprehensive updates to all chapters, including recently approved drugs
- Nearly 40 popular and practical Drug Summary Tables with state-of-the-art information on clinical applications, serious and common adverse effects, contraindications, and therapeutic considerations
- A new chapter on drug transporters, and extensively revised information on drug-receptor interactions, pharmacodynamics, drug toxicity, and pharmacogenomics
- Key changes to Section 1: Fundamental Principles of Pharmacology, which now provides a comprehensive framework for material in all subsequent chapters
- Hundreds of meticulously updated and colorized illustrations, including many that are new or substantially modified to highlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms
Synopsis
Selected as a Doody's Core Title for 2021 This new edition was recognized as a highly commended title by the British Medical Association at the 2017 BMA Medical Book Awards . Regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th Edition, offers an integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps first- and second-year students grasp challenging concepts quickly and efficiently. Each chapter presents a clinical vignette illustrating a therapeutic problem within a physiologic or biochemical system; followed by a discussion of the biochemistry, physiology, and pathophysiology of the system; and concluding with a presentation of the pharmacology of the drugs and drug classes that activate or inhibit the system by interacting with specific molecular and cellular targets. Chapters are integrated into sections that focus on organ systems and therapeutic areas of highest importance. Clear, concise illustrations highlight key points, and drug summary tables offer quick access to essential information.
The Fourth Edition features:
- Comprehensive updates to all chapters, including recently approved drugs
- Nearly 40 popular and practical Drug Summary Tables with state-of-the-art information on clinical applications, serious and common adverse effects, contraindications, and therapeutic considerations
- A new chapter on drug transporters, and extensively revised information on drug-receptor interactions, pharmacodynamics, drug toxicity, and pharmacogenomics
- Key changes to Section 1: Fundamental Principles of Pharmacology, which now provides a comprehensive framework for material in all subsequent chapters
- Hundreds of meticulously updated and colorized illustrations, including many that are new or substantially modified to highlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms
Table of Contents
Section 1. Fundamental Principles of PharmacologyChapter 1. Drug-Receptor InteractionsChapter 2. PharmacodynamicsChapter 3. PharmacokineticsChapter 4. Drug MetabolismChapter 5. Drug ToxicityChapter 6and#160; Pharmacogenomicsand#160;Section 2. Principles of NeuropharmacologySection 2a. Fundamental Principles of NeuropharmacologyChapter 7. Principles of Cellular Excitability and Electrochemical TransmissionChapter 8. Principles of Nervous System Physiology and PharmacologySection 2b. Principles of Autonomic and Peripheral Nervous System PharmacologyChapter 9. Cholinergic PharmacologyChapter 10. Adrenergic PharmacologyChapter 11. Local Anesthetic PharmacologySection 2c. Principles of Central Nervous System PharmacologyChapter 12. Pharmacology of GABAergic and Glutamatergic NeurotransmissionChapter 13. Pharmacology of Dopaminergic NeurotransmissionChapter 14. Pharmacology of Serotonergic and Central Adrenergic NeurotransmissionChapter 15. Pharmacology of Abnormal Electrical Neurotransmission in the Central Nervous SystemChapter 16. General Anesthetic PharmacologyChapter 17. Pharmacology of AnalgesiaChapter 18. Pharmacology of Chemical Dependence and Addictionand#160;Section 3. Principles of Cardiovascular PharmacologyChapter 19. Pharmacology of Cholesterol and Lipoprotein MetabolismChapter 20. Pharmacology of Volume RegulationChapter 21. Pharmacology of Vascular ToneChapter 22. Pharmacology of Hemostasis and ThrombosisChapter 23. Pharmacology of Cardiac RhythmChapter 24. Pharmacology of Cardiac ContractilityChapter 25. Integrative Cardiovascular Pharmacology: Hypertension, Ischemic Heart Disease, and Heart Failureand#160;Section 4. Principles of Endocrine PharmacologyChapter 26. Pharmacology of the Hypothalamus and Pituitary GlandChapter 27. Pharmacology of the Thyroid GlandChapter 28. Pharmacology of the Adrenal CortexChapter 29. Pharmacology of ReproductionChapter 30. Pharmacology of the Endocrine PancreasChapter 31. Pharmacology of Bone Mineral Homeostasisand#160;Section 5. Principles of ChemotherapyChapter 32. Principles of Antimicrobial and Antineoplastic PharmacologyChapter 33. Pharmacology of Bacterial Infections: DNA Replication, Transcription, and TranslationChapter 34. Pharmacology of Bacterial and Mycobacterial Infections: Cell Wall SynthesisChapter 35. Pharmacology of Fungal InfectionsChapter 36. Pharmacology of Parasitic InfectionsChapter 37. Pharmacology of Viral InfectionsChapter 38. Pharmacology of Cancer: Genome Synthesis, Stability, and MaintenanceChapter 39. Pharmacology of Cancer: Signal TransductionChapter 40. Principles of Combination Chemotherapyand#160;Section 6. Principles of Inflammation and Immune PharmacologyChapter 41. Principles of Inflammation and the Immune SystemChapter 42. Pharmacology of EicosanoidsChapter 43. Histamine PharmacologyChapter 44. Pharmacology of Hematopoiesis and ImmunomodulationChapter 45. Pharmacology of ImmunosuppressionChapter 46. Integrative Inflammation Pharmacology: Peptic Ulcer DiseaseChapter 47. Integrative Inflammation Pharmacology: AsthmaChapter 48. Integrative Inflammation Pharmacology: Goutand#160;Section 7. Fundamentals of Drug Development and RegulationChapter 49. Drug Discovery and Preclinical DevelopmentChapter 50. Clinical Drug Evaluation and Regulatory ApprovalChapter 51. Systematic Detection of Adverse Events in Marketed Drugsand#160;Section 8. Poisoning by Drugs and Environmental Toxinsand#160;Chapter 52. Poisoning by Drugs and Environmental Toxinsand#160;Section 9. Frontiers in PharmacologyChapter 53. Protein-Based TherapiesChapter 54. Drug Delivery Modalities