Synopses & Reviews
Sets forth an important group of environmentally friendly organic reactionsWith contributions from leading international experts in organic synthesis, this book presents all the most important methodologies for stereoselective organocatalysis, fully examining both the activation mode as well as the type of bond formed. Clear explanations guide researchers through all the most important methods used to form key chemical bonds, including carbon-carbon (CC), carbon-nitrogen (CN), and carbon-halogen (CX) bonds. Moreover, readers will discover how the use of non-metallic catalysts facilitates a broad range of important reactions that are environmentally friendly and fully meet the standards of green chemistry.
Stereoselective Organocatalysis begins with an historical overview and a review of activation modes in asymmetric organocatalysis. The next group of chapters is organized by bond type, making it easy to find bonds according to their applications. The first of these chapters takes a detailed look at the many routes to CC bond formation. Next, the book covers:
- Organocatalytic CN bond formation
- CO bond formation
- CX bond formation
- CS, CSe, and CB bond formation
- Enantioselective organocatalytic reductions
- Cascade reactions forming both CC bonds and Cheteroatom bonds
The final chapter is devoted to the use of organocatalysis for the synthesis of natural products. All the chapters in the book are extensively referenced, serving as a gateway to the growing body of original research reports and reviews in the field.
Based on the most recent findings and practices in organic synthesis, Stereoselective Organocatalysis equips synthetic chemists with a group of organocatalytic reactions that will help them design green reactions and overcome many challenges in organic synthesis.
Synopsis
This book covers the most important methodologies reported for stereoselective organocatalysis, based not only on the activation mode but also the type of bond formed. Starting with an introduction laying out the different activation modes, the chapters move on to describe the most important methodologies for the formation of key chemical bonds, including carbon-carbon (C-C), carbon-nitrogen (C-N), and carbon-halogen (C-X) bonds. It features an organization and approach useful for both students and practicing chemists in industry.
About the Author
RAMON RIOS TORRES, PhD, is Reader in Organic Chemistry at the University of Southampton. With more than ninety peer-reviewed articles and several book chapters to his credit, Dr. Rios Torres devotes his research to the development of new asymmetric methods based on organocatalysis and organometallic chemistry as well as the application of these methods in total synthesis. Dr. Rios Torres is also the editor of The Pauson-Khand Reaction: Scope, Variations and Applications (Wiley).
Table of Contents
Preface
List of Contributors
Foreword
1 Introduction: A historical point of view
Ramon Rios and Xavier Companyo
2 Activation Modes in Asymmetric Organocatalysis
Albert Moyano
3 C-C bond formation
3.1 By aldol reaction
Dorota Gryko and Dominika Walaszek
3.2 Examples of Metal-Free Direct Catalytic Asymmetric Mannich-Type Reactions using Aminocatalysis
Armando Cordova
3.3 By Michael reaction
Yong Zhang and Wei Wang
3.4 By Diels Alder and Other Pericyclic Reactions
Johan Franzén
3.5 N-Heterocyclic carbene-catalyzed C-C bond formation
Xiang-Yu Chen, Song Ye
3.6 α-Alkylation of carbonyl compounds
Marek Remeš and Jan Veselý
3.7 Other Reactions
Yi-Xia JIA and Tiexin Zhang
3.8 Cascade Reactions forming C-C bonds
Ramon Rios, Jorge Esteban and Xavier Companyó
4. Organocatalytic C-N bond formation
Aitor Landa, Rosa López, Antonia Mielgo, MikelOiarbide and Claudio Palomo
5. C-O bond formation
José Alemán, Mariola Tortosa
6. Carbon-halogen bond formation
Stacey E. Brenner-Moyer
7. C-other atom bond formation (S, Se, B)
Giorgio Della Sala, and Alessandra Lattanzi
8. Enantioselectiveorganocatalytic reductions
Maurizio Benaglia, Martina Bonsignore and Andrea Genoni
9. Cascade reactions forming both C–C bond and C–heteroatom bond
Damien Bonne, Thierry Constantieux, Yoann Coquerel and Jean Rodriguez
10. Organocatalysis in the Synthesis of Natural Products
Yongcheng Ying and Xuefeng Jiang