Synopses & Reviews
The increasing incidence of diabetes worldwide has prompted a rapid growth in the pace of scientific discovery and clinical understanding of this enigmatic disease. In Type 1 Diabetes: Etiology and Treatment, well-recognized physicians and researchers review the latest thinking about the causes of this condition and the best approaches to treating both its acute and chronic complications. The treatment options discussed range from life-threatening diabetic ketoacidosis to contemporary insulin regimens, from open- and closed-loop insulin delivery devices to modern glucose-sensing mechanisms, as well as such daily life issues as nutrition and education. Also discussed are the management of children under the age of five, the special problems of preadolescents and adolescents, diabetic surgery, and pregnancy, along with the treatment and prevention of the long-term vascular complications that produce coronary artery disease, the loss of limbs, end-stage renal disease, and blindness. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets. Authoritative and up-to-date, Type 1 Diabetes: Etiology and Treatment provides all those caring for diabetic patients with a concise, accessible survey of today's best thinking about the causes, treatment, and management of this complex disease.
Review
"The first section provides a sound discussion of our understanding of the etiology of the disease, providing the reader with an excellent working knowledge to assess possible future prevention strategies. The clinical chapters are well organized, authored by known experts, and provide excellent summaries of cutting edge management. The final chapters devoted to islet transplantation and the relevant scientific issues are timely and enlightening...This entry in the Contemporary Endocrinology series represents a uniquely accessible overview of the current scientific and clinical frontiers relevant to type 1 diabetes mellitus. By providing an understanding of where immunological knowledge will likely lead and what current therapy should entail, this book provides an opportunity for both clinical and research specialists to better understand each other's fields." -Doody's Health Sciences Book Review Journal "A highly recommended book that is hard to put down. It was easy to read, detailed, and extremely useful in a practical sense for clinicians." - E-Streams "The complex interactions of genetics, autoimmunity, and insulin secretion are covered thoroughly and would gainfully challenge most experts in the field." -Annals of Internal Medicine
Table of Contents
I. Etiology
Epidemiology of Type 1 Diabetes
Janice S. Dorman, Ronald E. LaPorte, and Thomas J. Songer
Genetics of Type 1 Diabetes
Massimo Pietropaolo and Massimo Trucco
Prediction and Prevention of Type 1 Diabetes
Aristides K. Maniatis and George S. Eisenbarth
Molecular Biology of b-Cell Destruction by Autoimmune Processes
Åke Lernmark and Choon Hee Chung
Type 1 Diabetes in Autoimmune Syndromes
Tiinamaija Tuomi and Jaakko Perheentupa
The Metabolic Basis of Insulin Secretion
Nicolai M. Doliba and Franz M. Matschinsky
Prevention and Correction of Hypoglycemia: Relevance to Type 1 Diabetes
Philip E. Cryer
Nonautoimmune Forms of Diabetes: Neonatal Diabetes, DIDMOAD-Wolfram Syndrome, and Related Syndromes
Timothy G. Barrett
II. Treatment of Type 1 Diabetes
Diabetic Ketoacidosis
Ram K. Menon and Mark A. Sperling
Insulin Regimens for Type 1 Diabetes
Baiju R. Shah and Bernard Zinman
Relationship Between Metabolic Control and Complications in Diabetes: Therapeutic Implications of the Diabetes Control and Complications Trial
Saul Genuth
Open- and Closed-Loop Insulin Delivery Systems and Glucose Sensors
John C. Pickup
Living with Diabetes: Educating the Patient and Family with Type 1 Diabetes
Jean Betschart Roemer and Linda Siminerio
Nutritional Management in Type 1 Diabetes
Christine A. Beebe
III. Special Management Issues in Type 1 Diabetes
Special Problems and Management of the Child Less than 5 Years of Age
Nadia Tubiana-Rufi and Paul Czernichow
The Preadolescent Child with Type 1 Diabetes
William V. Tamborlane, Elizabeth A. Boland, and Margaret Grey
The Adolescent with Type 1 Diabetes
George A. Werther, Fergus J. Cameron, and John M. Court
Hypoglycemia in Type 1 Diabetes
Stephanie A. Amiel and Krystyna Matyka
Pregnancy and Type 1 Diabetes
Erica M. Sommermann, Erin K. Van Meter, and Lois Jovanovic
Surgery for the Patient with Type 1 Diabetes
Adrian Vella and Robert A. Rizza
IV. Long-Term Complications of Type 1 Diabetes
Biochemistry and Molecular Biology of Diabetic Complications
Kenya Sakamoto and Michael Brownlee
The Eye: Diabetic Retinopathy/Ophthalmopathy
David Kent and Peter A. Campochiaro
The Kidney: Diabetic Nephropathy
Abhay Vats and Frederick DeRubertis
Diabetic Peripheral and Autonomic Neuropathy
Eva L. Feldman, Martin J. Stevens, and James W. Russell
The Diabetic Foot
David L. Steed
Atherosclerosis in Type 1 Diabetes
Wael Emad Eid, Siripoom McKay, Finnbogi Karlsson, and Alan J. Garber
Cutaneous Complications of Type 1 Diabetes
Jean L. Bolognia and Irwin M. Braverman
Infection and Diabetes
Nirmal Joshi
Pancreas Transplantation
R. Paul Robertson
Islet Transplantation
Thierry Berney, Norma Sue Kenyon, Rodolfo Alejandro, Luca Inverardi, Daniel H. Mintz, and Camillo Ricordi
b-Cell Replacement Therapy for Type 1 Diabetes
Shimon Efrat
Islet Growth Factors
Rupangi C. Vasavada, Adolfo Garcia-Ocaña, Karen K. Takane, Ana Cebrian, Juan Carlos Lopez-Talavera, and Andrew F. Stewart
Index