Synopses & Reviews
Synopsis
Research over the past decade has demonstrated that TGx methods of various types can be used to discriminate modes of mutagenesis as a function of dose. TGx can quickly inform safety evaluation regarding potential mechanisms of conventional outcomes and can provide essential dose-response information. This can then be used to ascertain the sequence of key events in a putative mode of action as may apply in quantitative cancer risk assessment. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data integration and health risk assessment. Furthermore, it is essential to consider how novel test systems and newer methods and approaches may be used in future to gain a better understanding of mechanisms.
Toxicogenomics in Predictive Carcinogenicity describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. It illustrates these methods using case studies that have yielded significant new information on compounds and classes of compounds that have proven difficult to evaluate using conventional methods alone. This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology.
This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology.
Synopsis
Toxicogenomics in Predictive Carcinogenicity describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. It illustrates these methods using case studies that have yielded significant new information on compounds and classes of compounds that have proven difficult to evaluate using conventional methods alone. This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology.The information is needed because it has not previously been available. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data integration and health risk assessment. Furthermore, it is essential to consider how novel test systems and newer methods and approaches may be used in future to gain a better understanding of mechanisms. The proposed publication will provide details of chemical case studies not available in previous volumes and will demonstrate how various data is assembled and integrated to arrive at an informed assessment of chemical safety and human health risk. It will be the most current volume which comprehensively covers the subject. This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology.
Societies:
American Association for Cancer Research AACR (http: //www.aacr.org/)
Environmental Mutagenesis and Genomics Society (http: //www.emgs/org)
International Association of Environmental Mutagen Societies (http: //www.iaems/org)
International Union of Toxicology (http: //www.iutox.org/)
Society of Toxicology (http: //www.toxicology.org/)
Journals for reviews:
Cancer Research
Mutation Research
Toxicology Research
Toxicology and Applied Pharmacology
Regulatory Toxicology and Pharmacology
Toxicology
Toxicology Letters
Critical Reviews in Toxicology
Archives of Toxicology
Pharmacology & Toxicology
Fundamental and Applied Toxicology
Toxicologic Pathology
Clinical Toxicology
Human and Experimental Toxicology
International Journal of Toxicology
Toxicology and Industrial Health
Drug and Chemical Toxicology
Drug safety
Journal of Toxicology
Toxicological Sciences
Websites:
American Association for Cancer Research AACR (http: //www.aacr.org/)
Environmental Mutagenesis and Genomics Society (http: //www.emgs/org)
International Association of Environmental Mutagen Societies (http: //www.iaems/org)
International Union of Toxicology (http: //www.iutox.org/)
Society of Toxicology (http: //www.toxicology.org/)
Cross-promote with the textbook Fundamental Toxicology