Angiogenesis, the development of new blood vessels from an existing vascular bed, is an essential feature in many pathological conditions, including cancer, atherosclerosis, rheumatoid arthritis, and diabetic neuropathy. Inadequate regulation of angiogenesis can often lead to chronic pressure ulcers, duodenal ulcers, and myocardial infarction. In The New Angiotherapy, an international team of experts critically review the recent progress in both basic and applied research on angiogenesis. Their cutting-edge discussion ranges from the stimulation and repression of angiogenesis to the discovery of novel angiotherapeutic targets and their use in the clinic. Details of fundamental concepts in angiogenesis physiology and pathophysiology are provided, and the potential of angiotherapy in the management of angiogenic disease is evaluated, highlighting some of the angiogenic and antiangiogenic agents both in development and in clinical trials. The future prospects of receptor antagonists, enzyme inhibitors, and vascular targeted approaches, especially gene therapy in the development of angiotherapy, are also covered. Authoritative and cutting-edge, The New Angiotherapy illuminates our understanding of the central role of human angiogenesis, as well as the novel therapeutic approaches now made possible by our ability to control vascular development.
From the Foreword by Judah Folkman, "In this very timely and informative book, Tai Ping Fan and Elise Kohn have assembled chapters authored by many of the leading scientists in the field of angiogenesis research. The molecular underpinnings of the angiogenic process in reproduction, development, repair and in disease, are clearly developed. Broad coverage is given to preclinical and clinical applications of angiogenesis inhibitors, and the book is a valuable source of references to the many aspects of the angiogenic process. . .The importance of quantifying effectiveness of antiangiogenic therapy is just one of many new directions in angiogenesis research both basic and clinical, which are highlighted by the authors. Future directions are also emphasized in the chapters on gene therapy, therapeutic angiogenesis for ischemic disease of the heart and limbs, and in new thinking about preventive antiangiogenic therapy." -Judah Folkman, July 2001 "This is an excellent collection of reviews in the field of angiogenesis therapy. This is an important area because growth factors are now in the clinical trials in the cardiovascular arena in an attempt to grow new vessels for ischemic disease. At the same time, antiangiogenesis is being evaluated to prevent tumor growth and neovascularization in the diabetic retina. Each chapter is well referenced and the index is very helpful in locating specific points in the book. This is an important addition to the medical literature. "-Doody's Health Sciences Book Review Journal, 96 score, 4 stars! "Fan and Kohn have assembled a group of international experts who have written up-to-date and detailed chapters on all aspects of the processes. The term 'therapeutic angiogenesis' encompasses the use of angiogenesis stimulation to overcome certain disease states. The material is quite detailed and aimed at investigators, but the book as a whole is an excellent reference for anyone interested in the field." - Oncology
I. Concepts
Vasculogenesis and Angiogenesis
Robert Auerbach and Wanda Auerbach
Angiogenesis-Regulating Cytokines
Michael S. Pepper, Stefano J. Mandriota, and Roberto Montesano
The Angiopoietins
Pamela F. Jones
Regulation of Vascular Morphogenesis by Extracellular Matrix Proteins
Amy D. Bradshaw and E. Helene Sage
II. Angiogenesis in Health and Disease
Integrin Receptors and the Regulation of Angiogenesis
Dorothy Rodriguez and Peter C. Brooks
Vasoactive Peptides in Angiogenesis
David Andrew Walsh and Tai-Ping D. Fan
Angiogenesis in Wound Healing and Surgery
Wayne A. Morrison, Geraldine M. Mitchell, Jane E. Barker, Tamara Konopka, and Alastair G. Stewart
Angiogenesis and Vascular Endothelial Growth Factor (VEGF) in Reproduction
D. Stephen Charnock-Jones, Yulong He, and Stephen K. Smith
Rheumatoid Arthritis: A Target for Anti-Angiogenic Therapy?
Ewa M. Paleolog and Jadwiga M. Miotla
Diagnostic and Prognostic Significance of Tumor Angiogenesis
Stephen B. Fox and Adrian L. Harris
III. Stimulation of Angiogenesis [Therapeutic Angiogenesis]
Hyaluronan Oligosaccharides Promote Wound Repair: Its Size-Dependent Regulation of Angiogenesis
David C. West and Tai-Ping D. Fan
Role of Thymic Peptides in Wound Healing
Hynda K. Kleinman, Derrick S. Grant, and Katherine M. Malinda
Angiogenesis and Growth Factors in Ulcer Healing
Sandor Szabo, Yuen Shing, M. Judah Folkman, Aron Vincze, Zoltan Gombos, Xiaoming Deng, Tetayana Khomenko, and Masashi Yoshida
Angiogenesis in Skeletal and Cardiac Muscle: Role of Mechanical Factors
Margaret D. Brown and Olga Hudlická
Therapeutic Angiogenesis for the Treatment of Cardiovascular Disease
Jeffrey M. Isner and Takayuki Asahara
Therapeutic Angiogenesis for the Heart
Johannes Waltenberger and Vinzenz Hombach
Contact-Guided Angiogenesis and Tissue Engineering
Robert A. Brown, Giorgio Terenghi, and Clive D. McFarland
IV. Anti-Angiogenesis
Inhibitors of Matrix Metalloproteinases
Peter D. Brown and William G. Stetler-Stevenson
Control of Angiogenesis by Microbial Products
Tsutomu Oikawa
Interaction of Angiogenic Growth Factors with Endothelial Cell Heparan Sulfate Proteoglycans: Implication for the Development of Angiostatic Compounds
Marco Rusnati, Giovanni Tulipano, and Marco Presta
2-Methoxyestradiol: A Novel Endogenous Chemotherapeutic and Anti-Angiogenic Agent
Victor S. Pribluda, Theresa M. LaVallee, and Shawn J. Green
V. Novel Targets
Receptor Tyrosine Kinases in Angiogenesis
Laura K. Shawver, Kenneth E. Lipson, T. Annie T. Fong, Gerald McMahon, and Laurie M. Strawn
Targeting Gene Therapy to the Tumor Vasculature
Kelvin K. W. Lau and Roy Bicknell
Antibody Targeting of Tumor Vasculature
J. Wilson, David C. West and Philip E. Thorpe
Endothelial Monocyte-Activating Polypeptide II: A Novel Injury Signal?
Cliff Murray and Maarten Tas
CD105 Antibody for Targeting of Tumor Vascular Endothelial Cells
Ben K. Seon and Shant Kumar
VI. Angiotherapy in the Clinic
Design of Pharmacological and Diagnostic Strategies for Angiogenesis-Dependent Diseases
Lucia Morbidelli and Marina Ziche
Design of Clinical Trials for Anti-Angiogenics
Elise C. Kohn
Angiogeneis Therapies: Concepts, Clinical Trials, and Considerations for New Drug Development
William W. Li, Vincent W. Li, and Dimitris Tsakayannis
Angiostatin and Endostatin: Recent Advances in Their Biology, Pharmacokinetics, and Potential Clinical Applications
Jesus V. Soriano and B. Kim Lee Sim