Synopses & Reviews
The skin, the body's largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other physical and chemical agents.
Synopsis
This book presents recent research establishing the skin as an important peripheral neuroendocrine organ, tightly linked to central axes of stress, and research results on the response of epidermal cells to ultraviolet radiation, biological factors, and more.
Synopsis
Described as the body's largest organ, the skin is strategically located at the interface with the external environment where it has evolved to detect, integrate and respond to a diverse range of stressors including solar radiation. A flurry of recent findings has established the skin as an important peripheral (neuro)endocrine organ that is tightly networked to central stress axes. This capability is contributing to the maintenance of skin homeostasis. Specifically,
Table of Contents
Introduction.- Biogenic amines in the skin.- Melatoninergic system in the skin.- Cutaneous cholinergic system.- Corticotropin signaling system in the skin.- Steroidogenesis in the skin.- Equivalent of hypothalamo-pituitary adrenal axis in the skin.- Cutaneous secosteroidal system.- Equivalent of hypthalamic-pituitary-thyroid axis.- Cutaneous opioid system.- Cutaneous endocannabinoid system.- Perspectives.- References.- Subject index.