Synopses & Reviews
This compendium of research material on the role of oxidative stress in animal disease and morbidity examines both the general and the specific. Sourced from scientists, veterinarians, and members of the medical community from around the world, it includes chapters on our wider understanding of the corrosive function of free radicals in cell biology as well as focusing on the interplay between oxidative stress and metabolism in a variety of animal species including dogs, ruminants and birds. Since biogerontologist Denham Harman first posited that free radicals arising from the metabolic activity of oxygen play a central role in aging and disease, a mass of evidence has accumulated linking oxidative stress and biological degradation. We now understand that living in an aerobic environment inevitably leads to the production of free radicals that go on to attack biological membranes and lipoproteins via oxidation in a process called lipid peroxidation. Reacting with carbon-based molecules such as polyunsaturated fatty acids, these free radicals cause oxidative stress and tissue damage. The purpose of Studies on Veterinary Medicine is to inform clinicians, students and others of the plethora of consequences that free radical damage (ROS) has on various cells, tissues, and organs, as well as in different species of animals. The chapters also analyze the effects of oxidative stress on aging and various morbidities such as diabetes, cognitive dysfunction and heart disease. Contributors variously present their interpretation of the role played by oxidative damage in disease and assess the benefits of antioxidant therapies.
Synopsis
With a wealth of research material from around the world on the links between oxidative stress and animal morbidity, this volume covers our broader understanding of the subject as well as focusing on specific diseases and animal species such as dogs and birds.
Synopsis
Preface
Lester Mandelker
Peter Vajdovich
- Oxidative Stress, Free Radicals and Cellular Damage,
Lester Mandelker DVM
- Use of free radicals and antioxidants in inflammatory processes of animals
Peter Vajdovich DVM, PHD
- Oxidative Stress and Calcium Metabolism, Patricia Schenck DVM, PHD
- TRPM2 Cation Channels and Oxidative Stress-Induced Neuronal Cell Death
Mustafa Nazıroğlu1, PHD
- Oxidative stress in diabetes mellitus
Stefano Comazzi, DVM, PHD
- Oxidative Stress in the Spinal Cord of Dogs and Cats
Wendy Baltzer, DVM, PhD
- Oxidative Stress, Cognitive Dysfunction and Brain Aging
Elizabeth Head, Ph.D., * and Steven C. Zicker DVM, PhD
- The role of oxidative stress in ocular disease
Gustavo L. Zapata PHD
- Oxidative Stress in Heart Failure
Gordon Moe, MD, MSc
- Nutrient Selection in the Management of Canine Atopic Dermatitis
John Kuck DVM
- Avian antioxidants and oxidative stress: highlights from studies of food, physiology, and feathers
Kevin McGraw DVM
- Free Radicals and Antioxidants in Avian Diseases
Mikl s M zes, PhD and Kriszti n Balogh, PhD
- Oxidative Stress In Ruminants
Pietro Celi (DVM, PhD)
- Antioxidant Effects of Supplements
Lester Mandelker DVM and Peter Vajdovich DVM, PHD
Table of Contents
Preface
Lester Mandelker
Peter Vajdovich
- Oxidative Stress,